[
1. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005; 307:1915-1920. doi: https://dx.doi.org/10.1126/science.110481610.1126/science.110481615790844
]Search in Google Scholar
[
2. Nash AK, Auchtung TA, Wong MC, et al. The gut mycobiome of the Human Microbiome Project healthy cohort. Microbiome 2017; 5:153. doi: https://dx.doi.org/10.1186/s40168-017-0373-410.1186/s40168-017-0373-4570218629178920
]Search in Google Scholar
[
3. Scarpellini E, Ianiro G, Attili F, Bassanelli C, De Santis A, Gasbarrini A. The human gut micro-biota and virome: Potential therapeutic implications. Dig Liver Dis 2015; 47(12):1007-1012. doi: https://dx.doi.org/10.1016/j.dld.2015.07.00810.1016/j.dld.2015.07.008718561726257129
]Search in Google Scholar
[
4. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J 2017; 474(11): 1823–1836. doi: https://dx.doi.org/10.1042/BCJ2016051010.1042/BCJ20160510543352928512250
]Search in Google Scholar
[
5. Guidelines for the evaluation of probiotics in food report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. London Ontario, Canada April 30 and May 1, 2002. https://www.who.int/food-safety/fs_management/en/probiotic_guidelines.pdf Accessed: April 20, 2021.
]Search in Google Scholar
[
6. Gibson G. et al. Dietary prebiotics: current status and new definition. Food Sci Tech Bull Functional Foods 2010; 7:1-19.10.1616/1476-2137.15880
]Search in Google Scholar
[
7. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature 2012; 489(7415):220-230. doi: https://dx.doi.org/10.1038/nature1155010.1038/nature11550357737222972295
]Search in Google Scholar
[
8. El Aidy S, Derrien M, Aardema R, et al. Transient inflammatory-like state and microbial dysbiosis are pivotal in establishment of mucosal homeostasis during colonisation of germ-free mice. Benef Microbes 2014; 5:67-77. doi: https://dx.doi.org/10.3920/BM2013.001810.3920/BM2013.001824322881
]Search in Google Scholar
[
9. Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci 2019; 76(3):473-493. doi: https://dx.doi.org/10.1007/s00018-018-2943-410.1007/s00018-018-2943-430317530
]Search in Google Scholar
[
10. Savage DC. Microbial ecology of the gastrointestinal tract. Ann Rev Microbiol 1997; 31:107– 133. doi: https://dx.doi.org/10.1146/annurev.mi.31.100177.00054310.1146/annurev.mi.31.100177.000543334036
]Search in Google Scholar
[
11. Lagier JC, Khelaifia S, Alou M, et al. Culture of previously uncultured members of the human gut microbiota by culturomics. Nat Microbiol 2016; 1:16203. doi: https://dx.doi.org/10.1038/nmicrobiol.2016.20310.1038/nmicrobiol.2016.20327819657
]Search in Google Scholar
[
12. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005; 307:1915-1920. doi: https://dx.doi.org/10.1126/science.110481610.1126/science.110481615790844
]Search in Google Scholar
[
13. Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017; 9:1021. doi: https://dx.doi.org/10.3390/nu909102110.3390/nu9091021562278128914794
]Search in Google Scholar
[
14. Hess JM, Jonnalagadda SS, Slavin JL. Dairy Foods: Current evidence of their effects on bone, cardiometabolic, cognitive, and digestive health. Compr Rev Food Sci Food Safe 2016; 15:251-268. doi: https://dx.doi.org/10.1111/1541-4337.1218310.1111/1541-4337.1218333371600
]Search in Google Scholar
[
15. Bron PA, Kleerebezem M, Brummer RJ, et al. Can probiotics modulate human disease by impacting intestinal barrier function? Br J Nutr 2017; 117(1):93-107. doi: https://dx.doi.org/10.1017/S000711451600403710.1017/S0007114516004037529758528102115
]Search in Google Scholar
[
16. Souvik T, John D, Ankita G. A review on probiotic dairy products and digestive health. J Pharmacogn Phytochem 2019; 8(3):368-372.
]Search in Google Scholar
[
17. Cleusix V, Lacroix C, Vollenweider S, Duboux M, Le Blay G. Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria. BMC Microbiol 2007; 7:101. doi: https://dx.doi.org/10.1186/1471-2180-7-10110.1186/1471-2180-7-101222262917997816
]Search in Google Scholar
[
18. Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C, Gahan CG. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci USA 2007; 104(18):7617-7621. doi: https://dx.doi.org/10.1073/pnas.070044010410.1073/pnas.0700440104186347217456596
]Search in Google Scholar
[
19. Rescigno M, Di Sabatino A. Dendritic cells in intestinal homeostasis and disease. J Clin Invest 2009; 119(9):2441-2450. doi: https://dx.doi.org/10.1172/JCI3913410.1172/JCI39134273593119729841
]Search in Google Scholar
[
20. Corthésy B. Multi-faceted functions of secre-tory IgA at mucosal surfaces. Front Immunol 2013; 4:185. doi: https://dx.doi.org/10.3389/fimmu.2013.0018510.3389/fimmu.2013.00185370941223874333
]Search in Google Scholar
[
21. Everard A, Geurts L, Caesar R, et al. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun 2014; 5:5648. doi: https://dx.doi.org/10.1038/ncomms664810.1038/ncomms6648426870525476696
]Search in Google Scholar
[
22. Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 2006; 313:1126-1130. doi: https://dx.doi.org/10.1126/science.112711910.1126/science.1127119271666716931762
]Search in Google Scholar
[
23. Marlicz W, Yung DE, Skonieczna-Żydecka K, et al. From clinical uncertainties to precision medicine: the emerging role of the gut barrier and microbiome in small bowel functional diseases. Expert Rev Gastroenterol Hepatol 2017; 11(10):961-978. doi: https://dx.doi.org/10.1080/17474124.2017.134366410.1080/17474124.2017.134366428618973
]Search in Google Scholar
[
24. Bäckhed F, Fraser CM, Ringel Y, et al. Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe 2012; 12(5):611-622. doi: https://dx.doi.org/10.1016/j.chom.2012.10.01210.1016/j.chom.2012.10.01223159051
]Search in Google Scholar
[
25. Wang L, Alammar N, Singh R, et al. Gut microbial dysbiosis in the irritable bowel syndrome: A systematic review and meta-analysis of case-control sudies. J Acad Nutr Diet 2020; 120(4):565-586. doi: https://dx.doi.org/10.1016/j.jand.2019.05.01510.1016/j.jand.2019.05.01531473156
]Search in Google Scholar
[
26. Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, Andoh A. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin J Gastroenterol 2018; 11(1):1-10. doi: https://dx.doi.org/10.1007/s12328-017-0813-510.1007/s12328-017-0813-529285689
]Search in Google Scholar
[
27. Syer SD, Blackler RW, Martin R, et al. NSAID enteropathy and bacteria: a complicated relationship. J Gastroenterol 2015; 50(4):387-393. doi: https://dx.doi.org/10.1007/s00535-014-1032-110.1007/s00535-014-1032-125572030
]Search in Google Scholar
[
28. Layer P, Andresen V, Pehl C, et al. S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungsund Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)1 [Irritable bowel syndrome: German consensus guidelines on definition, pathophysiology and management]. Z Gastroenterol 2011; 49(2):237-293. [in German] doi: https://dx.doi.org/10.1055/s-0029-124597610.1055/s-0029-124597621287438
]Search in Google Scholar
[
29. Ford AC, Moayyedi P, Lacy BE, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol 2014; 109:S2-S26. doi: https://dx.doi.org/10.1038/ajg.2014.18710.1038/ajg.2014.18725091148
]Search in Google Scholar
[
30. Zhang Y, Li L, Guo C, et al. Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis. BMC Gastroenterol 2016; 16:62. https://dx.doi.org/10.1186/s12876-016-0470-z10.1186/s12876-016-0470-z490725827296254
]Search in Google Scholar
[
31. Korterink JJ, Ockeloen L, Benninga MA, Tabbers MM, Hilbink M, Deckers-Kocken JM. Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis. Acta Paediatr 2014; 103(4):365-372. doi: https://dx.doi.org/10.1111/apa.1251310.1111/apa.1251324236577
]Search in Google Scholar
[
32. Guo Q, Goldenberg JZ, Humphrey C, El Dib R, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 2019; 4(4):CD004827. doi: https://dx.doi.org/10.1002/14651858.CD004827.pub510.1002/14651858.CD004827.pub5649079631039287
]Search in Google Scholar
[
33. Szajewska H, Skórka A, Ruszczyński M, Gieruszczak-Białek D. Meta-analysis: Lactobacillus GG for treating acute gastroenteritis in children – updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013; 38(5):467-476. doi: https://dx.doi.org/10.1111/apt.1240310.1111/apt.1240323841880
]Search in Google Scholar
[
34. Shan LS, Hou P, Wang ZJ, et al. Prevention and treatment of diarrhoea with Saccharomyces boulardii in children with acute lower respiratory tract infections. Benef Microbes 2013; 4:329-334. doi: https://dx.doi.org/10.3920/BM2013.000810.3920/BM2013.000824311316
]Search in Google Scholar
[
35. Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010; 2010(11):CD003048. doi: https://dx.doi.org/10.1002/14651858.CD003048.pub310.1002/14651858.CD003048.pub3653269921069673
]Search in Google Scholar
[
36. McFarland LV. Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Med Infect Dis 2007; 5:97-105. doi: https://dx.doi.org/10.1016/j.tmaid.2005.10.00310.1016/j.tmaid.2005.10.00317298915
]Search in Google Scholar
[
37. Guerra PV, Lima LN, Souza TC, et al. Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World J Gastroenterol 2011; 17(34):3916-3921. doi: https://dx.doi.org/10.3748/wjg.v17.i34.391610.3748/wjg.v17.i34.3916319802122025880
]Search in Google Scholar
[
38. Ford AC, Quigley EM, Lacy BE, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol 2014; 109(10):1547-1562. doi: https://dx.doi.org/10.1038/ajg.2014.20210.1038/ajg.2014.20225070051
]Search in Google Scholar
[
39. Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA 2012; 307:1959-1969. doi: https://dx.doi.org/10.1001/jama.2012.350710.1001/jama.2012.350722570464
]Search in Google Scholar
[
40. Indrio F, Riezzo G, Raimondi F, et al. Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants. Eur J Clin Invest 2011; 41:417-422. doi: https://dx.doi.org/10.1111/j.1365-2362.2010.02425.x10.1111/j.1365-2362.2010.02425.x21114493
]Search in Google Scholar
[
41. Quigley EM, Quera R. Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics. Gastroenterology 2006; 130(2 Suppl. 1):S78-S90. doi: https://dx.doi.org/10.1053/j.gastro.2005.11.04610.1053/j.gastro.2005.11.04616473077
]Search in Google Scholar
[
42. Cheng J, Ouwehand AC. Gastroesophageal re-flux disease and probiotics: A systematic review. Nutrients 2020; 12(1):132. doi: https://dx.doi.org/10.3390/nu1201013210.3390/nu12010132701977831906573
]Search in Google Scholar
[
43. Sung JJ, Kuipers EJ, El-Serag HB. Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther 2009; 29:938-946. doi: https://dx.doi.org/10.1111/j.1365-2036.2009.03960.x10.1111/j.1365-2036.2009.03960.x19220208
]Search in Google Scholar
[
44. Hirayama F, Takagi S, Kusuhara H, Iwao E, Yokoyama Y, Ikeda Y. Induction of gastric ulcer and intestinal metaplasia in Mongolian gerbils infected with Helicobacter pylori. J Gastroenterol 1996; 31(5):755-757. doi: https://dx.doi.org/10.1007/BF0234763110.1007/BF023476318887049
]Search in Google Scholar
[
45. Wang GZ, Huang GP, Yin GL, Zhou G, Guo CJ, et al. Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. Cell Physiol Biochem 2007; 20(1-4):205-212. doi: https://dx.doi.org/10.1159/00010416710.1159/00010416717595529
]Search in Google Scholar
[
46. Elliott SN, Buret A, McKnight W, Miller MJ, Wallace JL. Bacteria rapidly colonize and modulate healing of gastric ulcers in rats. Am J Physiol Cell Physiol 1998; 275(3):G425-G432. doi: https://dx.doi.org/10.1152/ajpgi.1998.275.3.G42510.1152/ajpgi.1998.275.3.G4259724253
]Search in Google Scholar
[
47. Khoder G, Al-Menhali AA, Al-Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Exp Ther Med 2016; 12(1):3-17. doi: https://dx.doi.org/10.3892/etm.2016.329310.3892/etm.2016.3293490669927347010
]Search in Google Scholar
[
48. Clark PA, Cotton LN, Martin JH. Selection of bifidobacteria for use as dietary adjuncts in cultured dairy foods. II. Tolerance to simulated pH of human stomachs. Cult Dairy Prod J 1993; 28(4):11-14.
]Search in Google Scholar
[
49. Lankaputhra W, Shah NP. Survival of Lactobacillus acidophilus and Bifidobacterium spp. in the presence of acid and bile salts. Cult Dairy Prod J 1995; 30:2-7.
]Search in Google Scholar
[
50. Asaka M, Kato M, Kudo M, Meguro T, Kimura T, Miyazaki T, Inoue K. The role of Helicobacter pylori in peptic ulcer disease. Gastroenterol Jpn 1993; 28 (Suppl. 5):163-167. doi: https://dx.doi.org/10.1007/BF0298922810.1007/BF029892288359625
]Search in Google Scholar
[
51. Zheng X, Lyu L, Mei Z. Lactobacillus-containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis. Rev Esp Enferm Dig 2013; 105(8):445-453. doi: https://dx.doi.org/10.4321/s1130-0108201300080000210.4321/S1130-01082013000800002
]Search in Google Scholar
[
52. Lu C, Sang J, He H, Wan X, Lin Y, Li L et al. Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis. Sci Rep 2016; 6:23522. doi: https://dx.doi.org/10.1038/srep2352210.1038/srep23522480073326997149
]Search in Google Scholar
[
53. Sartor RB, Wu GD. Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology 2017; 152(2):327-339.e4. doi: https://dx.doi.org/10.1053/j.gastro.2016.10.01210.1053/j.gastro.2016.10.012551175627769810
]Search in Google Scholar
[
54. Khanna S, Raffals LE. The microbiome in Crohn’s disease: Role in pathogenesis and role of microbiome replacement therapies. Gastroenterol Clin North Am 2017; 46(3):481-492. doi: https://dx.doi.org/10.1016/j.gtc.2017.05.00410.1016/j.gtc.2017.05.00428838410
]Search in Google Scholar
[
55. Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 2014; 146(6):1489-1499. doi: https://dx.doi.org/10.1053/j.gastro.2014.02.00910.1053/j.gastro.2014.02.009403413224560869
]Search in Google Scholar
[
56. Colombel JF. Decade in review-IBD: IBD-genes, bacteria and new therapeutic strategies. Nat Rev Gastroenterol Hepatol 2014; 11(11):652-654. doi: https://dx.doi.org/10.1038/nrgastro.2014.17010.1038/nrgastro.2014.17025311475
]Search in Google Scholar
[
57. Dong J, Teng G, Wei T, Gao W, Wang H. Methodological quality assessment of meta-analyses and systematic reviews of probiotics in inflammatory bowel disease and pouchitis. PloS one 2016; 11(12):e0168785. doi: https://dx.doi.org/10.1371/journal.pone.016878510.1371/journal.pone.0168785517908728005973
]Search in Google Scholar
[
58. Limketkai BN, Akobeng AK, Gordon M, Adepoju AA. Probiotics for induction of remission in Crohn’s disease. Cochrane Database Syst Rev 2020; 7(7):CD006634. doi: https://dx.doi.org/10.1002/14651858.CD006634.pub310.1002/14651858.CD006634.pub3738933932678465
]Search in Google Scholar
[
59. Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn’s disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis 2014; 20(1):21-35. doi: https://dx.doi.org/10.1097/01.MIB.0000437495.30052.be10.1097/01.MIB.0000437495.30052.be24280877
]Search in Google Scholar
[
60. Naidoo K, Gordon M, Fagbemi AO, Thomas AG, Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2011; 12:CD007443. doi: https://dx.doi.org/10.1002/14651858.CD007443.pub210.1002/14651858.CD007443.pub222161412
]Search in Google Scholar
[
61. Surawicz CM, McFarland LV. Pseudomembranous colitis: causes and cures. Digestion 1999; 60(2):91-100. doi: https://dx.doi.org/10.1159/00000763310.1159/00000763310095149
]Search in Google Scholar
[
62. Dinleyici M, Vandenplas Y. Clostridium difficile colitis prevention and treatment. Adv Exp Med Biol 2019; 1125:139-146. doi: https://dx.doi.org/10.1007/5584_2018_32210.1007/5584_2018_32230689174
]Search in Google Scholar
[
63. Kassam Z, Lee CH, Yuan Y, Hunt RH. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol 2013; 108(4):500-508. doi: https://dx.doi.org/10.1038/ajg.2013.5910.1038/ajg.2013.5923511459
]Search in Google Scholar
[
64. Stallmach A, Steube A, Grunert P, Hartmann M, Biehl LM, Vehreschild M. Fecal microbiota transfer. Dtsch Arztebl Int 2020; 117(3):31-38. doi: https://dx.doi.org/10.3238/arztebl.2020.003110.3238/arztebl.2020.0031702657032031511
]Search in Google Scholar
[
65. Xu J, Ma R, Chen LF, Zhao LJ, Chen K, Zhang RB. Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. HBPD Int 2014; 13(4):354-360. doi: https://dx.doi.org/10.1016/s1499-3872(14)60280-010.1016/S1499-3872(14)60280-0
]Search in Google Scholar
[
66. Cao Q, Yu CB, Yang SG, Cao HC, Chen P, Deng M, Li LJ. Effect of probiotic treatment on cirrhotic patients with minimal hepatic encephalopathy: A meta-analysis. HBPD Int 2018: 17(1):9-16. doi: https://dx.doi.org/10.1016/j.hbpd.2018.01.00510.1016/j.hbpd.2018.01.005
]Search in Google Scholar
[
67. Aller R, De Luis DA, Izaola O, Conde R, Gonzalez Sagrado M, Primo D et al. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 2011; 15(9):1090-1095.
]Search in Google Scholar
[
68. Buss C, Valle-Tovo C, Miozzo S, Alves de Mattos A. Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients. Ann Hepatol 2014; 13(5):482-488.10.1016/S1665-2681(19)31246-3
]Search in Google Scholar
[
69. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr 2019; 59(11):1675-1683. doi: https://dx.doi.org/10.1080/10408398.2018.142597710.1080/10408398.2018.142597729425071
]Search in Google Scholar
