Quantitative Analysis of Humectants in Tobacco Products Using Gas Chromatography (GC) with Simultaneous Mass Spectrometry (MSD) and Flame Ionization Detection (FID)

1. Heck, J., C. Gaworski, N. Rajendran, and R. Morrissey: Toxicological Evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 Rats; Inhal. Toxicol. 14 (2002) 1135–1152.Search in Google Scholar

2. Hoffmann, D. and I. Hoffmann: The changing cigarette, 1950–1995; J. Toxicol. Environ. Health 50 (1997) 307–364.Search in Google Scholar

3. Browne, C.: The Design of Cigarettes. 3^rd ed.; Hoechst Celanese Corp: Charlotte, NC, 1990.Search in Google Scholar

4. Rodgman, A.: Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties II: Casing Materials and Humectants; Beitr. Tabakforsch. Int. 20 (2002) 279–299.Search in Google Scholar

5. Klus, H., G. Scherer, and L. Müller: Influence of Additives on Cigarette Related Health Risks; Beitr. Tabakforsch. Int. 25 (2012) 411–493.Search in Google Scholar

6. Friedman, R. and W. Raab: Determination of Tobacco Humectants by Gas Liquid Chromatography; Anal. Chem. 35 (1963) 67–69.Search in Google Scholar

7. Giles, J.: Collaborative Study on the Determination of Propylene Glycol, Glycerine, and Triethylene Glycol in Tobacco; J. Ass. Offic. Anal. Chem. 53 (1970) 655–658.Search in Google Scholar

8. Williams, J.: Collaborative Study of the Determination of Propylene Glycol, Glycerol, and Triethylene Glycol in Tobacco; J. Ass. Offic. Anal. Chem. 54 (1971) 560–564.Search in Google Scholar

9. CORESTA: Routine Analytical Chemistry Sub-Group Technical Report on 2007 Joint Experiment to Update Repeatability and Reproducibility Statistics for: CRM (Determination of 1,2-Propylene Glycol and Glycerol in Tobacco Products by GC); CRM 61 (Deter-mination of 1,2-Propylene Glycol and Glycerol in Tobacco Products by HPLC); Centre for Scientific Research Relative to Tobacco, 2010. 10.CORESTA Recommended Method No. 60: Determination of 1,2-Propylene Glycol and Glycerol in Tobacco and Tobacco Products by Gas Chro-matography; Cooperation Centre for Scientific Research Relative to Tobacco, 2011.Search in Google Scholar

11. Health Canada: Determination of Humectants in Whole Tobacco; Health Canada -Official Method T-304, 1999.Search in Google Scholar

12. Schubert, J., J. Hahn, G. Dettbarn, A. Seidel, A. Luch, and T. Schulz: Mainstream Smoke of the Waterpipe: Does this Environmental Matrix Reveal as Significant Source of Toxic Compounds?; Toxicol. Lett. 205 (2011) 279–284.Search in Google Scholar

13. CORESTA Recommended Method No. 61: Deter-mination of 1,2-Propylene Glycol, Glycerol and Sorbitol in Tobacco and Tobacco Products by High Performance Liquid Chromatography (HPLC); Cooperation Centre for Scientific Research Relative to Tobacco, 2011.Search in Google Scholar

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