Rivista e Edizione

AHEAD OF PRINT

Volume 69 (2022): Edizione 2 (August 2022)

Volume 69 (2022): Edizione s1 (July 2022)

Volume 69 (2022): Edizione 1 (January 2022)

Volume 68 (2021): Edizione 2 (December 2021)

Volume 68 (2021): Edizione 1 (January 2021)

Volume 67 (2020): Edizione 2 (May 2020)

Volume 67 (2020): Edizione 1 (January 2020)

Volume 66 (2019): Edizione 2 (November 2019)

Volume 66 (2019): Edizione 1 (June 2019)

Volume 65 (2018): Edizione 2 (November 2018)

Volume 65 (2018): Edizione 1 (June 2018)

Volume 64 (2017): Edizione 2 (November 2017)

Volume 64 (2017): Edizione 1 (September 2017)

Volume 63 (2016): Edizione s12 (December 2016)

Volume 63 (2016): Edizione 2 (December 2016)

Volume 63 (2016): Edizione 1 (September 2016)

Volume 62 (2015): Edizione s10 (September 2015)

Volume 62 (2015): Edizione s9 (June 2015)

Volume 62 (2015): Edizione 2 (December 2015)

Volume 62 (2015): Edizione 1 (June 2015)

Volume 61 (2014): Edizione 2 (December 2014)

Volume 61 (2014): Edizione 1 (August 2014)

Volume 60 (2013): Edizione Supplementum-VIII (March 2013)
Rare disease day in Slovakia, Europlan national conference

Volume 60 (2013): Edizione 2 (December 2013)

Volume 60 (2013): Edizione 1 (June 2013)

Volume 59 (2012): Edizione Supplement-VII (February 2012)
Conference abstracts, Rare disease day, conference 29.2.2012, First Slovak conference about rare diseases

Volume 59 (2012): Edizione Supplement-VI (January 2012)
Clinical Pharmacy in the Slovak Republic, dedicated to the associated professor Lívia Magulová, PhD.

Volume 59 (2012): Edizione 2 (November 2012)

Volume 59 (2012): Edizione 1 (June 2012)

Volume 58 (2011): Edizione 1 (January 2011)

Dettagli della rivista
Formato
Rivista
eISSN
2453-6725
Pubblicato per la prima volta
25 Nov 2011
Periodo di pubblicazione
2 volte all'anno
Lingue
Inglese

Cerca

Volume 69 (2022): Edizione 1 (January 2022)

Dettagli della rivista
Formato
Rivista
eISSN
2453-6725
Pubblicato per la prima volta
25 Nov 2011
Periodo di pubblicazione
2 volte all'anno
Lingue
Inglese

Cerca

7 Articoli
Accesso libero

The Evaluation of Cardiovascular Risk in Diabetic Patients

Pubblicato online: 04 Apr 2022
Pagine: 1 - 8

Astratto

Abstract AIM

The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender.

METHODS

The monitoring was designed as a retrospective analysis of data obtained from the documentation of the diabetic outpatients treated with the dipeptidyl peptidase-4 inhibitors (DPP4is) or sodium–glucose co-transporter-2 (SGLT2). Cardiovascular risk was assessed according to UKPDS risk engine.

RESULTS

The levels of HbA1c decreased throughout the whole study. Sixty per cent of patients achieved an HbA1c level <8% after 18 months. Both men and women had similar glycaemic compensation. Men had a significantly higher risk of fatal coronary heart disease (CHD) (p < 0.001), stroke (p < 0.01) and fatal stroke (p < 0.01) compared to women. We found the risk of fatal CHD to be 38-fold higher in men compared to women (p < 0.01).

CONCLUSION

Potential cardiovascular effects of antidiabetic treatment should be clearly defined with possible different effects according to gender. We found a much higher risk in men than women, even when their glycaemic compensation was comparable.

Parole chiave

  • diabetes
  • UKPDS
  • coronary heart disease
  • stroke
  • gender
Accesso libero

Shortages of medicines in a psychiatric hospital in Cyprus

Pubblicato online: 13 May 2022
Pagine: 9 - 15

Astratto

Abstract Background

The incidence of drug shortages has surged in recent years and it poses a major threat to public health worldwide. It can also downgrade the quality of care provided to patients. Data concerning shortages pertinent to mental health care are scarce, while treatment continuity is vital to avert disease recurrence and deterioration of patients’ mental health.

Objective

The scope of this study is to elucidate the attitudes and perceptions of mental health professionals regarding drug shortages in Cyprus in a tertiary health institute, through a specially designed questionnaire.

Results

The most frequently reported effects of psychiatric drug shortages were the impaired efficacy of the alternative therapeutic regimen, re-admission of patients, delays in care provision and increased frequency of adverse events. Concerning the loss of working hours in managing drug shortages, the majority responded that they dedicate 1 to 5 working hours to this per week. Informing the patient about alternative medication and the ongoing shortages were the first strategies to minimise the effects of shortages, as attested by 74% and 72% of responders, respectively. The proposed solutions for drug shortages included thorough investigation of the root causes, the elaboration of an e-based database, drawing up a national annual report and assuming legal responsibility of pharmaceutical companies. Drug shortages constitute an important burden in the field of mental health care in Cyprus. Given the serious impact of the problem and the externalities of mental health disorders, appropriate measures must be swiftly taken to ensure timely and effective administration of the appropriate therapeutic regimen.

Parole chiave

  • medicine shortages
  • Cyprus
  • mental health
Accesso libero

A Study of Phenolic Bioactive Compounds Of Daucus Carota Subsp. Sativus Fruits of Yaskrava, Nantska Kharkivska and Olenka Species and Of Dauci Carotae Subsp. Sativi Fructuum Extractum Siccum

Pubblicato online: 24 Jun 2022
Pagine: 16 - 26

Astratto

Abstract

The objective of the work was to study the qualitative composition and determine the quantitative content of phenolic compounds of Daucus carota subsp. sativus fruits of Yaskrava, Nantska Kharkivska and Olenka species and of Dauci carotae subsp. sativi fructuum extractum siccum. Phenolic compounds were studied by UPLC-ESI-MS/MS method. High content of phenol-origin bioactive substances was fixed in Daucus carota subsp. sativus fruits of Nantska Kharkivska variety (363.19 μg/g). Dominating compounds were chlorogenic acid, cynaroside, rutin and hyperoside. Daucus carota subsp. sativus fruits of all study species under question were found to possess permanent qualitative composition of phenolic compounds, whereas their quantitative content in experimental samples differed slightly. The results of analysis confirm promising development of novel antioxidant and cardioprotective drugs on the basis of Dauci carotae subsp. sativi fructuum extractum siccum.

Parole chiave

  • Daucus carota subsp. Sativus
  • UPLC-ESI-MS/MS
  • phenolic compounds
  • antioxidant activity
Accesso libero

The influence of mineral nutrition and humic acids on the intensity of photosynthesis, as well as the yield and quality of seeds, roots, and aboveground phytomass of milk thistle Silybum marianum (L.) Gaertn. in marginal growing conditions

Pubblicato online: 24 Jun 2022
Pagine: 27 - 36

Astratto

Abstract

Milk thistle Silybum marianum (L.) Gaertn. is one of the most researched medicinal plants, but at the same time it belongs to crops with wide industry potential whose growth requirements for marginal agroecological conditions or the response to agronomic interventions has not yet been sufficiently studied. The aim of the present research was to verify the effect of mineral nutrition (NPK 200 kg/ha) and humic acids applied to the soil (HUMAC Agro 250 kg/ha) on the main biometric parameters and the intensity of photosynthesis of milk thistle grown under less favourable climatic conditions of the semi-cold and humid foothills in Central Europe. The highest seed yield was achieved with the NPK variant in terms of dry matter 0.534 t/ha, in the HUMAC Agro variant 0.254 t/ha and with the untreated control 0.087 t/ha. The soil before the trial establishment was characterised by low nutrient content. The use of mineral fertiliser on NPK treatment eliminated the influence of low PK nutrients content of the soil, influencing the crop growth and yield/quality, while no doses of NPK were used on the HUMAC Agro variant and the untreated control. For both of the two sequences created (temperature and light), the highest photosynthesis rate was measured on untreated control (20.115 and 12.386 mmol/m2/s1), markedly lower on HUMAC Agro (16.386 and 9.653 mmol/m2/s1) – and the lowest on the NPK (10.933 and 7.813 mmol/m2/s1, respectively), in inverse proportion to the crop yield. Therefore, the size of the leaf area of the crop was decisive for the increased crop yield. The polynomial trend line of the photosynthesis rate according to the temperature sequence shows the photosynthesis rate and the torrential decrease by temperature increasing on untreated control compared with both treated variants. Both of these threats, mineral nutrition and use of humic preparations to soil, although they reduce the photosynthesis rate, have a wide range of complex effects that provide an opportunity to optimise the growth and yield of milk thistle. Ideally, the mineral nutrition and humic preparations should be used in combination with the crop of milk thistle for medicinal and energy purposes.

Parole chiave

  • milk thistle
  • phytomass
  • yield quality
  • photosynthesis rate
  • humic acids
  • marginal conditions
Accesso libero

Short cognitive screening in elderlies as a part of advanced pharmaceutical care in Slovak community pharmacies - The pilot study KOGNIMET-SK

Pubblicato online: 24 Jun 2022
Pagine: 37 - 42

Astratto

Abstract

The aim of this study is to evaluate the implementation of a simple, easy-to-use cognitive screening test in the pharmaceutical care of elderly patients (aged 60 years and over) in community pharmacies and to test whether cognitive decline is associated with metabolic syndrome (MetS).

Current research has reported the increasing prevalence of MetS with age and indicated a link between cardiovascular risk factors and impairment of cognitive functions. We hypothesized that the short cognitive test realised in pharmaceutical care in community pharmacies could help identify risk groups of patients with potential cognitive decline. Because of the increasing pressure on primary care, collaboration between community pharmacists and general practitioners is essential, especially in preventive programmes and regarding chronically ill patients.

The study included 222 elderly patients aged 60 years and over reached between February 2018 and February 2019 in 16 community pharmacies in Slovakia. Criteria for the classification of MetS were used, following the International Diabetes Federation Worldwide Definition of MetS (2005) for European populations. Cognitive performance was evaluated using the Slovak version of the Montreal Cognitive Assessment. The scale range of the MoCA test is 0–30 points, and the cut-off for cognitive impairment is ≤ 24 points.

Our outcomes show that the presence of metabolic syndrome only slightly contributes to the impairment of cognitive functions of patients receiving routine pharmaceutical care in community pharmacies. Cognitive assessment might be an important tool for identifying risk groups of patients that would benefit from a specific approach within the framework of pharmaceutical care.

Parole chiave

  • metabolic syndrome
  • cognitive impairment
  • elderly
  • pharmaceutical service
  • community pharmacy
Accesso libero

Influence of Organic Solvents and β-cyclodextrins on Capillary Zone Electrophoresis Separation of Five Biogenic Amines and Two B Vitamins

Pubblicato online: 06 Aug 2022
Pagine: 43 - 53

Astratto

Abstract

The effects of organic modifiers—alcohols (methanol, isopropanol), acetonitrile, and tetrahydrofuran—and β-cyclodextrins in capillary zone electrophoresis were investigated using a test mixture containing five biogenic amines important from the human health point of view—serotonin, dopamine, adrenaline, noradrenaline, and tyramine—and two B vitamins—thiamine and pyridoxine. The simultaneous addition of tetrahydrofuran and isopropanol was found to improve the resolution of determined analytes and enable effective separation of analytes with very similar electromigration characteristics migrating as one peak (dopamine and serotonin). The developed and optimised separation method based on capillary zone electrophoresis and ultraviolet detection was capable to achieve detection limits at the concentration level in the range of 0.15 to 1.25 μg/mL−1. The developed method was also characterised by other favourable validation parameters, such as linearity (r2 > 0.99), accuracy (82.9–117.8% for the intraday measurements, and 87.6–119.2% for the interday measurements), and precision (intraday relative standard deviation in the range of 0.4–15.5%, interday relative standard deviation in the range of 0.9–18.3%). The method was finally applied to investigate the stability of the analytes in model water matrix samples under various storage conditions.

Parole chiave

  • biogenic amines
  • thiamine
  • pyridoxine
  • capillary zone electrophoresis
  • cyclodextrins
  • organic solvents
Accesso libero

The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress

Pubblicato online: 13 Jul 2022
Pagine: 54 - 60

Astratto

Abstract

This study is devoted to the experimental study of the immunocorrecting action of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the model of “social” stress formed as a result of sensory contact and inter-confrontation. Functional activity of the immune system of laboratory animals was assessed on the basis of standard immunopharmacological tests: delayed-type hypersensitivity reaction (DTH), direct agglutination test (DAT), latex test for studying the phagocytic activity of peripheral blood neutrophils, and evaluation of changes in the leukocyte formula. As a result of the experiment, it was found that, under the influence of “social” stress, changes in the immune response are multidirectional, which confirms the theory of “immune disbalance” under the action of stressors. As a result of studying the influence of Semax and Selank on the model of “social” stress, it was found that the drug proved to be an effective corrector, restoring the cellular and humoral immunogenesis reactions, the phagocytic activity of neutrophils, which indicates the presence of immunomodulating properties, and emphasizes the need for further studies in this scientific direction. This study expands the scientific research base in the field of immunoreaction under stress-induced conditions with the aim of further developing a pharmacological strategy for correcting the revealed disorders by means of substances of a neuropeptide structure.

Parole chiave

  • social stress
  • sensory contact
  • Semax
  • Selank
  • delayed-type hypersensitivity (DTH) reactions
  • direct agglutination test (DAT)
  • phagocytic index (PhI)
  • phagocytic number (PhN)
7 Articoli
Accesso libero

The Evaluation of Cardiovascular Risk in Diabetic Patients

Pubblicato online: 04 Apr 2022
Pagine: 1 - 8

Astratto

Abstract AIM

The aim of the study was to evaluate cardiovascular risk in patients with diabetes mellitus type 2 according to gender.

METHODS

The monitoring was designed as a retrospective analysis of data obtained from the documentation of the diabetic outpatients treated with the dipeptidyl peptidase-4 inhibitors (DPP4is) or sodium–glucose co-transporter-2 (SGLT2). Cardiovascular risk was assessed according to UKPDS risk engine.

RESULTS

The levels of HbA1c decreased throughout the whole study. Sixty per cent of patients achieved an HbA1c level <8% after 18 months. Both men and women had similar glycaemic compensation. Men had a significantly higher risk of fatal coronary heart disease (CHD) (p < 0.001), stroke (p < 0.01) and fatal stroke (p < 0.01) compared to women. We found the risk of fatal CHD to be 38-fold higher in men compared to women (p < 0.01).

CONCLUSION

Potential cardiovascular effects of antidiabetic treatment should be clearly defined with possible different effects according to gender. We found a much higher risk in men than women, even when their glycaemic compensation was comparable.

Parole chiave

  • diabetes
  • UKPDS
  • coronary heart disease
  • stroke
  • gender
Accesso libero

Shortages of medicines in a psychiatric hospital in Cyprus

Pubblicato online: 13 May 2022
Pagine: 9 - 15

Astratto

Abstract Background

The incidence of drug shortages has surged in recent years and it poses a major threat to public health worldwide. It can also downgrade the quality of care provided to patients. Data concerning shortages pertinent to mental health care are scarce, while treatment continuity is vital to avert disease recurrence and deterioration of patients’ mental health.

Objective

The scope of this study is to elucidate the attitudes and perceptions of mental health professionals regarding drug shortages in Cyprus in a tertiary health institute, through a specially designed questionnaire.

Results

The most frequently reported effects of psychiatric drug shortages were the impaired efficacy of the alternative therapeutic regimen, re-admission of patients, delays in care provision and increased frequency of adverse events. Concerning the loss of working hours in managing drug shortages, the majority responded that they dedicate 1 to 5 working hours to this per week. Informing the patient about alternative medication and the ongoing shortages were the first strategies to minimise the effects of shortages, as attested by 74% and 72% of responders, respectively. The proposed solutions for drug shortages included thorough investigation of the root causes, the elaboration of an e-based database, drawing up a national annual report and assuming legal responsibility of pharmaceutical companies. Drug shortages constitute an important burden in the field of mental health care in Cyprus. Given the serious impact of the problem and the externalities of mental health disorders, appropriate measures must be swiftly taken to ensure timely and effective administration of the appropriate therapeutic regimen.

Parole chiave

  • medicine shortages
  • Cyprus
  • mental health
Accesso libero

A Study of Phenolic Bioactive Compounds Of Daucus Carota Subsp. Sativus Fruits of Yaskrava, Nantska Kharkivska and Olenka Species and Of Dauci Carotae Subsp. Sativi Fructuum Extractum Siccum

Pubblicato online: 24 Jun 2022
Pagine: 16 - 26

Astratto

Abstract

The objective of the work was to study the qualitative composition and determine the quantitative content of phenolic compounds of Daucus carota subsp. sativus fruits of Yaskrava, Nantska Kharkivska and Olenka species and of Dauci carotae subsp. sativi fructuum extractum siccum. Phenolic compounds were studied by UPLC-ESI-MS/MS method. High content of phenol-origin bioactive substances was fixed in Daucus carota subsp. sativus fruits of Nantska Kharkivska variety (363.19 μg/g). Dominating compounds were chlorogenic acid, cynaroside, rutin and hyperoside. Daucus carota subsp. sativus fruits of all study species under question were found to possess permanent qualitative composition of phenolic compounds, whereas their quantitative content in experimental samples differed slightly. The results of analysis confirm promising development of novel antioxidant and cardioprotective drugs on the basis of Dauci carotae subsp. sativi fructuum extractum siccum.

Parole chiave

  • Daucus carota subsp. Sativus
  • UPLC-ESI-MS/MS
  • phenolic compounds
  • antioxidant activity
Accesso libero

The influence of mineral nutrition and humic acids on the intensity of photosynthesis, as well as the yield and quality of seeds, roots, and aboveground phytomass of milk thistle Silybum marianum (L.) Gaertn. in marginal growing conditions

Pubblicato online: 24 Jun 2022
Pagine: 27 - 36

Astratto

Abstract

Milk thistle Silybum marianum (L.) Gaertn. is one of the most researched medicinal plants, but at the same time it belongs to crops with wide industry potential whose growth requirements for marginal agroecological conditions or the response to agronomic interventions has not yet been sufficiently studied. The aim of the present research was to verify the effect of mineral nutrition (NPK 200 kg/ha) and humic acids applied to the soil (HUMAC Agro 250 kg/ha) on the main biometric parameters and the intensity of photosynthesis of milk thistle grown under less favourable climatic conditions of the semi-cold and humid foothills in Central Europe. The highest seed yield was achieved with the NPK variant in terms of dry matter 0.534 t/ha, in the HUMAC Agro variant 0.254 t/ha and with the untreated control 0.087 t/ha. The soil before the trial establishment was characterised by low nutrient content. The use of mineral fertiliser on NPK treatment eliminated the influence of low PK nutrients content of the soil, influencing the crop growth and yield/quality, while no doses of NPK were used on the HUMAC Agro variant and the untreated control. For both of the two sequences created (temperature and light), the highest photosynthesis rate was measured on untreated control (20.115 and 12.386 mmol/m2/s1), markedly lower on HUMAC Agro (16.386 and 9.653 mmol/m2/s1) – and the lowest on the NPK (10.933 and 7.813 mmol/m2/s1, respectively), in inverse proportion to the crop yield. Therefore, the size of the leaf area of the crop was decisive for the increased crop yield. The polynomial trend line of the photosynthesis rate according to the temperature sequence shows the photosynthesis rate and the torrential decrease by temperature increasing on untreated control compared with both treated variants. Both of these threats, mineral nutrition and use of humic preparations to soil, although they reduce the photosynthesis rate, have a wide range of complex effects that provide an opportunity to optimise the growth and yield of milk thistle. Ideally, the mineral nutrition and humic preparations should be used in combination with the crop of milk thistle for medicinal and energy purposes.

Parole chiave

  • milk thistle
  • phytomass
  • yield quality
  • photosynthesis rate
  • humic acids
  • marginal conditions
Accesso libero

Short cognitive screening in elderlies as a part of advanced pharmaceutical care in Slovak community pharmacies - The pilot study KOGNIMET-SK

Pubblicato online: 24 Jun 2022
Pagine: 37 - 42

Astratto

Abstract

The aim of this study is to evaluate the implementation of a simple, easy-to-use cognitive screening test in the pharmaceutical care of elderly patients (aged 60 years and over) in community pharmacies and to test whether cognitive decline is associated with metabolic syndrome (MetS).

Current research has reported the increasing prevalence of MetS with age and indicated a link between cardiovascular risk factors and impairment of cognitive functions. We hypothesized that the short cognitive test realised in pharmaceutical care in community pharmacies could help identify risk groups of patients with potential cognitive decline. Because of the increasing pressure on primary care, collaboration between community pharmacists and general practitioners is essential, especially in preventive programmes and regarding chronically ill patients.

The study included 222 elderly patients aged 60 years and over reached between February 2018 and February 2019 in 16 community pharmacies in Slovakia. Criteria for the classification of MetS were used, following the International Diabetes Federation Worldwide Definition of MetS (2005) for European populations. Cognitive performance was evaluated using the Slovak version of the Montreal Cognitive Assessment. The scale range of the MoCA test is 0–30 points, and the cut-off for cognitive impairment is ≤ 24 points.

Our outcomes show that the presence of metabolic syndrome only slightly contributes to the impairment of cognitive functions of patients receiving routine pharmaceutical care in community pharmacies. Cognitive assessment might be an important tool for identifying risk groups of patients that would benefit from a specific approach within the framework of pharmaceutical care.

Parole chiave

  • metabolic syndrome
  • cognitive impairment
  • elderly
  • pharmaceutical service
  • community pharmacy
Accesso libero

Influence of Organic Solvents and β-cyclodextrins on Capillary Zone Electrophoresis Separation of Five Biogenic Amines and Two B Vitamins

Pubblicato online: 06 Aug 2022
Pagine: 43 - 53

Astratto

Abstract

The effects of organic modifiers—alcohols (methanol, isopropanol), acetonitrile, and tetrahydrofuran—and β-cyclodextrins in capillary zone electrophoresis were investigated using a test mixture containing five biogenic amines important from the human health point of view—serotonin, dopamine, adrenaline, noradrenaline, and tyramine—and two B vitamins—thiamine and pyridoxine. The simultaneous addition of tetrahydrofuran and isopropanol was found to improve the resolution of determined analytes and enable effective separation of analytes with very similar electromigration characteristics migrating as one peak (dopamine and serotonin). The developed and optimised separation method based on capillary zone electrophoresis and ultraviolet detection was capable to achieve detection limits at the concentration level in the range of 0.15 to 1.25 μg/mL−1. The developed method was also characterised by other favourable validation parameters, such as linearity (r2 > 0.99), accuracy (82.9–117.8% for the intraday measurements, and 87.6–119.2% for the interday measurements), and precision (intraday relative standard deviation in the range of 0.4–15.5%, interday relative standard deviation in the range of 0.9–18.3%). The method was finally applied to investigate the stability of the analytes in model water matrix samples under various storage conditions.

Parole chiave

  • biogenic amines
  • thiamine
  • pyridoxine
  • capillary zone electrophoresis
  • cyclodextrins
  • organic solvents
Accesso libero

The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress

Pubblicato online: 13 Jul 2022
Pagine: 54 - 60

Astratto

Abstract

This study is devoted to the experimental study of the immunocorrecting action of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the model of “social” stress formed as a result of sensory contact and inter-confrontation. Functional activity of the immune system of laboratory animals was assessed on the basis of standard immunopharmacological tests: delayed-type hypersensitivity reaction (DTH), direct agglutination test (DAT), latex test for studying the phagocytic activity of peripheral blood neutrophils, and evaluation of changes in the leukocyte formula. As a result of the experiment, it was found that, under the influence of “social” stress, changes in the immune response are multidirectional, which confirms the theory of “immune disbalance” under the action of stressors. As a result of studying the influence of Semax and Selank on the model of “social” stress, it was found that the drug proved to be an effective corrector, restoring the cellular and humoral immunogenesis reactions, the phagocytic activity of neutrophils, which indicates the presence of immunomodulating properties, and emphasizes the need for further studies in this scientific direction. This study expands the scientific research base in the field of immunoreaction under stress-induced conditions with the aim of further developing a pharmacological strategy for correcting the revealed disorders by means of substances of a neuropeptide structure.

Parole chiave

  • social stress
  • sensory contact
  • Semax
  • Selank
  • delayed-type hypersensitivity (DTH) reactions
  • direct agglutination test (DAT)
  • phagocytic index (PhI)
  • phagocytic number (PhN)

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