Edizioni

Rivista e Edizione

Volume 132 (2022): Edizione 1 (January 2022)

Volume 131 (2021): Edizione 1 (January 2021)

Volume 130 (2020): Edizione 1 (January 2020)

Volume 129 (2019): Edizione 4 (December 2019)

Volume 129 (2019): Edizione 3 (September 2019)

Volume 129 (2019): Edizione 2 (June 2019)

Volume 129 (2019): Edizione 1 (March 2019)

Volume 128 (2018): Edizione 4 (December 2018)

Volume 128 (2018): Edizione 3 (September 2018)

Volume 128 (2018): Edizione 2 (June 2018)

Volume 128 (2018): Edizione 1 (January 2018)

Volume 127 (2017): Edizione 4 (December 2017)

Volume 127 (2017): Edizione 3 (September 2017)

Volume 127 (2017): Edizione 2 (June 2017)

Volume 127 (2017): Edizione 1 (March 2017)

Volume 126 (2016): Edizione 4 (December 2016)

Volume 126 (2016): Edizione 3 (September 2016)

Volume 126 (2016): Edizione 2 (June 2016)

Volume 126 (2016): Edizione 1 (March 2016)

Volume 125 (2015): Edizione 4 (December 2015)

Volume 125 (2015): Edizione 3 (September 2015)

Volume 125 (2015): Edizione 2 (June 2015)

Volume 125 (2015): Edizione 1 (March 2015)

Volume 124 (2014): Edizione 4 (December 2014)

Volume 124 (2014): Edizione 3 (September 2014)

Volume 124 (2014): Edizione 2 (June 2014)

Volume 124 (2014): Edizione 1 (March 2014)

Dettagli della rivista
Formato
Rivista
eISSN
2083-4829
Pubblicato per la prima volta
23 Apr 2014
Periodo di pubblicazione
1 volta all'anno
Lingue
Inglese

Cerca

Volume 132 (2022): Edizione 1 (January 2022)

Dettagli della rivista
Formato
Rivista
eISSN
2083-4829
Pubblicato per la prima volta
23 Apr 2014
Periodo di pubblicazione
1 volta all'anno
Lingue
Inglese

Cerca

6 Articoli
Accesso libero

SARS-CoV-2 antibody screening in healthcare workers: lessons learned from the first months of COVID-19 outbreak in Europe. Significance of serology testing for effective pandemic management and reduction of the occupational risk

Pubblicato online: 20 Jul 2022
Pagine: 1 - 10

Astratto

Abstract

Introduction. Detected in 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a coronavirus disease 2019 (COVID-19), has changed almost all aspects of human lives. It has had an enormous impact on societies, economies and politics across the world. Nevertheless, first and foremost, it has led to a global health crisis on an unprecedented scale. Since the pandemic’s beginning, one of the greatest global challenges has been to stop the spread of infection among healthcare workers (HCWs). As a front-line fighters, they are at higher risk of contracting SARS-CoV-2 than other professions.

Aim. The study aimed to determine the role of serological testing among HCWs by analyzing screening results for the presence of SARS-CoV-2 antibodies in this group in 12 European countries during the first wave of the pandemic.

Material and methods. Pubmed, MEDLINE, Web of Science, Google Scholar, and WHO COVID-19 databases were searched for studies on screening among HCWs using immunoassays or chemiluminescence assays for preventive purposes and determining the percentage of HCWs with acquired immunity to SARS-CoV-2. The number of 30 papers were selected. Immunoglobulin G (IgG) percentage was analyzed, and determination of immunoglobulin A (IgA) and immunoglobulin M (IgM) antibodies and their diagnostic usefulness.

Results. The screening results of HCWs were juxtaposed with epidemic situation of that time and public health measures in given country.

Conclusion. Introduction of routine serological testing of HCWs could be a valuable strategy to monitor the occupational risk in this group and effectiveness of local epidemic management strategies.

Parole chiave

  • SARS-CoV-2
  • COVID-19
  • serologic test
  • health personel
  • seroprevalence
  • IgG antibody
Accesso libero

Gut microbiome in non-alcoholic fatty liver disease

Pubblicato online: 20 Jul 2022
Pagine: 11 - 15

Astratto

Abstract

The human gut microbiome is composed of communities of bacteria, viruses and fungi. Bacteria live in each part of digestive tract, increasing their density and changing composition in distal parts. The composition of gut microbiome mainly depends on method of childbirth, age, gender, diet, stress, infections, alcohol intake, diurnal variation, smoking, drugs (antibiotics), physical activity. Dysbiosis is defined as an imbalance or maladaptation in the gut microbial community. This imbalance favors many pathological states and it could be due to some diseases. Non-alcoholic fatty liver disease (NAFLD) has become increasingly common in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome. In year 2020, a more comprehensive new definition of NAFLD was proposed – fatty liver disease associated with metabolic dysfunction (MAFLD). NAFLD/MALFD will become the major form of chronic liver disease in adults and children and could become the leading indication for liver transplantation within a decade. An increased level of Bacteroidetes and decreased level of Firmicutes is observed in fatty liver disease. This imbalance favors the collection of energy and insulin resistance. The prevention and treatment of dysbiosis in NAFLD/MAFLD is essential.

The purpose of this review is an understanding related to the dysbiosis and non-alcoholic fatty liver disease in order to help physicians of different specialties in their clinical practice because of growing in population patients with metabolic syndrome and liver steatosis.

Parole chiave

  • gut microbiome
  • dysbiosis
  • non-alcoholic fatty liver disease
  • probiotics
  • eubiotics
  • prokinetics
Accesso libero

Socio-professional adaptation of a nurse in a new workplace

Pubblicato online: 17 Oct 2022
Pagine: 16 - 20

Astratto

Abstract

Introduction. The period of socio-professional adaptation is a time when the new employee often feels insecure and is accompanied by emotional tension. Already in the initial period of work, an employee develops a specific attitude towards the environment, which, at a later stage, influences professional development or motivation.

Aim. The aim of the study is to assess the course of the process of social and professional adaptation among nurses who, after graduation, started their first job in hospital departments in the Lubuskie Voivodeship, as well as to characterize the adaptation process and factors influencing its effective course.

Material and methods. The material for the research was collected by means of a proprietary questionnaire. The number of 118 people participated in the study.

Results. There was a statistical dependence between the socio-professional adaptation process and the existence of procedures related to it. Then a relationship was noted between the procedures for the adaptation process and the presentation of the adaptation plan to the new employee. Statistically significant differences were demonstrated by analyzing the feeling of being ready to work independently depending on the duration of the adaptation period in a new workplace.

Conclusion. The adaptation process is often ineffective and important elements, such as access to adaptation procedures, adaptation plan, employee final evaluation, are often overlooked. These elements have a statistically significant impact on the overall assessment of the adaptation process. The adaptation period is often too short, which translates into the lack of readiness to work for new employees.

Parole chiave

  • socio-professional adaptation
  • nurses
  • adaptation in hospitals
Accesso libero

Nicotine addiction – a health problem in adolescents in a neurobiological context

Pubblicato online: 17 Oct 2022
Pagine: 21 - 24

Astratto

Abstract

Smoking is one of the leading causes of death which can be prevented in the developed countries. Smoking begins mainly in adolescence. Smoking in early adolescence is known to be associated with an increased risk of later addiction. Also the growing popularity of e-cigarettes, which attract young people with a variety of flavors, and are still little associated with harmful effects on health, unlike regular cigarettes. Exposure to nicotine in young people can affect learning, memory and attention, and lead to increased impulsivity, mood disorders and drug dependence. Nicotine and its derivatives are harmful to the human body, causing a significant increase in blood pressure, deterioration of blood supply to the vessels and acceleration of atherosclerotic processes, it has a detrimental effect on the gastric mucosa, causing gastric disorders. In addition, smoking is associated with the risk of many cancers: oral cavity, larynx, esophagus, lung, pancreas, kidney, liver and bladder. Nicotine addiction causes many health, social and financial consequences for the individual and the community as a whole. Multiple nicotine addiction risk SNPs were found in the CHRNA5/A3/B4 gene cluster, with the best reported results for the risk allele derived from the non-synonymous SNP, rs16969968, in CHRNA5. Therefore, in the problem of addiction, including nicotine addiction, it seems important to know the neurobiological factors, including genetic ones, involved in these processes. This could lead to the development of new pharmacological and behavioral treatment strategies in the future.

Parole chiave

  • nicotine addiction
  • health problem
  • gene
  • adolescents
Accesso libero

The role of the OPRM1 gene polymorphism and its methylation in people in dependence on substances and with different intensity of pain

Pubblicato online: 17 Oct 2022
Pagine: 25 - 30

Astratto

Abstract

Opioid receptors belong to the group of Gi and Go coupled receptors, inhibiting the activity of the neuron. Opioid receptors regulate reward and aversion. The opioid system contributes to self and species survival by promoting reward elicited by natural stimuli (such as food, sex and social interaction), regulating mood states and facilitating efficient coping with pain and stress. It is suggested that OPRM1 polymorphism is associated with alcohol consumption especially increased in the case of G alleles subjects than A-alleles homozygotes. In several studies, OPRM1 methylation was suspected to be predictive factor of opioid dependence in pain treatment.

The relationship of postoperative or preoperative pain with methylation of some CpG sites in the OPRM1 promoter has also been demonstrated. It is known that OPRM1 SNPs provide changes in the structure of the MOR receptor, so by confirming the pharmacogenetic effects of OPRM1 polymorphisms and using these results to guide therapeutic decisions, patients can be prescribed treatment options with the best efficacy and greatest tolerance. Pharmacogenomics of OPRM1 can improve pain management by predicting individual response to pain medications before treatment and facilitate the development of new and more effective pain medications for post-operative pain.

Parole chiave

  • polymorphism
  • opioid receptor
  • alcohol dependence
  • analgesia
  • methylation
Accesso libero

The disease X: waiting for the next pandemic

Pubblicato online: 20 Nov 2022
Pagine: 31 - 33

Astratto

Abstract

In 2008 the WHO published a report on infectious diseases against which there is no effective treatment or vaccines and therefore – diseases able to cause pandemic. In addition, so called disease X was mentioned – potentially deadly, with no herd immunity against it, holding pandemic potential, unknown in medicine yet. In 2019 such disease X was COVID-19. There is a plausibility, that next pandemic will be induced by zoonotic RNA virus (alike SARS-CoV-2) infecting people in place of intensified human-animal contacts (like high-density animal farming) without proper legal regulations in terms of animal husbandry and high population density. Also in the past major pandemics in XX and XXI centuries were result of zoonotic transmissions (HIV/AIDS, SARS, MERS, Spanish flu, avian flu, swine flu, Ebola). The key in risk recognising is governments and international healthcare agencies’ reaction – proper countermeasures to control pandemic range should be taken. Animal trade should be legally regulated and deforestation limited. There is also an urgent need for funding R&D studies on diseases listed by the WHO.

Parole chiave

  • zoonosis
  • emergency infectious disease
  • pandemic
  • pathogen
6 Articoli
Accesso libero

SARS-CoV-2 antibody screening in healthcare workers: lessons learned from the first months of COVID-19 outbreak in Europe. Significance of serology testing for effective pandemic management and reduction of the occupational risk

Pubblicato online: 20 Jul 2022
Pagine: 1 - 10

Astratto

Abstract

Introduction. Detected in 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a coronavirus disease 2019 (COVID-19), has changed almost all aspects of human lives. It has had an enormous impact on societies, economies and politics across the world. Nevertheless, first and foremost, it has led to a global health crisis on an unprecedented scale. Since the pandemic’s beginning, one of the greatest global challenges has been to stop the spread of infection among healthcare workers (HCWs). As a front-line fighters, they are at higher risk of contracting SARS-CoV-2 than other professions.

Aim. The study aimed to determine the role of serological testing among HCWs by analyzing screening results for the presence of SARS-CoV-2 antibodies in this group in 12 European countries during the first wave of the pandemic.

Material and methods. Pubmed, MEDLINE, Web of Science, Google Scholar, and WHO COVID-19 databases were searched for studies on screening among HCWs using immunoassays or chemiluminescence assays for preventive purposes and determining the percentage of HCWs with acquired immunity to SARS-CoV-2. The number of 30 papers were selected. Immunoglobulin G (IgG) percentage was analyzed, and determination of immunoglobulin A (IgA) and immunoglobulin M (IgM) antibodies and their diagnostic usefulness.

Results. The screening results of HCWs were juxtaposed with epidemic situation of that time and public health measures in given country.

Conclusion. Introduction of routine serological testing of HCWs could be a valuable strategy to monitor the occupational risk in this group and effectiveness of local epidemic management strategies.

Parole chiave

  • SARS-CoV-2
  • COVID-19
  • serologic test
  • health personel
  • seroprevalence
  • IgG antibody
Accesso libero

Gut microbiome in non-alcoholic fatty liver disease

Pubblicato online: 20 Jul 2022
Pagine: 11 - 15

Astratto

Abstract

The human gut microbiome is composed of communities of bacteria, viruses and fungi. Bacteria live in each part of digestive tract, increasing their density and changing composition in distal parts. The composition of gut microbiome mainly depends on method of childbirth, age, gender, diet, stress, infections, alcohol intake, diurnal variation, smoking, drugs (antibiotics), physical activity. Dysbiosis is defined as an imbalance or maladaptation in the gut microbial community. This imbalance favors many pathological states and it could be due to some diseases. Non-alcoholic fatty liver disease (NAFLD) has become increasingly common in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome. In year 2020, a more comprehensive new definition of NAFLD was proposed – fatty liver disease associated with metabolic dysfunction (MAFLD). NAFLD/MALFD will become the major form of chronic liver disease in adults and children and could become the leading indication for liver transplantation within a decade. An increased level of Bacteroidetes and decreased level of Firmicutes is observed in fatty liver disease. This imbalance favors the collection of energy and insulin resistance. The prevention and treatment of dysbiosis in NAFLD/MAFLD is essential.

The purpose of this review is an understanding related to the dysbiosis and non-alcoholic fatty liver disease in order to help physicians of different specialties in their clinical practice because of growing in population patients with metabolic syndrome and liver steatosis.

Parole chiave

  • gut microbiome
  • dysbiosis
  • non-alcoholic fatty liver disease
  • probiotics
  • eubiotics
  • prokinetics
Accesso libero

Socio-professional adaptation of a nurse in a new workplace

Pubblicato online: 17 Oct 2022
Pagine: 16 - 20

Astratto

Abstract

Introduction. The period of socio-professional adaptation is a time when the new employee often feels insecure and is accompanied by emotional tension. Already in the initial period of work, an employee develops a specific attitude towards the environment, which, at a later stage, influences professional development or motivation.

Aim. The aim of the study is to assess the course of the process of social and professional adaptation among nurses who, after graduation, started their first job in hospital departments in the Lubuskie Voivodeship, as well as to characterize the adaptation process and factors influencing its effective course.

Material and methods. The material for the research was collected by means of a proprietary questionnaire. The number of 118 people participated in the study.

Results. There was a statistical dependence between the socio-professional adaptation process and the existence of procedures related to it. Then a relationship was noted between the procedures for the adaptation process and the presentation of the adaptation plan to the new employee. Statistically significant differences were demonstrated by analyzing the feeling of being ready to work independently depending on the duration of the adaptation period in a new workplace.

Conclusion. The adaptation process is often ineffective and important elements, such as access to adaptation procedures, adaptation plan, employee final evaluation, are often overlooked. These elements have a statistically significant impact on the overall assessment of the adaptation process. The adaptation period is often too short, which translates into the lack of readiness to work for new employees.

Parole chiave

  • socio-professional adaptation
  • nurses
  • adaptation in hospitals
Accesso libero

Nicotine addiction – a health problem in adolescents in a neurobiological context

Pubblicato online: 17 Oct 2022
Pagine: 21 - 24

Astratto

Abstract

Smoking is one of the leading causes of death which can be prevented in the developed countries. Smoking begins mainly in adolescence. Smoking in early adolescence is known to be associated with an increased risk of later addiction. Also the growing popularity of e-cigarettes, which attract young people with a variety of flavors, and are still little associated with harmful effects on health, unlike regular cigarettes. Exposure to nicotine in young people can affect learning, memory and attention, and lead to increased impulsivity, mood disorders and drug dependence. Nicotine and its derivatives are harmful to the human body, causing a significant increase in blood pressure, deterioration of blood supply to the vessels and acceleration of atherosclerotic processes, it has a detrimental effect on the gastric mucosa, causing gastric disorders. In addition, smoking is associated with the risk of many cancers: oral cavity, larynx, esophagus, lung, pancreas, kidney, liver and bladder. Nicotine addiction causes many health, social and financial consequences for the individual and the community as a whole. Multiple nicotine addiction risk SNPs were found in the CHRNA5/A3/B4 gene cluster, with the best reported results for the risk allele derived from the non-synonymous SNP, rs16969968, in CHRNA5. Therefore, in the problem of addiction, including nicotine addiction, it seems important to know the neurobiological factors, including genetic ones, involved in these processes. This could lead to the development of new pharmacological and behavioral treatment strategies in the future.

Parole chiave

  • nicotine addiction
  • health problem
  • gene
  • adolescents
Accesso libero

The role of the OPRM1 gene polymorphism and its methylation in people in dependence on substances and with different intensity of pain

Pubblicato online: 17 Oct 2022
Pagine: 25 - 30

Astratto

Abstract

Opioid receptors belong to the group of Gi and Go coupled receptors, inhibiting the activity of the neuron. Opioid receptors regulate reward and aversion. The opioid system contributes to self and species survival by promoting reward elicited by natural stimuli (such as food, sex and social interaction), regulating mood states and facilitating efficient coping with pain and stress. It is suggested that OPRM1 polymorphism is associated with alcohol consumption especially increased in the case of G alleles subjects than A-alleles homozygotes. In several studies, OPRM1 methylation was suspected to be predictive factor of opioid dependence in pain treatment.

The relationship of postoperative or preoperative pain with methylation of some CpG sites in the OPRM1 promoter has also been demonstrated. It is known that OPRM1 SNPs provide changes in the structure of the MOR receptor, so by confirming the pharmacogenetic effects of OPRM1 polymorphisms and using these results to guide therapeutic decisions, patients can be prescribed treatment options with the best efficacy and greatest tolerance. Pharmacogenomics of OPRM1 can improve pain management by predicting individual response to pain medications before treatment and facilitate the development of new and more effective pain medications for post-operative pain.

Parole chiave

  • polymorphism
  • opioid receptor
  • alcohol dependence
  • analgesia
  • methylation
Accesso libero

The disease X: waiting for the next pandemic

Pubblicato online: 20 Nov 2022
Pagine: 31 - 33

Astratto

Abstract

In 2008 the WHO published a report on infectious diseases against which there is no effective treatment or vaccines and therefore – diseases able to cause pandemic. In addition, so called disease X was mentioned – potentially deadly, with no herd immunity against it, holding pandemic potential, unknown in medicine yet. In 2019 such disease X was COVID-19. There is a plausibility, that next pandemic will be induced by zoonotic RNA virus (alike SARS-CoV-2) infecting people in place of intensified human-animal contacts (like high-density animal farming) without proper legal regulations in terms of animal husbandry and high population density. Also in the past major pandemics in XX and XXI centuries were result of zoonotic transmissions (HIV/AIDS, SARS, MERS, Spanish flu, avian flu, swine flu, Ebola). The key in risk recognising is governments and international healthcare agencies’ reaction – proper countermeasures to control pandemic range should be taken. Animal trade should be legally regulated and deforestation limited. There is also an urgent need for funding R&D studies on diseases listed by the WHO.

Parole chiave

  • zoonosis
  • emergency infectious disease
  • pandemic
  • pathogen

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