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Journal Details
Format
Journal
eISSN
2449-8343
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English

Search

Volume 64 (2018): Issue 1 (March 2018)

Journal Details
Format
Journal
eISSN
2449-8343
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English

Search

5 Articles

Experimental Paper

Open Access

Morphological and chemical variability of common oregano (Origanum vulgare L. subsp. vulgare) occurring in eastern Poland

Published Online: 27 Mar 2018
Page range: 11 - 21

Abstract

Summary

Introduction: Common oregano is an important medicinal and aromatic plant, characterized by a high morphological and chemical variability.

Objective: The aim of the work was to determine the diversity of 14 common oregano populations introduced into ex situ conditions, in respect of morphological and developmental traits as well as content and composition of essential oil in herb.

Methods: Observations and harvest of raw material were performed in the second year of plant vegetation. Morphological and developmental characters were estimated. Total content of essential oil was determined according to European Pharmacopoeia 8th. The composition of essential oil was carried out by gas chromatography.

Results: Populations differed in respect of examined traits, i.a.: plant's height from 52.13 to 88.66 cm, number of stems per plant from 45.6 to 123.3, number of internodes per stem from 4.6 to 9.2. Fresh mass of herb was at a level of 249.0–896.6 g per plant. Total content of essential oil ranged from 0.35 to 0.87%. Sabinene, 1,8-cineole, linalool, p-cymene, β-caryophyllene and caryophyllene oxide were the dominant compounds in essential oil.

Conclusions: Number of stems and fresh mass of herb differentiated examined populations at the highest degree. Most of populations were classified as a sabinyl chemotype rich in sesquiterpenes.

Keywords

  • common oregano
  • populations
  • essential oil
  • chemotypes
  • variability
Open Access

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Published Online: 27 Mar 2018
Page range: 22 - 35

Abstract

Summary

Introduction: In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerance in vivo.

Objective: The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats.

Methods: Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kg b.w.) or vehiculum was administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement.

Results: Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kg b.w. had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.

Conclusions: Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

Keywords

  • salidroside
  • alcohol tolerance
  • rats
  • dose-dependent manner
  • ethanol-induced hypothermia
  • sedative effect
Open Access

Antioxidant properties of Artemisia absinthium accelerate healing of experimental Achilles tendon injury in rabbits

Published Online: 27 Mar 2018
Page range: 36 - 43

Abstract

Summary

Introduction: Delayed tendon healing is still found to be among the complications that occur most often after tendon repair.

Objective: The role of local injection of Artemisia absinthium was evaluated in healing of experimental Achilles tendon injury in rabbits.

Methods:. In nine adult New Zealand rabbits a partial thickness tenotomy was created on both hindlimbs.

A. absinthium extract and normal saline were respectively injected daily to treatment and control groups for three days.

Results: On the day 7 after injury, the tendon sections showed that healing rate in A. absinthium treated group was higher than that in control group. Furthermore, at days 14 and 28, comparison between A. absinthium treated group and control group demonstrated that A. absinthium increased the healing rate but with no significance.

Conclusions: Results of this study have showed that application of A. absinthium extract can improve healing process of damaged Achilles tendon.

Keywords

  • antioxidant
  • Artemisia absinthium
  • Achilles tendon
  • rabbits
Open Access

Attitude of future healthcare professionals towards food supplements

Published Online: 27 Mar 2018
Page range: 44 - 55

Abstract

Summary

Introduction: The use of dietary supplements has been observed for many years. Unfortunately, the status of food supplements and main differences between these and drugs remain unknown to most consumers.

Objective: The purpose of the study was to analyze the opinions of future healthcare professionals on dietary supplements, their behavior concerning food supplementation, as well as their knowledge on the safety of these products.

Methods: The survey was conducted among 354 future healthcare professionals, using a questionnaire composed of 21 items exploring demographic characteristics, knowledge of supplements, reasons for the use of dietary supplement, and recall of the use.

Results: All respondents knew that the purpose of using these products is supplementation. A vast majority of respondents (83.9%) thought that a diet with no supplementation is possible or probably possible. 49.4% of respondents (n=175) declared taking food supplements. The most commonly used ones (68.6%) were products recommended during illness and used to improve the condition of skin, hair, and nails. Moreover, dietary supplements mentioned by students included those containing herbal ingredients, such as: Equisetum arvense, Allium sativum, Panax ginseng, and Ginkgo biloba. Most of respondents buy dietary supplements at pharmacies (89.14%).

Conclusions: Use of dietary supplements is widespread among students. Future healthcare professionals have a better knowledge on food supplementation than population of Poland in general, however, they still need good education in this matter.

Keywords

  • food supplements
  • health care professionals
  • herbal substances

Review Papers

Open Access

Lichens as a source of chemical compounds with anti-inflammatory activity

Published Online: 27 Mar 2018
Page range: 56 - 64

Abstract

Summary

Symptoms of inflammation accompany a number of diseases. In order to mitigate them, folk medicine has used a variety of medicinal substances, including herbs and mushrooms. Lichens are less known organisms, containing specific secondary metabolites with interesting biological properties. One of their biological actions is the anti-inflammatory activity that has been confirmed by in vitro and animal studies. It has been proven that compounds and extracts from lichens inhibit the enzymes involved in the inflammatory process. The following paper is a review of research on the little-known anti-inflammatory properties of lichens.

Keywords

  • lichen compounds
  • lichen extracts
  • biological activity
5 Articles

Experimental Paper

Open Access

Morphological and chemical variability of common oregano (Origanum vulgare L. subsp. vulgare) occurring in eastern Poland

Published Online: 27 Mar 2018
Page range: 11 - 21

Abstract

Summary

Introduction: Common oregano is an important medicinal and aromatic plant, characterized by a high morphological and chemical variability.

Objective: The aim of the work was to determine the diversity of 14 common oregano populations introduced into ex situ conditions, in respect of morphological and developmental traits as well as content and composition of essential oil in herb.

Methods: Observations and harvest of raw material were performed in the second year of plant vegetation. Morphological and developmental characters were estimated. Total content of essential oil was determined according to European Pharmacopoeia 8th. The composition of essential oil was carried out by gas chromatography.

Results: Populations differed in respect of examined traits, i.a.: plant's height from 52.13 to 88.66 cm, number of stems per plant from 45.6 to 123.3, number of internodes per stem from 4.6 to 9.2. Fresh mass of herb was at a level of 249.0–896.6 g per plant. Total content of essential oil ranged from 0.35 to 0.87%. Sabinene, 1,8-cineole, linalool, p-cymene, β-caryophyllene and caryophyllene oxide were the dominant compounds in essential oil.

Conclusions: Number of stems and fresh mass of herb differentiated examined populations at the highest degree. Most of populations were classified as a sabinyl chemotype rich in sesquiterpenes.

Keywords

  • common oregano
  • populations
  • essential oil
  • chemotypes
  • variability
Open Access

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Published Online: 27 Mar 2018
Page range: 22 - 35

Abstract

Summary

Introduction: In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerance in vivo.

Objective: The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats.

Methods: Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kg b.w.) or vehiculum was administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement.

Results: Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kg b.w. had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.

Conclusions: Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

Keywords

  • salidroside
  • alcohol tolerance
  • rats
  • dose-dependent manner
  • ethanol-induced hypothermia
  • sedative effect
Open Access

Antioxidant properties of Artemisia absinthium accelerate healing of experimental Achilles tendon injury in rabbits

Published Online: 27 Mar 2018
Page range: 36 - 43

Abstract

Summary

Introduction: Delayed tendon healing is still found to be among the complications that occur most often after tendon repair.

Objective: The role of local injection of Artemisia absinthium was evaluated in healing of experimental Achilles tendon injury in rabbits.

Methods:. In nine adult New Zealand rabbits a partial thickness tenotomy was created on both hindlimbs.

A. absinthium extract and normal saline were respectively injected daily to treatment and control groups for three days.

Results: On the day 7 after injury, the tendon sections showed that healing rate in A. absinthium treated group was higher than that in control group. Furthermore, at days 14 and 28, comparison between A. absinthium treated group and control group demonstrated that A. absinthium increased the healing rate but with no significance.

Conclusions: Results of this study have showed that application of A. absinthium extract can improve healing process of damaged Achilles tendon.

Keywords

  • antioxidant
  • Artemisia absinthium
  • Achilles tendon
  • rabbits
Open Access

Attitude of future healthcare professionals towards food supplements

Published Online: 27 Mar 2018
Page range: 44 - 55

Abstract

Summary

Introduction: The use of dietary supplements has been observed for many years. Unfortunately, the status of food supplements and main differences between these and drugs remain unknown to most consumers.

Objective: The purpose of the study was to analyze the opinions of future healthcare professionals on dietary supplements, their behavior concerning food supplementation, as well as their knowledge on the safety of these products.

Methods: The survey was conducted among 354 future healthcare professionals, using a questionnaire composed of 21 items exploring demographic characteristics, knowledge of supplements, reasons for the use of dietary supplement, and recall of the use.

Results: All respondents knew that the purpose of using these products is supplementation. A vast majority of respondents (83.9%) thought that a diet with no supplementation is possible or probably possible. 49.4% of respondents (n=175) declared taking food supplements. The most commonly used ones (68.6%) were products recommended during illness and used to improve the condition of skin, hair, and nails. Moreover, dietary supplements mentioned by students included those containing herbal ingredients, such as: Equisetum arvense, Allium sativum, Panax ginseng, and Ginkgo biloba. Most of respondents buy dietary supplements at pharmacies (89.14%).

Conclusions: Use of dietary supplements is widespread among students. Future healthcare professionals have a better knowledge on food supplementation than population of Poland in general, however, they still need good education in this matter.

Keywords

  • food supplements
  • health care professionals
  • herbal substances

Review Papers

Open Access

Lichens as a source of chemical compounds with anti-inflammatory activity

Published Online: 27 Mar 2018
Page range: 56 - 64

Abstract

Summary

Symptoms of inflammation accompany a number of diseases. In order to mitigate them, folk medicine has used a variety of medicinal substances, including herbs and mushrooms. Lichens are less known organisms, containing specific secondary metabolites with interesting biological properties. One of their biological actions is the anti-inflammatory activity that has been confirmed by in vitro and animal studies. It has been proven that compounds and extracts from lichens inhibit the enzymes involved in the inflammatory process. The following paper is a review of research on the little-known anti-inflammatory properties of lichens.

Keywords

  • lichen compounds
  • lichen extracts
  • biological activity

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