- Journal Details
- Format
- Journal
- eISSN
- 2544-3577
- First Published
- 01 Oct 2009
- Publication timeframe
- 4 times per year
- Languages
- English
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0 Articles
- Open Access
The Contribution of Endothelial Marker Proteins in the Determination of Vascular Angiogenic Potential, in Normal Physiological Conditions and in Neoplasia
Published Online: 15 Oct 2014
Page range: 69 - 83
Abstract
Recently, the most significant studies in the field of angiogenesis are related to trials concerning the evaluation of the prognostic significance of endothelial markers. By using an estimation of the expression of endothelial cell markers, immunohistochemical studies can assess for the continuity of the vascular intima, as well as allow for the distinction of early, late and mature forms of endothelial cells. The determination of the endothelial cell phenotype using markers such as CD34, CD31, CD133, e-NOS and von Willebrand factor may provide a valuable tool for the monitoring of both normal physiology as well as neoplastic diseases.
Keywords
- endothelium
- angiogenesis
- progenitor cells
- endothelial markers (CD31
- CD34
- CD133
- endothelial Nitric Oxide Synthase
- von Willebrand factor)