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Rare disease day in Slovakia, Europlan national conference

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Conference abstracts, Rare disease day, conference 29.2.2012, First Slovak conference about rare diseases

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Clinical Pharmacy in the Slovak Republic, dedicated to the associated professor Lívia Magulová, PhD.

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Detalles de la revista
Formato
Revista
eISSN
2453-6725
Publicado por primera vez
25 Nov 2011
Periodo de publicación
2 veces al año
Idiomas
Inglés

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Volumen 63 (2016): Edición 2 (December 2016)

Detalles de la revista
Formato
Revista
eISSN
2453-6725
Publicado por primera vez
25 Nov 2011
Periodo de publicación
2 veces al año
Idiomas
Inglés

Buscar

6 Artículos

Original research article

access type Acceso abierto

The Assessment of Patient Satisfaction and Attendance of Community Pharmacies in Slovakia

Publicado en línea: 07 Feb 2017
Páginas: 23 - 29

Resumen

Abstract

Aim: Patient-oriented pharmaceutical care in pharmacies could improve patient satisfaction and influence patient’s choice of a community pharmacy. The aim of the work was to assess patient satisfaction and attendance in community pharmacies in Slovakia. Methods: A self-administered, anonymous questionnaire was distributed to patients visiting 33 community pharmacies in a total of 23 Slovak cities during October-December 2013. The questionnaire contained 29 items and three dimensions were supposed (managing therapy, interpersonal relationship, general satisfaction). A 5-point Likert-type scale (1 = very satisfied, 2 = satisfied, 3 = neither satisfied nor dissatisfied, 4 = dissatisfied, 5 = very dissatisfied) was used for assessing patient satisfaction. The results are presented in percentages and by the level of satisfaction within the range: high satisfaction (score 1.00-2.50), moderate satisfaction (score 2.51-3.50) and low satisfaction (score 3.51-5.00). Reasons for attendance in the community pharmacy and factors influencing pharmacy choice were evaluated either. Results: A total 2 844 respondents were included into the survey. Patient satisfaction with pharmaceutical care achieved high satisfaction level: interpersonal relationship (1.85 ± 0.598; 86.7% highly satisfied respondents) and general satisfaction (2.02 ± 0.643; 71.3% highly satisfied respondents). Managing therapy scored lower (2.24 ± 0.704; 65.4% highly satisfied respondents). The most frequently reported reasons for attending community pharmacy were to obtain prescription (70.4%) and over-the-counter medications (70.4%). The patient choice of a particular pharmacy was influenced by its location (74.1%). Conclusion: This study presents the first nationwide patientreported outcomes about patient satisfaction and attendance in community pharmacies in Slovakia. Future development and advancement of pharmacy practice leading to higher patient satisfaction requires modification of community pharmacists’ professional behaviour in Slovakia namely in managing therapy of patients.

Palabras clave

  • Pharmaceutical care - Community pharmacy - Patient satisfaction - Managing therapy - Pharmacy choice - Patient-reported outcomes
access type Acceso abierto

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Publicado en línea: 07 Feb 2017
Páginas: 30 - 36

Resumen

Abstract

In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used electrical conductivity for the determination of critical micelle concentration at different temperatures (T = 293.15 - 313.15 K), as well as calculated thermodynamic parameters like standard Gibbs free energy, enthalpy and entropy of micellization. According to contribution of Gibbs free energy is the process of micellization primarily controlled by entropy. Solubilization of valsartan was studied in surfactant system at 298.15 K and physiological conditions pH 7.4 using UV-spectrophotometry at different concentration range (0.001 - 0.07 mol/l) of sodium dodecyl sulphate. The solubilization of drug was observed with increasing concentration of surfactant in aqueous solution.

Palabras clave

  • Valsartan - sodium dodecyl sulphate - critical micelle concentration - micellization - thermodynamics - solubilization
access type Acceso abierto

Virtual screening of combinatorial library of novel benzenesulfonamides on mycobacterial carbonic anhydrase II

Publicado en línea: 07 Feb 2017
Páginas: 1 - 6

Resumen

Abstract

Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) isoforms with an aim to find drug candidates with selective activity on mtCA II. The predicted selectivity was calculated based on optimized MM-GBSA free energies for ligand enzyme interactions. Selectivity, LogP (o/w) and interaction energy were used to calculate the selection index which determined the subset of best scoring molecules selected for further evaluation. Structure-activity relationship was found for fragment subsets, showing us the possible way regarding how to influence lipophilicity without affecting ligand-enzyme binding properties.

Palabras clave

  • Tuberculosis - carbonic anhydrase inhibitors - virtual screening - ADME prediction
access type Acceso abierto

Cola millenii Leaf Ethyl Acetate Extract: Fourier Transform Infrared (FTIR) Spectroscopy; Modulatory Effect on Serum Indices and Redox Biomarkers

Publicado en línea: 07 Feb 2017
Páginas: 7 - 11

Resumen

Abstract

The ethyl acetate extract of the leaves of Cola millenii were investigated for it secondary metabolites as well as its effect on serum indices and antioxidant status in normal male albino rats. Fresh leaves of C. millenii were air dried, extracted with ethyl acetate and concentrated. The extract was analysed for its secondary metabolites using the Fourier transform infrared (FTIR) spectroscopy. Three concentrates consisting of 50, 100, and 200 mg/kg body weight (bw) of the extract were prepared. Groups of five rats were intraperitoneally injected with each of the doses, whilst a fourth group was not injected and served as the normal control. After 7 days, the rats were sacrificed by cervical dislocation. Blood serum was analysed for hepatic and renal biomarkers as well as cholesterol level. Hepatic tissue was analysed for malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT). FITR spectroscopy revealed the presence of aliphatic, carboxylic acids, esters and alkenes functional groups. Administration of the extract doses led to the increased serum activities of hepatic and renal biomarkers. About 50 mg/kg bw of the extract had the least cholesterol level compared to the other doses. MDA level was significantly (p < 0.05) reduced in rats administered with 50 mg/kg bw of the extract. Except for the lowest dose, little or no significant effect was observed on SOD and CAT activities. These results indicate the medicinal potential of ethyl acetate extract of C. millenii leaves as portrayed by the low cholesterol and MDA levels and increased CAT activity with 50 mg/kg bw being the most active concentration.

Palabras clave

  • Anti-oxidative stress -Cola milleni - Medicinal plants

Original research paper

access type Acceso abierto

Financial aspects of community pharmacies in Slovakia (2009-2014) Finančné aspekty verejných lekární na Slovensku v rokoch 2009-2014

Publicado en línea: 07 Feb 2017
Páginas: 12 - 17

Resumen

Abstract

Community pharmacies play an important role in the process of ensuring public health. Pharmacists provide pharmaceutical care that includes acquiring, storing, preparing, reviewing and dispensing medicines, medical devices and dietary food to the inhabitants; providing them with information and advice; acquiring, storing and dispensing additional assortment; carrying out physical and biochemical testing for primary prevention and monitoring of drug efficacy and safety. At present, there are constant changes which have direct or potential and often negative impact on community pharmacies. For providing affordable and good quality pharmaceutical care, it is important to continuously monitor and analyse the developments in the financial data in community pharmacy business management. The data file from 2009-2014 on financial performance of selected community pharmacies were obtained from the Register of Financial Statements at Ministry of Finance Slovak Republic. A group of 194 community pharmacies were selected that represented more than 10 percent of all pharmacies. The selection criteria respected the territorial division of the Slovak Republic on districts, the size of municipalities (cities and villages) and location (at or near health centres, shopping centres, housing estates, etc.). The evaluation parameters were gross profit, net profit, revenue from sales of goods and services, operating expenses, total assets, inventory, short-term receivables, total receivables, financial assets, owner’s equity, total liabilities, current liabilities and their characteristics (25th, 50th, 75th percentile, minimum, maximum, mean). The financial parameters obtained and their characteristics presented the basic information on the management of community pharmacies. The data also provided information for further assessment on factors that might have an impact on their value and direction of evolution.

Palabras clave

  • community pharmacy - management - financial aspects

Review

access type Acceso abierto

Autoimmune rheumatic diseases and Klinefelter syndrome Autoimunitné reumatické choroby a Klinefelterov syndróm

Publicado en línea: 07 Feb 2017
Páginas: 18 - 22

Resumen

Abstract

The article summarizes data on the association of Klinefelter syndrome (KS) with autoimmune rheumatic diseases, that is rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, systemic sclerosis (SSc), mixed connective tissue diseases (MCTD), Sjogren’s syndrome and antiphospholipid syndrome (APS). Recently, a higher risk for RA, SLE and Sjogren’s syndrome in patients with KS has been clearly demonstrated. However, the association of other autoimmune rheumatic disorders such as dermatomyositis/polymyositis, SSc, MCTD and APS is reported only casually. Based on the hormonal changes in KS, there are suggestions that low androgen and higher estrogen levels might be a predisposing factor for the development of autoimmune diseases, but evidence for the association is poor. Epidemiologic studies on larger cohorts of patients are required.

Palabras clave

  • Klinefelter syndrome - rheumatoid arthritis - polymyositis/dermatomyositis - systemic lupus erythematosus - systemic sclerosis - antiphospholipid syndrome
6 Artículos

Original research article

access type Acceso abierto

The Assessment of Patient Satisfaction and Attendance of Community Pharmacies in Slovakia

Publicado en línea: 07 Feb 2017
Páginas: 23 - 29

Resumen

Abstract

Aim: Patient-oriented pharmaceutical care in pharmacies could improve patient satisfaction and influence patient’s choice of a community pharmacy. The aim of the work was to assess patient satisfaction and attendance in community pharmacies in Slovakia. Methods: A self-administered, anonymous questionnaire was distributed to patients visiting 33 community pharmacies in a total of 23 Slovak cities during October-December 2013. The questionnaire contained 29 items and three dimensions were supposed (managing therapy, interpersonal relationship, general satisfaction). A 5-point Likert-type scale (1 = very satisfied, 2 = satisfied, 3 = neither satisfied nor dissatisfied, 4 = dissatisfied, 5 = very dissatisfied) was used for assessing patient satisfaction. The results are presented in percentages and by the level of satisfaction within the range: high satisfaction (score 1.00-2.50), moderate satisfaction (score 2.51-3.50) and low satisfaction (score 3.51-5.00). Reasons for attendance in the community pharmacy and factors influencing pharmacy choice were evaluated either. Results: A total 2 844 respondents were included into the survey. Patient satisfaction with pharmaceutical care achieved high satisfaction level: interpersonal relationship (1.85 ± 0.598; 86.7% highly satisfied respondents) and general satisfaction (2.02 ± 0.643; 71.3% highly satisfied respondents). Managing therapy scored lower (2.24 ± 0.704; 65.4% highly satisfied respondents). The most frequently reported reasons for attending community pharmacy were to obtain prescription (70.4%) and over-the-counter medications (70.4%). The patient choice of a particular pharmacy was influenced by its location (74.1%). Conclusion: This study presents the first nationwide patientreported outcomes about patient satisfaction and attendance in community pharmacies in Slovakia. Future development and advancement of pharmacy practice leading to higher patient satisfaction requires modification of community pharmacists’ professional behaviour in Slovakia namely in managing therapy of patients.

Palabras clave

  • Pharmaceutical care - Community pharmacy - Patient satisfaction - Managing therapy - Pharmacy choice - Patient-reported outcomes
access type Acceso abierto

Influence of Valsartan on the thermodynamics of micellization of anionic surfactant Sodium Dodecyl Sulphate

Publicado en línea: 07 Feb 2017
Páginas: 30 - 36

Resumen

Abstract

In this manuscript was investigated behaviour of drug valsartan by micellar media of anionic surfactant sodium dodecyl sulphate. As the method was used electrical conductivity for the determination of critical micelle concentration at different temperatures (T = 293.15 - 313.15 K), as well as calculated thermodynamic parameters like standard Gibbs free energy, enthalpy and entropy of micellization. According to contribution of Gibbs free energy is the process of micellization primarily controlled by entropy. Solubilization of valsartan was studied in surfactant system at 298.15 K and physiological conditions pH 7.4 using UV-spectrophotometry at different concentration range (0.001 - 0.07 mol/l) of sodium dodecyl sulphate. The solubilization of drug was observed with increasing concentration of surfactant in aqueous solution.

Palabras clave

  • Valsartan - sodium dodecyl sulphate - critical micelle concentration - micellization - thermodynamics - solubilization
access type Acceso abierto

Virtual screening of combinatorial library of novel benzenesulfonamides on mycobacterial carbonic anhydrase II

Publicado en línea: 07 Feb 2017
Páginas: 1 - 6

Resumen

Abstract

Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) isoforms with an aim to find drug candidates with selective activity on mtCA II. The predicted selectivity was calculated based on optimized MM-GBSA free energies for ligand enzyme interactions. Selectivity, LogP (o/w) and interaction energy were used to calculate the selection index which determined the subset of best scoring molecules selected for further evaluation. Structure-activity relationship was found for fragment subsets, showing us the possible way regarding how to influence lipophilicity without affecting ligand-enzyme binding properties.

Palabras clave

  • Tuberculosis - carbonic anhydrase inhibitors - virtual screening - ADME prediction
access type Acceso abierto

Cola millenii Leaf Ethyl Acetate Extract: Fourier Transform Infrared (FTIR) Spectroscopy; Modulatory Effect on Serum Indices and Redox Biomarkers

Publicado en línea: 07 Feb 2017
Páginas: 7 - 11

Resumen

Abstract

The ethyl acetate extract of the leaves of Cola millenii were investigated for it secondary metabolites as well as its effect on serum indices and antioxidant status in normal male albino rats. Fresh leaves of C. millenii were air dried, extracted with ethyl acetate and concentrated. The extract was analysed for its secondary metabolites using the Fourier transform infrared (FTIR) spectroscopy. Three concentrates consisting of 50, 100, and 200 mg/kg body weight (bw) of the extract were prepared. Groups of five rats were intraperitoneally injected with each of the doses, whilst a fourth group was not injected and served as the normal control. After 7 days, the rats were sacrificed by cervical dislocation. Blood serum was analysed for hepatic and renal biomarkers as well as cholesterol level. Hepatic tissue was analysed for malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT). FITR spectroscopy revealed the presence of aliphatic, carboxylic acids, esters and alkenes functional groups. Administration of the extract doses led to the increased serum activities of hepatic and renal biomarkers. About 50 mg/kg bw of the extract had the least cholesterol level compared to the other doses. MDA level was significantly (p < 0.05) reduced in rats administered with 50 mg/kg bw of the extract. Except for the lowest dose, little or no significant effect was observed on SOD and CAT activities. These results indicate the medicinal potential of ethyl acetate extract of C. millenii leaves as portrayed by the low cholesterol and MDA levels and increased CAT activity with 50 mg/kg bw being the most active concentration.

Palabras clave

  • Anti-oxidative stress -Cola milleni - Medicinal plants

Original research paper

access type Acceso abierto

Financial aspects of community pharmacies in Slovakia (2009-2014) Finančné aspekty verejných lekární na Slovensku v rokoch 2009-2014

Publicado en línea: 07 Feb 2017
Páginas: 12 - 17

Resumen

Abstract

Community pharmacies play an important role in the process of ensuring public health. Pharmacists provide pharmaceutical care that includes acquiring, storing, preparing, reviewing and dispensing medicines, medical devices and dietary food to the inhabitants; providing them with information and advice; acquiring, storing and dispensing additional assortment; carrying out physical and biochemical testing for primary prevention and monitoring of drug efficacy and safety. At present, there are constant changes which have direct or potential and often negative impact on community pharmacies. For providing affordable and good quality pharmaceutical care, it is important to continuously monitor and analyse the developments in the financial data in community pharmacy business management. The data file from 2009-2014 on financial performance of selected community pharmacies were obtained from the Register of Financial Statements at Ministry of Finance Slovak Republic. A group of 194 community pharmacies were selected that represented more than 10 percent of all pharmacies. The selection criteria respected the territorial division of the Slovak Republic on districts, the size of municipalities (cities and villages) and location (at or near health centres, shopping centres, housing estates, etc.). The evaluation parameters were gross profit, net profit, revenue from sales of goods and services, operating expenses, total assets, inventory, short-term receivables, total receivables, financial assets, owner’s equity, total liabilities, current liabilities and their characteristics (25th, 50th, 75th percentile, minimum, maximum, mean). The financial parameters obtained and their characteristics presented the basic information on the management of community pharmacies. The data also provided information for further assessment on factors that might have an impact on their value and direction of evolution.

Palabras clave

  • community pharmacy - management - financial aspects

Review

access type Acceso abierto

Autoimmune rheumatic diseases and Klinefelter syndrome Autoimunitné reumatické choroby a Klinefelterov syndróm

Publicado en línea: 07 Feb 2017
Páginas: 18 - 22

Resumen

Abstract

The article summarizes data on the association of Klinefelter syndrome (KS) with autoimmune rheumatic diseases, that is rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, systemic sclerosis (SSc), mixed connective tissue diseases (MCTD), Sjogren’s syndrome and antiphospholipid syndrome (APS). Recently, a higher risk for RA, SLE and Sjogren’s syndrome in patients with KS has been clearly demonstrated. However, the association of other autoimmune rheumatic disorders such as dermatomyositis/polymyositis, SSc, MCTD and APS is reported only casually. Based on the hormonal changes in KS, there are suggestions that low androgen and higher estrogen levels might be a predisposing factor for the development of autoimmune diseases, but evidence for the association is poor. Epidemiologic studies on larger cohorts of patients are required.

Palabras clave

  • Klinefelter syndrome - rheumatoid arthritis - polymyositis/dermatomyositis - systemic lupus erythematosus - systemic sclerosis - antiphospholipid syndrome

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