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Rare disease day in Slovakia, Europlan national conference

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Conference abstracts, Rare disease day, conference 29.2.2012, First Slovak conference about rare diseases

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Clinical Pharmacy in the Slovak Republic, dedicated to the associated professor Lívia Magulová, PhD.

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Detalles de la revista
Formato
Revista
eISSN
2453-6725
Publicado por primera vez
25 Nov 2011
Periodo de publicación
2 veces al año
Idiomas
Inglés

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Volumen 62 (2015): Edición 1 (June 2015)

Detalles de la revista
Formato
Revista
eISSN
2453-6725
Publicado por primera vez
25 Nov 2011
Periodo de publicación
2 veces al año
Idiomas
Inglés

Buscar

7 Artículos
Acceso abierto

Selected Issues of Legislation with regard to Operating Pharmacies in the Slovak Republic / Vybrané problémy právnej úpravy prevádzkovania lekární v podmienkach Slovenskej republiky

Publicado en línea: 22 Jun 2015
Páginas: 1 - 8

Resumen

Abstract

Among the basic rights and freedoms, stipulated in the Constitution of the Slovak Republic, are right to protection of health, free medical care based on health insurance, right to medical aids under conditions stipulated by law. These rights are guaranteed through provisions of Art. 40 of the Constitution of the Slovak Republic as part of Economic, Social and Cultural Rights and they apply to every individual. Since these rights are considered to be human rights under the international law, they are guaranteed by multilateral treaties in which Slovak Republic is a signatory, such as International Covenant on Economic, Social and Cultural Rights.

Legal regulation of operating pharmacies in the Slovak Republic covers a broad scope of issues and is quite extensive. Through concerted legislative effort, the legislator had tried to set rules that would make the legal environment in this sector more transparent and easier to navigate through. In some areas, the rules were set by the legislature of the European Union (EU) and the Slovak legislature only adapted them. The most important aspect of legal regulation in this sphere that is not completely regulated by the EU legislature is providing pharmaceutical care and usage of the public health insurance system with regard to providing pharmaceutical care.

The main aim of this study is to point out select issues that are associated with the position of a pharmacy operator and obligations stipulated in the Medicines Act 2011 that must be observed and incorporated into the running of a pharmacy. This area of business is fairly strictly regulated and therefore it is necessary to get acquainted with the relevant legislation. The study addresses several issues regulated by the Medicines Act 2011 or the Appropriate Pharmaceutical Practice Regulation 2012 from the legal-theoretical perspective.

Palabras clave

  • retail pharmacy - Medicines Act - pharmacy - pharmaceutical care

Kľúčové slová

  • lekáreň - zákon o liekoch - farmácia - lekárenská starostlivosť
Acceso abierto

The exploitation of micromorphological parameters for identification in the section / Mentha Využitie mikromorfologických parametrov pri identifikácii v sekcii Mentha

Publicado en línea: 22 Jun 2015
Páginas: 9 - 14

Resumen

Abstract

The identification of species in the genus Mentha is especially difficult because of the ease of hybridization, favoured by gynodioecy, which is further complicated by polymorphism, cultivation, polyploidy and vegetative propagation. This all explains the genicpopulation and microevolutionary background for variability of mints. In this work we studied the usage of micromorphological and phytochemical parameters in identification and characterization of selected Mentha species. On abaxial surface of leaves of 20 Mentha populations we determined the size and the number of peltate glandular trichomes. The essential oil was analysed by GC MS. We identified and characterized populations of M. × piperita, M. spicata, M. spicata subsp. condensata, M. spicata var. crispa, M. spicata var. citrata, M. × gentilis, M. aquatic, M. arvensis amd M. longifolia. The size and the number of peltate glandular trichomes contribute to characterisation of some Mentha species (especially in M. longifolia and M. × piperita).

Palabras clave

  • Mentha - peltate glandular trichomes - quantitative microscopy - essential oil - GC MS

Kľúčové slová

  • Mentha - žliazky typu Lamiaceae - kvantitativna mikroskopia - silica - GC MS
Acceso abierto

Medication review in inpatients at cardiology clinic / Prehodnotenie terapie u hospitalizovaných pacientov na kardiologickej klinike

Publicado en línea: 22 Jun 2015
Páginas: 15 - 19

Resumen

Abstract

This study deals with effect of hospital pharmacist on solving drug-related problems (DRP) in inpatients. The study was carried out as a prospective 5-week study at the Cardiology Clinic, Teaching Hospital, Nitra. The study group included 73 inpatients. Pharmacotherapy of each patient was analysed for DRP within 24-48 h after admission. Information on patients was collected from electronic database, medical reports, communication with attending doctors and ward rounds. Patients’ age, medical history, diagnoses, medication prescribed during hospitalisation and laboratory test results were assessed for further pharmacotherapy rationalisation. Pharmaceutical Care Network Europe (PCNE) classification scheme for DRP V6.2 was used to characterise DRP. There were 36 DRP identified in 37% inpatients (n = 27). The most frequent causes of DRP were dose-related (n = 13; 26%) and use

Palabras clave

  • medication reconciliation - inpatient - PCNE - DRP - clinical pharmacist

Kľúčové slová

  • prehodnotenie medikácie - hospitalizovaný pacient - PCNE - DRP - klinický farmaceut
Acceso abierto

Prosperity of community pharmacy evaluated by gross and net profit and suggested corrective measures. 10 years study / Prosperita verejnej lekárne hodnotená prostredníctvom hrubého a čistého zisku a opatrenia vedúce k ich náprave. 10 ročná štúdia

Publicado en línea: 22 Jun 2015
Páginas: 20 - 24

Resumen

Abstract

Monitoring, calculation and assessment of community pharmacy prosperity with the help of financial analysis indicators for years 2003-2012, using financial statements was conducted, with respect to profitability parameters such as gross and net profit ratios. These ratios reflect various changes that hold between years 2003 and 2012. Under the time of financial crisis, recession and serious socioeconomic changes the profitability parameter gross profit ranged from x2003-2011=14.3-22.8% (average=19.2%, mean=19.8%, σ=2.4), but in 2012 decreased on 14.3%. Net profit ranged x2003-2011 = 2.3-18.3% (average=14.6%, mean =16.6%, σ = 4.9), while in 2012 reached only 2.3%. All changes that have taken place in the society had impact on community pharmacy finance by worsening its profitability. Therefore, the stability of community pharmacy may be threatened and may affect its future performance.

Palabras clave

  • community pharmacy - prosperity - financial analysis - gross profit - net profit - corrective measures - financial crisis

Slovak abstract

  • Monitorovanie
  • výpočet a hodnotenie prosperity verejnej lekárne pomocou metódy bolo uskutočnené za roky 2003 - 2012. Počítané boli ukazovatele ziskovosti
  • ako hrubý zmeny
  • ktoré nastali v rokoch 2003 až 2012. V dôsledku finančnej krízy
  • recesie a vážnych hrubého zisku pohyboval v rozpätí x2003-2011 = 14,3 - 22,8 % (priemer = 19,2 %
  • median 14,3 %. Ukazovateľ čistého zisku sa pohyboval v rozpätí x2003-2011 = 0 - 18,3 % (priemer čo v roku 2012 dosiahol len 2,3 %. Zmeny ktoré prebehli v spoločnosti mali dopad zhoršením jej ziskovosti
  • a tým ohrozením stability verejnej lekárne do budúcnosti.
Acceso abierto

Consumer satisfaction with pharmaceutical care in Slovak community pharmacies / Spokojnosť klientov lekární s lekárenskou starostlivosťou na Slovensku

Publicado en línea: 22 Jun 2015
Páginas: 25 - 30

Resumen

Abstract

The aim of this pilot study was to evaluate consumer satisfaction with pharmaceutical care provided in community pharmacies at the region level. Expectations and opinions of consumers were also confronted with the assumptions of pharmacists. Up to 82.0% of consumers confirmed their satisfaction with the care given to them by the pharmacist. A key factor of consumer satisfaction has been the professional (78.7%) and human approach (83.5%) of the pharmacist. A total of 73.6% of consumers in the survey accepted the pharmacist as an expert in medicines. The pharmacist´s self-evaluation was more negative. Monitoring and evaluation of consumer satisfactory with pharmaceutical care is not only essential for improvement of the quality of the healthcare system and for the implementation of pharmaceutical care focussed on the patient, but it may influence the economic and financial outcomes of entities providing pharmaceutical care in community pharmacies.

Palabras clave

  • Consumer - Pharmacist - Satisfaction - Pharmaceutical Care - Community Pharmacy

Kľučove slova

  • spotrebiteľ - lekárnik - spokojnosť - lekárenská starostlivosť - verejná lekáreň
Acceso abierto

Comparison of two RP-HPLC methods for determination of recombinant human thrombin in pharmaceutical formulations. / Porovnanie dvoch RP-HPLC metód pre stanovenie rekombinantného ľudského trombínu vo farmaceutických formuláciách

Publicado en línea: 22 Jun 2015
Páginas: 31 - 39

Resumen

Abstract

Two reversed-phase high performance liquid chromatography analytical methods (Method I and Method II) for determination of assay of recombinant human thrombin in pharmaceutical formulations were developed and validated. Analysis was performed on chromatographic system Agilent 1200 series SL with diode array detection and mass selective detection.

Method I was intended for faster determination of thrombin assay. Gradient programme was optimised to achieve sufficient separation and acceptable runtime. Chromatographic analysis was performed on analytical column Grace Vydac, C4 250 × 4.6 mm, 5 mm. Method II is Method I adapted to use the mass selective detector. Chromatographic separation was performed on analytical column Zorbax 300SB-C8 SolvSaver Plus, 150 × 3 mm, 3.5 mm. Both analytical methods were validated with respect to specificity, linearity, precision and accuracy. The response of thrombin was a linear function of concentration over the range 0.1-1.0 mg/ml. Precision and accuracy of thrombin was evaluated at three concentration levels low (0.2 mg/ml), medium (0.4 mg/ml) and high (0.8 mg/ml).

Both validated methods have been successfully applied for determination of assay and thrombin degradation products in pharmaceutical formulations.

Keywords

  • Thrombin - RP-HPLC - chromatography - mass spectrometry

Kľúčové slová

  • trombín - RP-HPLC - chromatografia - hmotnostná spektrometria
Acceso abierto

Hydroxycinnamic derivatives content in plant organs linked to harvest time of Salvia officinalis L. cv. ‘Krajová’ / Obsah hydroxyškoricových derivátov v rastlinných orgánoch Salvia officinalis L. cv. ‘Krajová’ v závislosti od termínu zberu

Publicado en línea: 22 Jun 2015
Páginas: 40 - 46

Resumen

Abstract

Salvia officinalis L. (sage) is an important essential oil containing Mediterranean medicinal plant that is commonly cultivated for pharmaceutical uses. In addition to essential oil, other compounds participate on the biological effects of sage, mainly diterpenes, triterpenes and phenolic compounds of the hydroxycinnamic and flavonoid types. Sage essential oil content is known to differ in plant parts, and to be influenced by plant phenophase, climatic and edaphic conditions. This work deals with the study of total hydroxycinnamic derivatives (THD), and specifically rosmarinic acid (RA), content variation in different aerial parts of sage linked to different harvest times. Dry sage leaves (Salviae officinalis folium) THD content was quantified using a pharmacopoeial method, and varied between 3.06 % and 3.52 % in different harvest times, with maxima in youngest plant shoot leaves and newly-grown shoots in September. Sage stems showed similar THD content variations when linked to harvest times, however with lower percentage, 1.33 - 3.04 %. Rosmarinic acid variability showed the same trends, its content ranged between 0.76 % and 1.65 % in leaves, and between 0.19 % and 0.83 % in stems, respectively. Highest percentages of both THD and RA were found in top leaves, lowest in leaves from the middle of the stem. When linked to plant phenophase, the content of THD and RA decreased at flowering time.

Palabras clave

  • Salvia officinalis - THD - rosmarinic acid - plant organ - harvest time

Kľúčové slová

  • Salvia officinalis - THD - kyselina rozmarínová - rastlinná časť - termín zberu
7 Artículos
Acceso abierto

Selected Issues of Legislation with regard to Operating Pharmacies in the Slovak Republic / Vybrané problémy právnej úpravy prevádzkovania lekární v podmienkach Slovenskej republiky

Publicado en línea: 22 Jun 2015
Páginas: 1 - 8

Resumen

Abstract

Among the basic rights and freedoms, stipulated in the Constitution of the Slovak Republic, are right to protection of health, free medical care based on health insurance, right to medical aids under conditions stipulated by law. These rights are guaranteed through provisions of Art. 40 of the Constitution of the Slovak Republic as part of Economic, Social and Cultural Rights and they apply to every individual. Since these rights are considered to be human rights under the international law, they are guaranteed by multilateral treaties in which Slovak Republic is a signatory, such as International Covenant on Economic, Social and Cultural Rights.

Legal regulation of operating pharmacies in the Slovak Republic covers a broad scope of issues and is quite extensive. Through concerted legislative effort, the legislator had tried to set rules that would make the legal environment in this sector more transparent and easier to navigate through. In some areas, the rules were set by the legislature of the European Union (EU) and the Slovak legislature only adapted them. The most important aspect of legal regulation in this sphere that is not completely regulated by the EU legislature is providing pharmaceutical care and usage of the public health insurance system with regard to providing pharmaceutical care.

The main aim of this study is to point out select issues that are associated with the position of a pharmacy operator and obligations stipulated in the Medicines Act 2011 that must be observed and incorporated into the running of a pharmacy. This area of business is fairly strictly regulated and therefore it is necessary to get acquainted with the relevant legislation. The study addresses several issues regulated by the Medicines Act 2011 or the Appropriate Pharmaceutical Practice Regulation 2012 from the legal-theoretical perspective.

Palabras clave

  • retail pharmacy - Medicines Act - pharmacy - pharmaceutical care

Kľúčové slová

  • lekáreň - zákon o liekoch - farmácia - lekárenská starostlivosť
Acceso abierto

The exploitation of micromorphological parameters for identification in the section / Mentha Využitie mikromorfologických parametrov pri identifikácii v sekcii Mentha

Publicado en línea: 22 Jun 2015
Páginas: 9 - 14

Resumen

Abstract

The identification of species in the genus Mentha is especially difficult because of the ease of hybridization, favoured by gynodioecy, which is further complicated by polymorphism, cultivation, polyploidy and vegetative propagation. This all explains the genicpopulation and microevolutionary background for variability of mints. In this work we studied the usage of micromorphological and phytochemical parameters in identification and characterization of selected Mentha species. On abaxial surface of leaves of 20 Mentha populations we determined the size and the number of peltate glandular trichomes. The essential oil was analysed by GC MS. We identified and characterized populations of M. × piperita, M. spicata, M. spicata subsp. condensata, M. spicata var. crispa, M. spicata var. citrata, M. × gentilis, M. aquatic, M. arvensis amd M. longifolia. The size and the number of peltate glandular trichomes contribute to characterisation of some Mentha species (especially in M. longifolia and M. × piperita).

Palabras clave

  • Mentha - peltate glandular trichomes - quantitative microscopy - essential oil - GC MS

Kľúčové slová

  • Mentha - žliazky typu Lamiaceae - kvantitativna mikroskopia - silica - GC MS
Acceso abierto

Medication review in inpatients at cardiology clinic / Prehodnotenie terapie u hospitalizovaných pacientov na kardiologickej klinike

Publicado en línea: 22 Jun 2015
Páginas: 15 - 19

Resumen

Abstract

This study deals with effect of hospital pharmacist on solving drug-related problems (DRP) in inpatients. The study was carried out as a prospective 5-week study at the Cardiology Clinic, Teaching Hospital, Nitra. The study group included 73 inpatients. Pharmacotherapy of each patient was analysed for DRP within 24-48 h after admission. Information on patients was collected from electronic database, medical reports, communication with attending doctors and ward rounds. Patients’ age, medical history, diagnoses, medication prescribed during hospitalisation and laboratory test results were assessed for further pharmacotherapy rationalisation. Pharmaceutical Care Network Europe (PCNE) classification scheme for DRP V6.2 was used to characterise DRP. There were 36 DRP identified in 37% inpatients (n = 27). The most frequent causes of DRP were dose-related (n = 13; 26%) and use

Palabras clave

  • medication reconciliation - inpatient - PCNE - DRP - clinical pharmacist

Kľúčové slová

  • prehodnotenie medikácie - hospitalizovaný pacient - PCNE - DRP - klinický farmaceut
Acceso abierto

Prosperity of community pharmacy evaluated by gross and net profit and suggested corrective measures. 10 years study / Prosperita verejnej lekárne hodnotená prostredníctvom hrubého a čistého zisku a opatrenia vedúce k ich náprave. 10 ročná štúdia

Publicado en línea: 22 Jun 2015
Páginas: 20 - 24

Resumen

Abstract

Monitoring, calculation and assessment of community pharmacy prosperity with the help of financial analysis indicators for years 2003-2012, using financial statements was conducted, with respect to profitability parameters such as gross and net profit ratios. These ratios reflect various changes that hold between years 2003 and 2012. Under the time of financial crisis, recession and serious socioeconomic changes the profitability parameter gross profit ranged from x2003-2011=14.3-22.8% (average=19.2%, mean=19.8%, σ=2.4), but in 2012 decreased on 14.3%. Net profit ranged x2003-2011 = 2.3-18.3% (average=14.6%, mean =16.6%, σ = 4.9), while in 2012 reached only 2.3%. All changes that have taken place in the society had impact on community pharmacy finance by worsening its profitability. Therefore, the stability of community pharmacy may be threatened and may affect its future performance.

Palabras clave

  • community pharmacy - prosperity - financial analysis - gross profit - net profit - corrective measures - financial crisis

Slovak abstract

  • Monitorovanie
  • výpočet a hodnotenie prosperity verejnej lekárne pomocou metódy bolo uskutočnené za roky 2003 - 2012. Počítané boli ukazovatele ziskovosti
  • ako hrubý zmeny
  • ktoré nastali v rokoch 2003 až 2012. V dôsledku finančnej krízy
  • recesie a vážnych hrubého zisku pohyboval v rozpätí x2003-2011 = 14,3 - 22,8 % (priemer = 19,2 %
  • median 14,3 %. Ukazovateľ čistého zisku sa pohyboval v rozpätí x2003-2011 = 0 - 18,3 % (priemer čo v roku 2012 dosiahol len 2,3 %. Zmeny ktoré prebehli v spoločnosti mali dopad zhoršením jej ziskovosti
  • a tým ohrozením stability verejnej lekárne do budúcnosti.
Acceso abierto

Consumer satisfaction with pharmaceutical care in Slovak community pharmacies / Spokojnosť klientov lekární s lekárenskou starostlivosťou na Slovensku

Publicado en línea: 22 Jun 2015
Páginas: 25 - 30

Resumen

Abstract

The aim of this pilot study was to evaluate consumer satisfaction with pharmaceutical care provided in community pharmacies at the region level. Expectations and opinions of consumers were also confronted with the assumptions of pharmacists. Up to 82.0% of consumers confirmed their satisfaction with the care given to them by the pharmacist. A key factor of consumer satisfaction has been the professional (78.7%) and human approach (83.5%) of the pharmacist. A total of 73.6% of consumers in the survey accepted the pharmacist as an expert in medicines. The pharmacist´s self-evaluation was more negative. Monitoring and evaluation of consumer satisfactory with pharmaceutical care is not only essential for improvement of the quality of the healthcare system and for the implementation of pharmaceutical care focussed on the patient, but it may influence the economic and financial outcomes of entities providing pharmaceutical care in community pharmacies.

Palabras clave

  • Consumer - Pharmacist - Satisfaction - Pharmaceutical Care - Community Pharmacy

Kľučove slova

  • spotrebiteľ - lekárnik - spokojnosť - lekárenská starostlivosť - verejná lekáreň
Acceso abierto

Comparison of two RP-HPLC methods for determination of recombinant human thrombin in pharmaceutical formulations. / Porovnanie dvoch RP-HPLC metód pre stanovenie rekombinantného ľudského trombínu vo farmaceutických formuláciách

Publicado en línea: 22 Jun 2015
Páginas: 31 - 39

Resumen

Abstract

Two reversed-phase high performance liquid chromatography analytical methods (Method I and Method II) for determination of assay of recombinant human thrombin in pharmaceutical formulations were developed and validated. Analysis was performed on chromatographic system Agilent 1200 series SL with diode array detection and mass selective detection.

Method I was intended for faster determination of thrombin assay. Gradient programme was optimised to achieve sufficient separation and acceptable runtime. Chromatographic analysis was performed on analytical column Grace Vydac, C4 250 × 4.6 mm, 5 mm. Method II is Method I adapted to use the mass selective detector. Chromatographic separation was performed on analytical column Zorbax 300SB-C8 SolvSaver Plus, 150 × 3 mm, 3.5 mm. Both analytical methods were validated with respect to specificity, linearity, precision and accuracy. The response of thrombin was a linear function of concentration over the range 0.1-1.0 mg/ml. Precision and accuracy of thrombin was evaluated at three concentration levels low (0.2 mg/ml), medium (0.4 mg/ml) and high (0.8 mg/ml).

Both validated methods have been successfully applied for determination of assay and thrombin degradation products in pharmaceutical formulations.

Keywords

  • Thrombin - RP-HPLC - chromatography - mass spectrometry

Kľúčové slová

  • trombín - RP-HPLC - chromatografia - hmotnostná spektrometria
Acceso abierto

Hydroxycinnamic derivatives content in plant organs linked to harvest time of Salvia officinalis L. cv. ‘Krajová’ / Obsah hydroxyškoricových derivátov v rastlinných orgánoch Salvia officinalis L. cv. ‘Krajová’ v závislosti od termínu zberu

Publicado en línea: 22 Jun 2015
Páginas: 40 - 46

Resumen

Abstract

Salvia officinalis L. (sage) is an important essential oil containing Mediterranean medicinal plant that is commonly cultivated for pharmaceutical uses. In addition to essential oil, other compounds participate on the biological effects of sage, mainly diterpenes, triterpenes and phenolic compounds of the hydroxycinnamic and flavonoid types. Sage essential oil content is known to differ in plant parts, and to be influenced by plant phenophase, climatic and edaphic conditions. This work deals with the study of total hydroxycinnamic derivatives (THD), and specifically rosmarinic acid (RA), content variation in different aerial parts of sage linked to different harvest times. Dry sage leaves (Salviae officinalis folium) THD content was quantified using a pharmacopoeial method, and varied between 3.06 % and 3.52 % in different harvest times, with maxima in youngest plant shoot leaves and newly-grown shoots in September. Sage stems showed similar THD content variations when linked to harvest times, however with lower percentage, 1.33 - 3.04 %. Rosmarinic acid variability showed the same trends, its content ranged between 0.76 % and 1.65 % in leaves, and between 0.19 % and 0.83 % in stems, respectively. Highest percentages of both THD and RA were found in top leaves, lowest in leaves from the middle of the stem. When linked to plant phenophase, the content of THD and RA decreased at flowering time.

Palabras clave

  • Salvia officinalis - THD - rosmarinic acid - plant organ - harvest time

Kľúčové slová

  • Salvia officinalis - THD - kyselina rozmarínová - rastlinná časť - termín zberu

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