Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients
Article Category: Research Article
Published Online: May 04, 2023
Page range: 119 - 124
Received: Jan 12, 2023
Accepted: Mar 07, 2023
DOI: https://doi.org/10.2478/rrlm-2023-0010
Keywords
© 2023 Suat Cakina et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Introduction
In this study, we seek to determine the association between the polymorphism of the
Methods
The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.
Results
Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).
Conclusion
Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.