1. bookVolume 23 (2015): Issue 3 (August 2015)
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
access type Open Access

Diagnostic accuracy of three biomarkers in identifying serious bacterial infections in children younger than 36 months with fever without source / Acurateţea diagnostică a trei biomarkeri în identificarea infecţiilor bacteriene severe la copiii cu vârsta sub 36 luni cu febră fără focar

Published Online: 30 Sep 2015
Page range: 313 - 322
Received: 31 Mar 2015
Accepted: 09 Aug 2015
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English

Objectives: Our study aimed to evaluate and compare the accuracy of C-reactive protein, Procalcitonin and Interleukine-6 in identifying serious bacterial infections (SBI) in children with fever without source.

Keywords

Cuvinte cheie

1. Baraff LJ. Management of infants and young children with fever without source. Pediatr Ann. 2008;37(10):673-9. DOI: 10.3928/00904481-20081001-01Search in Google Scholar

2. Galetto Lacour A, Zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center. Pediatrics. 2003;112(5):1054-60. DOI: 10.1542/peds.112.5.1054Search in Google Scholar

3. Pulliam PN, Attia MW, Cronan KM. C-reactive protein in febrile children 1 to 36 months of age with clinically undetectable serious bacterial infections. Pediatrics. 2001;108(6):1275-9. DOI: 10.1542/peds.108.6.1275Search in Google Scholar

4. Pratt A, Attia MW. Duration of fever and markers of serious bacterial infections in young febrile children. Pediatr Int. 2007;49(1):31-5. DOI: 10.1111/j.1442-200X.2007.02316.xSearch in Google Scholar

5. Hsiao AL, Chen L, Baker MD. Incidence and predictors of serious bacterial infections among 57-to180-daysold infants. Pediatrics. 2006;117(5):1695-701. DOI: 10.1542/peds.2005-1673Search in Google Scholar

6. Maniaci V, Dauber A, Weiss S, Becker KL, Bachur R. Procalcitonin in young febrile infants for the de tectin of serious bacterial infections. Pediatrics. 2008;122(4):701-10. DOI: 10.1542/peds.2007-3503Search in Google Scholar

7. Woelker JU, Sinha M, Christopher NC, Powell KR. Serum procalcitonin concentration in the evaluation of febrile infants 2 to 60 days of age. Pediatr Emerg Care. 2012;28(5):410-5. DOI: 10.1097/PEC. 0b013e318252c474Search in Google Scholar

8. Mahajan P, Grzybrowski M, Chen X, Kannikeswaran N, Stanley R, Singal B, et al. Procalcitonin as a marker of serious bacterial infections in febrile children younger than 3 years old. Acad Emerg Med. 2014;21(2):171-9. DOI: 10.1111/acem.12316Search in Google Scholar

9. Galetto Lacour A, Gervaix A, Zamora SA, Vadas L, Roux Lombard P, Dayer JM, et al. Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identificators of serious bacterial infections in children with fever without localising signs. Eur J Pediatr. 2001;160:95-100. DOI: 10.1007/s004310000681Search in Google Scholar

10. Andreola B, Bressan S, Callegaro S, Liverani A, Plebani M, Da Dalt L. Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department. Pediatr Infect Dis J. 2007;26:672-7. DOI: 10.1097/INF.0b013e31806215e3Search in Google Scholar

11. Olaciregui I, Hernandez U, Munoz JA, Emparanza JI, Landa JJ. Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. Arch Dis Child. 2009 94:501-5. DOI: 10.1136/adc.2008.146530Search in Google Scholar

12. Manzano S, Bailey B, Gervaix A, Cousineau J, Delvin E, Girodias JB. Markers for bacterial infection in children with fever without source. Arch Dis Child. 2011;96:440-6. DOI: 10.1136/adc.2010.203760Search in Google Scholar

13. Gendrel D, Raymond J, Coste J Moulin F, Lorrot M, Guérin S, et al. Comparison of procalcitonin with C-reactive protein, interleukine-6 and interpheron-alpha for differentiation of bacterial vs. viral infections. Pediatr Infect Dis J. 1999;18:875-81. DOI: 10.1097/00006454-199910000-00008Search in Google Scholar

14. Thayyil S, Shenoy M, Hamaluba M, Gupta A, Frater J, Verber IG. Is procalcitonin useful in early diagnosis of serious bacterial infections in children? Acta Pediatrica. 2005;94:155-8. DOI: 10.1080/08035250410025140Search in Google Scholar

15. Galetto-Lacour A, Zamora SA, Gervaix A. A score identifying serious bacterial infections in children with fever without source. Pediatr Infect Dis J. 2008;27:654-6. DOI: 10.1097/INF.0b013e318168d2b4Search in Google Scholar

16. Galetto-Lacour A, Zamora SA, Andreola B, Bressan S, Lacroix L, Da Dalt L et al. Validation of a laboratory index score for the identification of severe bacterial infection in children with fever without source. Arch Dis Child. 2010;95:968-73. DOI: 10.1136/adc.2009.176800Search in Google Scholar

17. Bressan S, Gomez B, Mintegi S, Da Dalt L, Blazquez D, Olaciregui I, et al. Diagnostic performance of the Lab-score in predicting severe and invasive bacterial infections in well-appearing young febrile infants. Pediatr Infect Dis J. 2012;31:1239-44. DOI: 10.1097/ INF.0b013e318266a9aaSearch in Google Scholar

18. Buck C, Bundschu J, Gallati H, Bartmann P, Pohlandt F. Interleukin-6: a sensitive parameter for the early diagnosis of neonatal bacterial infection. Pediatrics. 1994;93:54-8.Search in Google Scholar

19. Küster H, Weiss M, Willeitner AE, Detlefsen S, Jeremias I, Zbojan J, et al. Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation. Lancet. 1998;352(9136):1271-7. DOI: 10.1016/S0140-6736(98)08148-3Search in Google Scholar

20. NICE Clinical Guideline 47. Feverish illness in children: assessment and initial management in children younger than 5 years. National Collaborating Center for Women’s and Child Health; 2007.Search in Google Scholar

21. Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management, Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128(3):595-610. DOI: 10.1542/peds.2011-1330Search in Google Scholar

22. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6. DOI: 10.1097/01. CCM.0000050454.01978.3BSearch in Google Scholar

23. De S, Williams GJ, Hayen A, McCaskill M, Isaacs D, Craig JC. Value of white cell count in predicting serious bacterial infection in febrile children under 5 years of age. Arch Dis Child. 2014;99(6):493-9. DOI: 10.1136/archdischild-2013-304754Search in Google Scholar

24. Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011;342:d3082. DOI: 10.1136/bmj.d3082 Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo