1. bookVolume 23 (2015): Issue 3 (August 2015)
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
access type Open Access

Emergence of Carbapenemase-producing Enterobacteriaceae, a Public Health Threat: a Romanian Infectious Disease Hospital Based Study / Emergenţa Enterobacteriaceaelor producătoare de carbapenemaze, o ameninţare pentru sănătatea publică: un studiu realizat într-un spital romanesc de boli infectioase

Published Online: 30 Sep 2015
Page range: 295 - 301
Received: 12 Mar 2015
Accepted: 26 Jun 2015
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English

Introduction: Hospital-acquired infections caused by Enterobacteriaceae producing different types of carbapenem- hydrolizing enzymes are now commonly observed and represent a great limitation for antimicrobial therapy. The purpose of the study was to evaluate the emergence of carbapenem-resistant Enterobaceriaceae among the strains isolated from hospitalized patients to the National Institute of Infectious Diseases, Bucharest (NIID) and the identification of different types of carbapenemases, using phenotypic methods.

Keywords

1. Gaynes RP, Culver DH, Resistance to imipenem among selected gram-negative bacilli in the United States. Infect Control Hosp Epidemiol. 1992;13:10-4. DOI: 10.2307/30146962 DOI: 10.1086/646417Search in Google Scholar

2. Doumith M, Ellington MJ, Livermore DM, Woodford N. Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother. 2009;63:659-67. DOI: 10.1093/jac/dkp029Search in Google Scholar

3. Naas T, Nordmann P. Analysis of carbapenem-hydrolyzing class A β-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein. Proc Natl Acad Sci U S A. 1994;91:7693-7. DOI: 10.1073/ pnas.91.16.7693Search in Google Scholar

4. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase- producing Enterobacteriaceae. Emerg Infect Dis. 2011;17:1791-8. DOI: 10.3201/eid1710.110655Search in Google Scholar

5. Giske CG, Martinez-Martinez L, Cantón R, Stefani S, Skov R, Glupczynski Y et al. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. 2013. Version 1.0:4-10.Search in Google Scholar

6. Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez A, Pollini S, et al. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill. 2014;19(42):pii=20939. DOI: 10.2807/1560-7917.es2014.19.42.20939Search in Google Scholar

7. Poirel L, Héritier C, Tolün V, Nordmann P. Emergence of oxacillinase-mediated reistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004;48(1):15-22. DOI: 10.1128/AAC.48.1.15-22.2004Search in Google Scholar

8. Glasner C, Albiger B, Buist G, Tambić Andraśević A, Canton R, Carmeli Y, et al. The European Survey on Carbapenemase-Producing Enterobacteriaceae (Eu- SCAPE) working group. Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries, February 2013. Euro Surveill. 2013;18(28):pii=20525.Search in Google Scholar

9. Djahmi N, Dunyach-Remy C, Pantel A, Dekhil M, Sotto A, Lavigne JP. Epidemiology of carbapenemase-producing Enterobaceriaceae and Acinetobacter baumannii in Mediterranean Countries. BioMed Research International. 2014. Article ID 305784, 11 pages.Search in Google Scholar

10. Pavelkovich A, Balode A, Edquist P, Egorova S, Ivanova M, Kaftyreva L, et al. Detection of carbapenemase- producing Enterobacteriaceae in the Baltic countries and St. Petersburg area. BioMed Research International. 2014. Article ID 548960, 7 pages.Search in Google Scholar

11. European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2013. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2014.Search in Google Scholar

12. Székely E, Damjanova I, Jánvári L, Vas KE, Molnár S, Bilca DV, et al. First description of blaNDM-1, bla- OXA-48, blaOXA-181 producing Enterobacteriaceae strains in Romania. Int J Med Microbiol. 2013;303:697-700. DOI: 10.1016/j.ijmm.2013.10.001Search in Google Scholar

13. Mirioagou V, Tzelepi E, Kotsakis SD, Daikos GL, Bou Casals J, Tzouvelekis LS. Combined disk methods for the detection of KPC- and/or VIM-positive Klebsiella pneumoniae: improving reliability for the double carbapenemase producers. Clin Microbiol Infect. 2013;19:412-5. DOI: 10.1111/1469-0691.12238Search in Google Scholar

14. Tzouvelekis LS, Markogiannakis A, Piperaki E, Souli M, Daikos GL. Treating infections caused by carbapenemase- producing Enterobacteriaceae. Clin Microbiol Infect. 2014;20:862-872. DOI: 10.1111/1469-0691.12697Search in Google Scholar

15. Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez F, Pollini S, et al. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill. 2014; 19(42):pii=20939. DOI: 10.2807/1560-7917.es2014.19.42.20939Search in Google Scholar

16. Woodford N, Eastaway AT, Ford M, Leanord A, Keane C, Quayle RM, et al. Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. J Clin Microbiol. 2010. 48(8):2999-3002. DOI: 10.1128/JCM.00341-10 Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo