1. bookVolume 61 (2010): Issue 1 (March 2010)
Zeitschriftendaten
License
Format
Zeitschrift
Erstveröffentlichung
26 Mar 2007
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch
access type Open Access

Allergotoxicology: Research of Pollutant Influence on the Development of Allergic Reactions

Online veröffentlicht: 25 Mar 2010
Seitenbereich: 85 - 94
Zeitschriftendaten
License
Format
Zeitschrift
Erstveröffentlichung
26 Mar 2007
Erscheinungsweise
4 Hefte pro Jahr
Sprachen
Englisch

Alergotoksikologija je znanstvenoistraživačko područje koje se bavi ispitivanjem utjecaja polutanata (onečišćivača zraka) na nastanak alergijskih reakcija i bolesti. Ispitivanja su prvobitno bila usmjerena na polutante vanjskih prostora, a u novije vrijeme sve više na polutante unutarnjih prostora u kojima ljudi provode većinu vremena. Polutanti po svojoj prirodi mogu biti krute, tekuće ili plinovite čestice, koje se razlikuju s obzirom na veličinu, sastav i izvor iz kojeg nastaju. S obzirom na izvor mogu biti biološkog i nebiološkog podrijetla. Polutanti koji su predmet suvremenih istraživanja s gledišta nastanka alergijskih bolesti su respirabilne krute čestice, ozon, dušični oksidi i bioaerosoli. Mehanizam djelovanja polutanata ovisi o veličini čestica, njihovoj topljivosti i mjestu ulaska u organizam. Dosadašnja ispitivanja su pokazala da različite čestice uvjetuju različite imunosne i neimunosne odgovore u organizmu. Interakcija polutanata i alergena može se zbivati izvan eksponirane osobe, tj. sa samim alergenom ili u eksponiranoj osobi na sluznicama i koži. Polutanti mogu biti nosioci alergena i mogu interferirati na različitim nivoima u nastanku alergijske reakcije. U ovom prikazu razmatraju se dosadašnja saznanja o mehanizmima djelovanja polutanata na alergene, na imunosni sustav izloženih osoba na osnovi epidemioloških populacijskih istraživanja, kliničkih studija ekspozcije u kontroliranim uvjetima i eksperimentalnih testnih sistema in vivo i in vitro.

Behrendt H, Krämer U, Schäfer T, Kasche A, Eberlein-Köning B, Darsow U, Ring J. Allergotoxicology - a research concept to study the role of environmental pollutants in allergy. Allergy Clin Immunol Int 2001;13:122-8.Search in Google Scholar

Chen B, Kan H. Air pollution and population health: a global challenge. Environ Health Prev Med 2008;13:94-101.Search in Google Scholar

Behrendt H, Friedrichs K, Krämer U. The role of indoor and outdoor air pollution in allergic diseases. U: Johansson S, urednik. Progress in allergy and clinical immunology. Seattle: Hogrefe & Huber; 1995. str. 83-9.Search in Google Scholar

Ring J. Allergy and modern society: does "Western life style" promote the development of allergies? Int Arch Allergy Immunol 1997;113:7-10.Search in Google Scholar

Wahn U. What drives the allergic march? Allergy 2000;55:591-9.Search in Google Scholar

Strannegård Ö, Strannegård I-L. The causes of the increasing prevalence of allergy: is atopy a microbial deprivation disorder? Allergy 2001;56:91-102.Search in Google Scholar

Wright RJ, Weiss ST. Epidemiology of allergic diseases. U: Holgate ST, Church MK, Lichenstein LM, urednici. Allergy. 2. izd. London (UK): Mosby International Ltd.; 2001. str. 203-12.Search in Google Scholar

Cruz AA, Popov T, Pawankar R, Annesi- Maesano I, Fokkens W, Kemp J, Ohta K, Price D, Bousquet J. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA2LEN. Allergy 2007;62(Suppl 84):1-41.Search in Google Scholar

Mösges R, Klimek L. Today's allergic rhinitis patients are different: new factors that may play role. Allergy 2007;62:969-75.Search in Google Scholar

Björkstén B, Kjellman BN-IM, Zeiger RS. Development and Prevention of AllergicDisease in Childhood. U: Middleton E Jr, Reed CE, Ellis EE, Adkinson NF Jr, Yunginger JW, Busse WW, urednici. Allergy - Principles and practice. 5. izd. St Louis (MO): CV Mosby; 1998. str. 816-37.Search in Google Scholar

Hoffmann D, Wynder EL. Indoor air quality: Tobacco smoke. U: Stellman JA, urednik. Encyclopedia of occupational health and safety. 4. izd. Vol 1. Ženeva: ILO; 1998. str. 44.11-4.Search in Google Scholar

Flannigan B. Indoor air quality: Biological contamination. U: Stellman JA, urednik. Encyclopedia of occupational health and safety. 4. izd. Vol 1. Ženeva: ILO; 1998. str. 44.21-26.Search in Google Scholar

World Health Organization (WHO). Indoor air quality: biological contaminants. WHO Regional Publications, European Series, No. 31. Copenhagen: WHO Regional Office for Europe; 1990. str. 1-67.Search in Google Scholar

WHO Air quality guideline for particulate matter, ozone, nitrogen, dioxide and sulfur dioxide. Global update 2005. Summary of risk assessment [displayed 2 February 2010]. Available at: http://whqlibdoc.who.int/hq/2006/WHO_SDE_PHE_OEH_06.02_eng.pdfSearch in Google Scholar

Kunkel G, Schierhorn K. Air pollution and allergic and nonallergic airway disease. Allergy Clin Immunol Int 1999;11:82-5.Search in Google Scholar

Eigenmann PA. Diagnosis of allergy syndromes: do symptoms always mean allergy? Allergy 2005;60(Suppl 79):6-9.Search in Google Scholar

Ćustović A, Murray C, Simpson A. Allergy and infection: understanding their relationship. Allergy 2005;60(Suppl 79):10-3.Search in Google Scholar

Bacharier LB, Boner A, Carisen KH, Eigenmann PA, Frischer T, Götz M, Helms PJ, Hunt J, Liu A, Papadopoulos N, Plattts-Mills T, Pohunek P, Simons FER, Valovirta E, Wahn U, Wildhaber J. The European Pediatric Asthma Group. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008;63:5-34.Search in Google Scholar

Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005;60:1357-60.Search in Google Scholar

Kilpeläinen M, Koskenvou M, Helenius H, Terho EO. Stressful life events promote the manifestation of asthma and atopic diseases. Clin Exp Allergy 2002;32:256-63.Search in Google Scholar

Pruett SB. Stress and the immune system. Patophysiol 2003;9:133-53.Search in Google Scholar

Kanceljak-Macan B, Macan J, Plavec D, Milković-Kraus S, Žuškin E. Alergijski poremećaji dišnog sustava i kože kao javno zdravstveni problem. Liječ Vjesn 2003;125:81-7.Search in Google Scholar

Radošević-Vidaček B, Macan J, Košćec A. Stres i alergija. Arh Hig Rada Toksikol 2004;55:205-11.Search in Google Scholar

Thompson PJ, Stewart GA, Samet JM. Allergens and pollutants. U: Holgate ST, Church MK, Lichenstein LM, urednici. Allergy. 2. izd. London: Mosby International Ltd.; 2001. str. 213-42.Search in Google Scholar

Pope CA. Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk? Environ Health Persp 2000;108(Suppl 4):713-23.Search in Google Scholar

Leslie GB. Health risk from indor air pollutants: public alarm and toxicological reality. Indoor Built Environ 2000;9:5-16.Search in Google Scholar

Burge HB. Bioaerosols: Prevalence and health effects in the indoor environment. J Allergy Clin Immunol 1990;86:687-701.Search in Google Scholar

Gomzi M. Unutrašnji prostor i zdravlje. Sigurnost 2000;42:257-65.Search in Google Scholar

Rylander R, Schilling RSF. Diseases caused by organic dust. U: Stellman JA, urednik. Encyclopedia of occupational health and safety. 4. izd. Vol 1. Ženeva: ILO; 1998. str. 10.24-7.Search in Google Scholar

Žuškin E, Mustajbegović J, Kern J, Ivanković D, Kanceljak B. Učinci organskih aersola na dišni sustav profesionalno izloženih osoba. Liječ Vjesn 2003;125:151-6.Search in Google Scholar

Kanceljak-Macan B, Žuškin E, Macan J. Organic aerosols and the development of allergic disorders. Arh Hig Rada Toksikol 2004;55:213-20.Search in Google Scholar

Brunekreef B, Holgate ST. Air pollution and health. Lancet 2002;360:1233-42.Search in Google Scholar

von Mutius E, Fritzsch C, Weiland S, Röll G, Magnussen H. Prevalence of asthma and allergic disorders among children in united Germany: A descriptive comparison. Br Med J 1992;305:1395-9.Search in Google Scholar

Trepka MJ, Heinrich J, Wichmann HE. The epidemiology of atopic diseases in Germany: an East-West comparison. Rev Environ Health 1996;11:119-31.Search in Google Scholar

D'Amato G. Airborne paucimicronic allergen-carring particles and seasonal respiratory allergy. Allergy 2001;56:1109-1111.Search in Google Scholar

Bartra J, Mullol J, del Cuvillo A, Dávila I, Ferrer M, Jáuregui I, Montoro J, Sastre J, Valero A. Air pollution and allergens. J Investig Alergol Clin Immunol 2007;17(Suppl 2):3-8.Search in Google Scholar

D'Amato G, Liccardi G, D'Amato M, Cazzola M. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Resp J 2002;20:763-76.Search in Google Scholar

Koistinen K, Kotzias D, Kephalopoulos S, Schlitt C, Carrer P, Jantunen M, Kirchner S, McLaughlin J, Mølhave L, Fernandes EO, Seifert B. The INDEX project:executive summary of a European Union project on indoor air pollutants. Allergy 2008;63:810-9.Search in Google Scholar

Salvaggio JE, Lehrer SB, Stankus RP. Smoking and allergy. U: Pichler WJ, Stadier BM, Dahinden CA, Pecoud AR, Frei P, Schneider CH, de Weck Al, urednici. Progress in allergy and clinical immunology. Toronto (CA): Hogrefe & Huber Publishers; 1989. str. 259-6.Search in Google Scholar

Paoletti P, Baldacci S, Simoni M, Biavati P, Carrozzi L, Pedreschi M, Modena P, Vellutini M, Diviggiano E, Ballerin L, Viegi G, Sapigni Z, Giuntini C. Tobacco smoking and allergy. U: Godard PH, Bousquet J, Michel FB, urednici. Advances in allergology and clinical immunology. Carnforth (UK): Parthenon Publishing Group Ltd.; 1992. str. 349-58.Search in Google Scholar

Björksten B. Risk factors in early childhood for the development of atopic diseases. Allergy 1994;49:400-7.Search in Google Scholar

Reed CE, Milton DK. Endotoxin-stimulated innate immunity a contributing factor for asthma. J Allergy Clin Immunol 2001;108: 157-66.Search in Google Scholar

Varnai VM, Macan J, Plavec D, Jureša D. Endotoxin measurement in house dust using the end-point Limulus amoebocyte lysate method. Arh Hig Rada Toksikol 2004;55:175-81.Search in Google Scholar

Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154:1641-6.Search in Google Scholar

Kanceljak-Macan B, Macan J, Plavec D. Alergeni vanjskih i unutarnjih prostora i dišni sustav. Arh Hig Rada Toksikol 2000;51:321-33.Search in Google Scholar

Motta AC, Marliere M, Peltre G, Sterenberg PA, Lacroix G. Traffic-related air pollutants induce the release of allergencontaining cytoplasmic granules from grass pollen. Int Arch Allergy Immunol 2006;139:294-8.Search in Google Scholar

D'Amato G, Cecchi L, Bonini S, Nunes C, Annesi-Maesano I, Behrendt H, Liccardi G, Popov T, van Cauwenberge P. Allergen pollen and pollen allergy in Europe. Allergy 2007;62:976-90.Search in Google Scholar

Vos JG, von Loveren H. Immunotoxicology. U: Stellman JA, urednik. Encyclopedia of occupational health and safety. 4. izd. Vol 1. Ženeva: ILO; 1998. str. 33.35-9.Search in Google Scholar

Dekaris D, Rabatić S. Imunologija. U: Vrhovac B, urednik. Interna medicina. 3. izd. Zagreb: Naklada Ljevak d.o.o.; 2003. str. 53-67.Search in Google Scholar

Holgate S. 18th Meeting of the Collegium Internationale Allergologicum, Madeira 1990. Allergy Today 1991;4(1):12-14.Search in Google Scholar

Kanceljak-Macan B. Suvremeni pogledi na alergijske bolesti. Arh Hig Rada Toksikol 2004;55:123-34.Search in Google Scholar

Smith Pease CK. From xenobiotic chemistry and metabolism to better prediction and risk assesment of skin allergy. Toxicology 2003;192:1-22.Search in Google Scholar

Gerber BO, Pichler WJ. Cellular mechanisms of T cell mediated drug hypersensitivity. Curr Opin Immunol 2004;16:732-7.Search in Google Scholar

Ishizaki T, Koizumi K, Ikemori R, Ishiyama Y, Kushibiki E. Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy 1987;58:265-70.Search in Google Scholar

Brito FF, Gimeno PM, Martinez C, Tobias A, Suárez L, Guerra F, Borja JM, Alonso AM. Air pollution and seasonal asthma during the pollen season. A cohort study in Puertollano and Cindad Real (Spain). Allergy 2007;62:1152-7.Search in Google Scholar

Janssen NAH, Brunekreef B, van Vliet P, Aarts F, Meliefste K, Harssema H, Fischer P. The relationship between air pollution from haevy traffic and allergic sensitisation, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ Health Perspect 2003;111:1512-8.Search in Google Scholar

Jögi R, Jansson C, Björnsson E, Boman G, Björksten B. The prevalence of asthmatic respiratory symptoms among adults in an Estonian and Swedish universury town. Allergy 1996;51:331-6.Search in Google Scholar

Macan J, Kanceljak-Macan B, Mustač M, Milković-Kraus S. Analysis of dust samples from urban and rural occupational environments in Croatia. Arh Hig Rada Toksikol 2005;56:327-32.Search in Google Scholar

Banac S, Tomulić KL, Ahel V, Rozmanić V, Šimundić N, Zubović S, Milardović A, Topić J. Prevalence of asthma and allergic diseases in Croatian children is increasing: survay study. Croat Med J 2004;45:721-6.Search in Google Scholar

Diaz-Sanches D, Tsien A, Casillas A, Dotson AR, Saxon A. Enhanced nasal cytokine production in humans following in vivo challlenge with diesel exhaust particles. J Allergy Clin Immunol 1996;98:114-9.Search in Google Scholar

Diaz-Sanches D, Tsien A, Fleming J, Saxon A. Combined disel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol 1997;158:2406-13.Search in Google Scholar

van Och FMM, Vandebriel RJ, De Jong WH, van Loveren H. Effect of prolonged exposure to low antigen concentration for sensitization. Toxicology 2003;184:23-30.Search in Google Scholar

van den Berg FA, Baken KA, Vermeulen JP, Gremmer ER, van Steeg H, van Loveren H. Use of the local lymph node assay in assesment of immune function. Toxicology 205;211:107-14.Search in Google Scholar

Vandebriel RJ, De Jong WH, Spiekstra SW, van Dijk M, Fluitman A, Garssen J, van Loveren H. Assesment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compaunds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-Y and interleukin-4. Toxicol Appl Pharmacol 2000;162:77-85.Search in Google Scholar

Løvik M, Alberg T, Nygaard UC, Samuelsen M, Groeng EC, Gaarder PI. Popliteal lymph node (PLN) assay to study adjuvant effects on respiratory allergy. Methods 2007;41:72-9.Search in Google Scholar

Dybing E, Løvdal T, Hetland RB, Løvik M, Schwarze PE. Respiratory allergy adjuvant and inflammatory affects of urban ambient particles. Toxicology 2004;198:307-14.Search in Google Scholar

Ormstad H, Groeng E-C, Duffort O, Løvik M. The effect of endotoksin on the production of IgE, IgG1 and IgG2a antibodies against the cat allergen Fel d 1 in mice. Toxicology 2003;188:309-18.Search in Google Scholar

MacKay C, Bajaria S, Shaver G, Kudrycki K, Ramanujan S, Peterso T, Friedrich C, Maxwell G, Jowsey I, Lockley D, Reynolds F, Fentem J. In silico modelling of skin sensitization. Toxicology 2007;231:103.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo