rss_2.0Medicine FeedSciendo RSS Feed for Medicinehttps://www.sciendo.com/subject/MDhttps://www.sciendo.comMedicine Feedhttps://www.sciendo.com/subjectImages/Medicine.jpg700700Associations between differing magnitudes of inter-limb asymmetry and linear and change of direction speed performance in male youth soccer playershttps://sciendo.com/article/10.2478/bhk-2022-0009<abstract> <title style='display:none'>Abstract</title> <p><italic>Study aim</italic>: This study examines the relationship between different magnitudes of asymmetry and their effects on speed performance.</p> <p><italic>Material and methods</italic>: Forty-two sub-elite male youth soccer players performed a 30-m sprint, change of direction, single leg countermovement jump and single leg hop. Subjects were divided into groups with vertical and horizontal asymmetry, and both groups were then divided into three groups according to magnitudes of inter-limb asymmetry (&lt;5%, 5–10%, and &gt;10%).</p> <p><italic>Results</italic>: The results showed no significant correlation between different jump asymmetry magnitudes and the mentioned outcomes of speed performance (p &gt; 0.05). In addition, larger asymmetries resulted in faster linear speed, even if small differences (g range = 0.00 to 0.57; p &gt; 0.05). But this was not similar for change of direction speed (g range = –0.42 to 0.34; p &gt; 0.05).</p> <p><italic>Conclusions</italic>: There are inconsistent findings for the effects of inter-limb asymmetries on speed performance. The results of the present study indicate that the magnitude of asymmetry had no meaningful association with independent measures of performance in soccer players. Therefore, it seems more likely to explain the effects of individual asymmetries on performance rather than the idea that asymmetry negatively affects performance.</p> </abstract>ARTICLE2022-01-28T00:00:00.000+00:00COVID-19 Pandemic: A Survey of Safety Practices among Eye Care Workers in Nigeriahttps://sciendo.com/article/10.2478/aphi-2022-0001<abstract> <title style='display:none'>Abstract</title> <p>Objective: To assess safety practices among eye care workers in Nigeria during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This research was a cross-sectional study. A structured electronic questionnaire was distributed among eye care workers (ophthalmologists, optometrists, ophthalmic nurses) across the six geographical zones of Nigeria. Information on socio-demographics, COVID-19 infection, current working conditions and safety practices were obtained. Data analysis was done using Statistical Package for Social Sciences (SPSS Inc. Chicago Illinois, USA) for windows, version 22. Results: A total of 236 eye care workers participated in the study; their mean (±SD) age was 37.13 (±8.141) years, 125 (53%) were females, and 145 (61.4%) worked in a tertiary care hospital. All participants described COVID-19 as a viral disease and 98.3% agreed that the disease can affect the eyes. Outpatient clinic consultation was recorded as the highest (77.7%) service provided during the pandemic. Regarding preventive practices, 95% of eye care workers wore facemasks, 82.4% wore gloves during ophthalmic examination and Hazmat suit was the least used protective device (2.5%). About three-quarters (77.5%) reported feeling unsafe in their working environment and 63.9% were dissatisfied with the personal protective device provided by hospitals to eye care workers. Conclusion: COVID-19 pandemic presented an unprecedented challenge for eye care workers; with the practice of ophthalmology posing a high risk of transmission of the virus. Efforts should be made to provide the required personal protective devices needed for optimum protection of eye care workers in healthcare settings.</p> </abstract>ARTICLE2022-01-28T00:00:00.000+00:00Immunohemtatologyhttps://sciendo.com/journal/IMMUNOHEMATOLOGY<P>As a highly respected journal with an international readership, <EM>Immunohematology, Journal of Blood Group Serology and Molecular Genetics</EM> is published quarterly (March, June, September, and December) by The American National Red Cross.The journal is subscription based and peer reviewed and brings together research and clinical practice from well-known experts in the field of blood group serology and molecular immunogenetics. </P> <P><STRONG>Aim and Scope</STRONG> </P> <P>Immunohematology, Journal of Blood Group Serology and Molecular Genetics publishes case reports, original scientific reports, conference reports, book reviews, editorial commentaries, and review articles covering the spectrum of clinical and laboratory practice and research in the field of laboratory medicine. The journal welcomes manuscripts on red cell, white cell, and platelet serology as well as original scientific investigations of new blood group alleles, molecular testing platforms, and new methods for use in the blood bank. Immunohematlogy cases that illustrate a sound investigative approach with clinical correlation, reflecting appropriate collaboration to sharpen problem-solving skills can be submitted as an educational forum. </P> <P><STRONG>Open Access</STRONG> </P> <P>One article per published issue is available in open access format for all readers. Identification of this article is noted in 'Recently published' section. </P> <P><STRONG>Peer Review Process</STRONG> </P> <P>Manuscripts submitted for publication in <EM>Immunohematology, Journal of Blood Group Serology and Molecular Genetics</EM> are peer reviewed by selected experts in the medical and technical field of transfusion medicine and/or immunohematology. Each peer reviewer assesses the manuscript for the novelty of the information, the quality and completeness of the provided scientific and clinical data, the quality and appropriateness of the tables and figures, the overall clarity of presentation of the information, and the interest of this topic to the readers of this journal. In addition, each reviewer determines if additional statistical review is needed and if the references are current and appropriate. </P> <P>Peer reviewers provide a final assessment to accept or reject the manuscript outright, or revise the manuscript. If revision is determined, the peer reviewer provides specific comments to improve the quality of the manuscript. The reviewers’ comments are compiled and reviewed by the overseeing editor who provides additional comments, if appropriate. All comments are then sent to the authors for reply and revision, if applicable. </P> <P>The authors’ reply and revised manuscript are reviewed by the overseeing editor and acceptance/rejection of the manuscript is determined. </P> <P>Confidentiality of all peer reviewers is respected. </P> <P>Rejection rate: 25% </P> <P><STRONG>Subscription</STRONG> <STRONG>Rates</STRONG> </P> <P>Annual Subscription Rates for 2022: </P> <P>Individual Online Only: $75<BR>Individual US Online and Print: $150<BR>Individual Non-US Online and Print: $200<BR>SBB Student Online Only: $0 Gratis with validation of SBB program enrollment<BR>Institution Online Only: $350<BR>Institution US Online and Print: $600<BR>Institution Non-US Online and Print: $800<BR>For printed copies only, send email request to <A href="mailto:immuno@redcross.org">immuno@redcross.org</A> </P> <P><STRONG>ABOUT SOCIETY</STRONG> </P> <P>With a focus on better patient outcomes through shared expertise and designed for physicians and laboratory professionals in the areas of blood banking and transfusion medicine, <A href="https://www.redcrossblood.org/biomedical-services/educational-resources/educational-resources.html">SUCCESS®</A> is a comprehensive suite of educational resources comprised of online instruction, industry publications, and learning events. In support of <A href="https://www.redcrossblood.org/biomedical-services/educational-resources/educational-resources.html">SUCCESS®</A>, the American National Red Cross publishes Immunohematology, Journal of Blood Group Serology and Molecular Genetics on a quarterly basis with a focus on original research, invited reviews, case reports, and new allele publications. </P> <P><STRONG>Archiving</STRONG> </P> <P>Sciendo archives the contents of this journal in <A href="https://www.portico.org/">Portico</A> - digital long-term preservation service of scholarly books, journals and collections. </P> <P><STRONG>Plagiarism Policy</STRONG> </P> <P>The editorial board is participating in a growing community of <A href="https://www.crossref.org/services/similarity-check/">Similarity Check System's</A> users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process.</P> JOURNAL2022-06-30T00:00:00.000+00:00Misdiagnosis of pulmonary artery aneurysm with eroding thrombus into the airways. A fatal case of suffocationhttps://sciendo.com/article/10.2478/sjfs-2021-0001<abstract> <title style='display:none'>Abstract</title> <p>We present a fatal case of hemoptysis following a thrombus-eroding pulmonary artery aneurysm into the left upper bronchus of a 79-year-old male with a history of multiple hospital contacts and examinations due to cough, hemoptysis, and reflux symptoms.</p> <p>A postmortem computed tomography (CT) scan revealed a hyperdense, condensed area in the left lung in relation to the lung hilus. At autopsy, the forensic specialist discovered a large, organized thrombus in a pulmonary artery aneurysm. The thrombus was adherent to the pulmonary artery aneurysm wall with an underlying defect directly communicating to the left upper bronchus. The cause of death was asphyxia due to blood in the airways (i.e., suffocation).</p> <p>The combination of pulmonary artery hypertension, previous pulmonary embolism, and hemoptysis should lead to a particularly thorough inspection of the lungs with a focus on the pulmonary circulation. This case report emphasizes the importance of early detection of patients at risk of pulmonary artery rupture and attentiveness when performing biopsies during bronchoscopy to prevent communication between the artery and the airway. The risk of rupturing an aneurysm should be taken into account when performing biopsies on excrescence intruding into the bronchus in patients with medical histories of pulmonary hypertension, cough, and sporadic hemoptysis.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Peculiar encounter of sarcoidosis and solid pseudopapillary tumor of the pancreashttps://sciendo.com/article/10.2478/rjim-2022-0001<abstract> <title style='display:none'>Abstract</title> <sec><title style='display:none'>Objective</title> <p>Current literature indicates a connection between sarcoidosis and malignancy, prompting advanced screening in uncertain cases. Solid pseudopapillary tumors (SPT) of the pancreas are rare entities that can be confirmed by adding imaging results to immunohistochemistry staining. The aim of this article is to describe a rare association of sarcoidosis and SPT.</p> </sec> <sec><title style='display:none'>Materials and methods</title> <p>Case report.</p> </sec> <sec><title style='display:none'>Results</title> <p>A young female patient with no prior medical history presents with shortness of breath and fatigue. The diagnosis of pulmonary and hepatic sarcoidosis is placed upon laboratory and radiographic changes. Intermittent abdominal pain prompts an MRI that shows the presence of a tumoral mass in the tail of the pancreas. Surgical resection of the mass is performed and histological examination indicates a SPT, subsequently confirmed by immunohistochemistry.</p> </sec> <sec><title style='display:none'>Conclusion</title> <p>This is the third reported case of concomitant sarcoidosis and solid pseudopapillary tumor of the pancreas.</p> </sec> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00New trend in transfusion medicine – Patient blood managementhttps://sciendo.com/article/10.2478/orvtudert-2021-0002<abstract> <title style='display:none'>Abstract</title> <p>Transfusion is often part of hospital care, the indication being in constant change as an effect of latest multicentric studies’ result. Although transfusion-related complications decreased significantly, the intervention still involves risks, that are worth assuming if only the anemia of patient cannot be managed with other, safer methods. Management of patients declining transfusion or of those unsuitable for transfusion has brought instructive results in assessment of hemoglobin concentration conditioning the necessity of the intervention. Further development of these findings led to development of Patient Blood Management concept, aiming the optimization of blood product usage while improving morbidity and mortality of patient care. Patient Blood Management applies guides helping to avoid transfusions that are not definitely necessary for patients. Using restrictive transfusion principles, preoperative anemia management, tight hemostasis monitoring and treatment, is not only safer but also cost-effective. The objective of our paper is the brief report of some Patient Blood Management guidelines, and to promote and facilitate the application of the new approach.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Marfan syndrome associated with type 1 diabetes and autoimmune thyroiditis in a 27 years old female patient - Case presentationhttps://sciendo.com/article/10.2478/orvtudert-2021-0001<abstract> <title style='display:none'>Abstract</title> <p>Introduction: Marfan syndrome (MFS) is a genetically determined connective tissue disorder caused by a mutation in the FBN1 gene, located on chromosome 1, which regulates the production of the glycoprotein Fibrillin 1. This results in different connective tissue diseases, especially cardiovascular involvement. Objective: The aim of our presentation is the description of a case in which type 1 autoimmune diabetes and thyreoiditis coexists in a previously undiagnosed patient with MFS. Case presentation: A 27-years-old female patient presented to the emergency department with a 6 months long polyuria-polydipsia syndrome, with weight loss of -10kg. The onset of diabetes manifested with severe ketoacidosis (blood glucose=674 mg/dl, pH=7,036, urinary ketone bodies=159 mg/dl). Pathological laboratory findings include C-peptide=212 ng/ml, anti glutamic acid decarboxylase (GAD) = 5,1UI/ml, ATPO=558 UI/ml. Clinical features of MFS could be recognised, like dolicocephalic face with enophthalmus, height: 184 cm, weight: 40 kg with a BMI of 11,81 kg/m2 respectively 50 kg and 14,77 kg/m2 before weight loss; long limbs, arachnodactyly, kyphoscoliosis, mitral systolic murmur. Imaging procedures showed atrial septal defect with a 6 mm bidirectional shunt, the ascending aorta, the trunk and the aortic isthmus were dilated, mitral valve prolapse, tricuspid valve insufficiency and dilatation of the right heart cavities, interatrial septal aneurysm and pulmonary hypertension. The ECG showed a right branch block. Ophthalmologic examination confirms the lens subluxation. Discussion: The etiology of diabetes and thyroiditis has proven to be autoimmune. With the introduction of base-bolus insulin therapy glycemic control was obtained and beta-blocker treatment was started for the cardiac involvement. Summary: This particular case is unique due to the fact that associates two serious lifelong diseases. MFS should be considered on the basis of morphological characteristics, which requires further investigation due to its serious long term complications.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00The 150th anniversary of the Hungarian Pharmacopoiea – the role of Transsylvanian-born professionals. The challenges of the third millenniumhttps://sciendo.com/article/10.2478/orvtudert-2021-0005<abstract> <title style='display:none'>Abstract</title> <p>Two editions of the epoch-making first Hungarian pharmacopoeia (1871, 1888) were published in the 19th century. In the 20th century, this was followed by five more editions of the National Pharmacopoeia.</p> <p>There were many prominent Transylvanian specialists among the co-workers of these publications (III. - VII., 1909-1986) Lajos Dávid, senior dr. Béla Issekutz, dr.Zsigmond Jakabházy, junior dr. Miklós Jancsó, László Kovács, Dénes Kőszegi, István Novák, Tibor Széki, Lajos Winkler representing almost all fields of pharmacology and pharmacy. Their role in the field of Hungarian medical and pharmacist training, education and organization of scientific research proved to be perpetual.</p> <p>On the 150th anniversary of the publication of the first Hungarian pharmacopoeia, with this study we pay tribute to the memory of these outstanding scientists and their endeavour to create lasting values.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Analysis of psycho-sociodemographic features in referred male psychiatric patients with suicidal ideationhttps://sciendo.com/article/10.2478/orvtudert-2021-0003<abstract> <title style='display:none'>Abstract</title> <p>Suicide is defined by the World Health Organization as an act in which an individual ends his or her own life. Suicidal behavior is a major public health problem worldwide. According to the World Health Organization, the global suicide rate is 10,5/100.000 – 13,5/100.000 in case of men and 7,7/100 000 in case of women and is the 2nd most common cause of violent death. Suicide is a multifactorial phenomenon that can be approached from different perspectives. In Romania, this rate is similar to the global rate: in 2016, the estimated suicide rate was 10.4/100,000, well below the European average. Suicide rates vary by region, age group, gender, ethnicity, and registration of mortality statistics. The aim of the present study is to investigate the psycho-socio-demographic indicators of a cohort of patients with suicidal thoughts emergency referred to a particular psychiatric ward in one year. In our research, we performed a case-control, analytical, randomized, observational study at the Clinical Hospital of Neurology and Psychiatry Brasov among adult psychiatric patients admitted during 2014. The following data on patients were processed: demographic data (age, gender, place of residence), psychosocial data (social background, marital status, education), chronic somatic comorbidities, family history of psychiatric illness, pre-existing psychiatric illnesses, previous suicide attempts and their characteristics. The risk of suicide was assessed by the Modified Scale for Suicide Ideation - Miller et al. Questionnaire and distinguished 3 categories. In our sample of 77 cases we identified 14 patients with low suicide risk, 17 with moderate risk and 46 with high suicide risk. The focus of our study was on suicidal behavior. Suicide attempt, as a complex clinical problem with a waste complexity of ethiology, has high demands on psychiatric care. Being familiar with the different psycho-socio-demographic profiles by gender is proved to be a useful tool in both “screening” and in subsequent case management. These principles can facilitate decision-making, can increase adherence to treatment, and reduce the risk of repetitive attempts.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Comments on the Hungarian pharmacopoeias in the 19th centuryhttps://sciendo.com/article/10.2478/orvtudert-2021-0004<abstract> <title style='display:none'>Abstract</title> <p>Before 150 years the first Hungarian pharmacopoeia was compiled in 1871 as a result of nearly one century of national efforts. The first four editions were published in two languages, Hungarian and Latin. The second edition (1888) became better than the first one showing significant progress mainly in terms of speciality language.</p> <p>Based on the first edition Prof. Kálmán Balogh, medical doctor, published an encyclopaedic commentary, which is an unparalleled source-work of the contemporary Hungarian pharmacological literature.</p> <p>Geyza Karlovszky and Lajos Winkler issued a pocket edition (“Pocket Commentary”) based on the chemistry articles of the second edition of the pharmacopoeia, which became an important practical handbook of pharmacist education.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Cystic Echinococcosis in Slaughtered Cattle and Sheep from North Macedoniahttps://sciendo.com/article/10.2478/macvetrev-2022-0011<abstract> <title style='display:none'>Abstract</title> <p>Cystic echinococcosis is a cosmopolitan zoonotic infection, commonly seen in areas where livestock and dogs are kept together. The objective of this study was to investigate the prevalence of echinococcosis in slaughtered cattle and sheep in North Macedonia and to evaluate the location and fertility/sterility rates of the cysts. A total of 302 slaughtered animals were examined with visual inspection, palpation, and incision of the internal organs in order to detect cysts. Microscopic examination was carried out to determine the presence of protoscoleces. The overall prevalence of echinococcosis in slaughtered cattle and sheep was 60%. The presence of cysts increased with age in cattle. In both cattle and sheep, the most common affected organs were the liver and lungs infected with more than one cyst. The findings showed higher fertility rate in sheep which confirmed their role as the most important intermediate host. This study shows that North Macedonia is an endemic region, and serious control strategies should be implemented, with special emphasis on safety disposal of infected organs and anthelmintic treatment of the dogs.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Detection of Enterotoxigenic Potential of Isolates from Cheese Samples with Two Different Methodshttps://sciendo.com/article/10.2478/macvetrev-2022-0010<abstract> <title style='display:none'>Abstract</title> <p>The primary objective of our study was to detect the occurrence of enterotoxigenic <italic>Staphylococcus aureus</italic> in diverse types of cheese (cow's milk cheese and mixed milk cheese) samples from R.N. Macedonia. Cheese samples were analyzed for enumeration and isolation of the <italic>S. aureus</italic> strains according to ISO 6888-1. We detected the toxigenic potential of the strains by the use of the Enzyme Link Fluorescent Assay VIDAS system, and we confirmed the presence of the SEs (<italic>sea, seb, sec, sed, see</italic>) genes by multiplex PCR. The results showed that out of 270 samples of cheese, coagulase-positive staphylococci (CPS) were detected in 27 (10%), and coagulase-negative staphylococci in five samples (1.8%). Biochemically, all 27 CPS samples were confirmed to be <italic>Staphylococcus aureus.</italic> With VIDAS SET2 test we confirmed that 11 isolates are producers of one of the toxins limited by the test. With the conventional PCR we confirmed genes in only 7 isolates. Most common detected gene was <italic>seb</italic> n=3 (42.8%), followed by <italic>sea</italic> n=2 (28.6%), and <italic>sec</italic> n=2 (28.6%). Additionally, <italic>sed</italic> and <italic>see</italic> genes were not detected in any of the <italic>S. aureus</italic> isolates. Discrepancies between the two test methods for detection of enterotoxigenic potential are not uncommon. The presence of viable <italic>Staphylococcus aureus</italic> cells that have enterotoxin potency demonstrates the importance of appropriate hygiene practices in the diary process and also the maintenance of the products in order to obtain a safe final product for the consumers.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00From a Rigid Cover to an Elastic One Via a Blanket too Short. An Adaptive Polygraph Approachhttps://sciendo.com/article/10.2478/ep-2021-0005<abstract> <title style='display:none'>Abstract</title> <p>The Polygraph test or the Psychophysiological Detection of Deception is a short blanket that cannot cover everything without paying in errors; a clever polygraph examiner and a wise usage of polygraph must make a choice whether to cover the feet or the head with this short blanket and conduct the examination accordingly. But a wiser approach should look to turn the short blanket into an elastic cover that can deal differently with different people and different situations.</p> <p>Following two-three decades of blessed efforts to develop strict standardization in the field, the time has come to start steering the polygraph ship back to greater flexibility and creativity, this time relying on scientific thinking and knowledge. Thus, contrary to the existing trend in the field, I call to drive modern Polygraphy towards developing a scientifically based approach that follows the motto of “Different Things to Different People and Different Situations”. In other words, I call for developing an adaptive approach or <italic>Adaptive Polygraphy.</italic> The Relevant Issue Gravity (RIG) Theory (<xref ref-type="bibr" rid="j_ep-2021-0005_ref_004">Ginton, 2009</xref>) is presented here as a major theoretical and practical carrier for evolving and shaping the <italic>Adaptive Polygraphy.</italic> The article analyzes the current situation and draws some lines to follow in developing an <italic>Adaptive Polygraphy</italic> approach.</p> </abstract>ARTICLE2022-01-21T00:00:00.000+00:00Summary of Doctoral Dissertationhttps://sciendo.com/article/10.2478/ep-2021-0010ARTICLE2022-01-21T00:00:00.000+00:00On the Influence of Sleep Deprivation on the Results of Polygraph Testinghttps://sciendo.com/article/10.2478/ep-2021-0006ARTICLE2022-01-21T00:00:00.000+00:00 by Jan Widacki, Polskie Towarzystwo Kryminalistyczne, Warszawa 2021https://sciendo.com/article/10.2478/ep-2021-0008ARTICLE2022-01-21T00:00:00.000+00:00Aleksandr Motlyach: , Izdatelstvo Osvita Ukrainy, Kyiv 2021, pp. 568 (in Russian)https://sciendo.com/article/10.2478/ep-2021-0009ARTICLE2022-01-21T00:00:00.000+00:00Major Ludwik Krzewiński, MD – the Creator of Polish Narcoanalysishttps://sciendo.com/article/10.2478/ep-2021-0007ARTICLE2022-01-21T00:00:00.000+00:00Serum collected from rats with myocardial infarction increases extracellular matrix accumulation by myofibroblasts isolated from myocardial infarction scarhttps://sciendo.com/article/10.2478/ebtj-2022-0001<abstract> <title style='display:none'>Abstract</title> <p>The effect on extracellular matrix content is believed to be an average of several serum derived compounds acting in opposition. The aim of the study is to determine whether whole serum of rats with myocardial infarction may modify the accumulation of extracellular matrix in cultures of myofibroblasts isolated from the myocardial infarction scar. A second aim is to determine whether the tested serum can also degranulate the mast cells. Serum was collected from rats with sham myocardial infarction, rats with myocardial infarction induced by coronary artery ligation and control animals. The experiments were carried out on myocardial infarction scar myofibroblasts or mast cells from the peritoneal cavity. The cultures were divided into three groups containing eight cultures each: one treated with serum from control rats, from animals after sham operation or from those after myocardial infarction. In all groups, the serum was used at concentrations of 10%, 20% or 30%. The total collagen content (Woesner method) glycosaminoglycan level (Farandale method), cell proliferation (BrdU), histamine secretion from mast cells (spectrofluorymetry), β1 integrin and α-smooth muscle actin expression (flow cytometry) were evaluated. Isolated cells were α-smooth muscle actin positive and identified as myofibroblasts. Serum derived from rats with myocardial infarction increased collagen and glycosaminoglycan content in the cultures and modified myofibroblast proliferation in a concentration-dependent manner. The serum also results in an imbalance between collagen and glycosaminoglycan levels. The content of β1 integrin was not influenced by myocardial infarction serum. The serum of rats with myocardial infarction is involved in regulation of collagen and glycosaminoglycan content in myofibroblast cultures, as well as the modification of their proliferation. These changes were not accompanied with integrin β1 density variations. The serum of the myocardial infarction rats did not influence the mast cell degranulation.</p> </abstract>ARTICLE2022-01-24T00:00:00.000+00:00SARS-CoV-2 Alpha Variant Infection of a Patient Immunized by Inactive Sinovac (CoronaVac) Vaccinehttps://sciendo.com/article/10.2478/ebtj-2022-0003<abstract> <title style='display:none'>Abstract</title> <p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in December 2019, and shortly after pandemic has been declared by the World Health Organization (WHO) due to its unstoppable global spread. Considerable amount of effort has beenput around the World in order to develop a safe and effective vaccine against SARS-CoV-2. Inactivated and RNA vaccines have already passed phase three studies showing sufficient efficacy and safety, respectively. Nowadays, there is a noticeable dominance of SARS-CoV-2 variants with various mutations over the wild type SARS-CoV-2. However, there is no report showing the efficacy of these vaccines on these variants. This case study describes a thirty-eight-year-old male reported to be infected with SARS-CoV-2 alpha variant following two doses of inactive CoronaVac administration with a protective level of SARS-CoV-2 specific antibodies. The variant analysis of the virus reported to be positive for N501Y mutation.This is the first case in the literature demonstrating that inactive SARS-CoV-2 vaccine might have a lower efficacy on alpha variant.</p> </abstract>ARTICLE2022-01-24T00:00:00.000+00:00en-us-1