Dragon fruit is a cactus species which is indigenous to Americas belongs to Genus Hylocereus. Dragon fruit is commonly known as Noble woman, Pitahaya, strawberry pear, Super fruit etc. It has antioxidant properties which prevents oxidation of cholesterol. Similarly, dragon fruit contains phytonutrient, minerals and vitamins which are beneficial to blood, tissue, bone and overall health. On research it was found out that Lycopene which is responsible for red colour in dragon fruit has been linked with a lower prostate cancer risk. Nowadays it is widely used in restaurant as fruit salad, refreshing drinks, Jams, Ice creams, Jelly, fruit juice, wine etc. In Nepal, Mr. Jagannath Rai brought dragon fruit from USA in 2057 B.S. and later Gorkha Millenium multipurpose cooperatives ltd formally started cultivation of dragon fruit in commercial level from 2070 B.S (2013 A.D). In Nepal there is a wide scope for cultivation as it can cultivate in region of less rainfall at altitude of 1500 from MASL. Availability of Fallow and marginal lands of Terai, Bhitri madhes, valleys and lower range of mountain are suitable for cultivation. Moreover, there are great possibilities of production of organic dragon fruits. Inspite of various benefits and possibilities, farmers’ condition and investment are major challenges for exploration of dragon fruit in Nepal.