1. bookVolume 8 (2020): Issue 3 (September 2020)
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31 Dec 2013
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Comment on “Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management”

Published Online: 25 Sep 2020
Page range: 199 - 199
Journal Details
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Format
Journal
First Published
31 Dec 2013
Publication timeframe
4 times per year
Languages
English
Copyright
© 2020 Sciendo
To the editor

We read interesting correspondence reported by Liu et al.[1] We would like to remind the forgotten aspects of ACE 2 enzyme.

ACE 2 enzyme doesn’t only hydrolyze angiotensin proteins, it also hydrolyzes ghrelin, Apelin-13 and other proteins.[2] ARB and ACEI may increase ACE2 enzyme, which may increase the infection and decrease apelin-13 and ghrelin levels.

Ghrelin and Apelin-13 are reported to be neuroprotective.[3,4] Also, after ischemic injury, ghrelin seems to improve recovery.[4] In COVID patients, taking these drugs may be more prone to stroke and other neurological complications. Decrease in ghrelin levels may increase the virus induced acute lung injury.5

Decreased level of these hormones may be responsible from several complications in COVID-19.

The other aspects of diseases and drugs that may effect ACE2 expression[1] is they may also effect the response of drugs targetting COVID-19. We don’t know if vaccine efficiency may also be affected by these factors.

Liu M, Wang T, Zhou Y, Zhao Y, Zhang Y, Li J. Potential Role of ACE2 in Coronavirus Disease 2019 (COVID-19) Prevention and Management. J Transl Int Med 2020; 8: 9–19.LiuMWangTZhouYZhaoYZhangYLiJPotential Role of ACE2 in Coronavirus Disease 2019 (COVID-19) Prevention and ManagementJ Transl Int Med 2020;8919Search in Google Scholar

Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxy-peptidase. J Biol Chem 2002; 277: 14838–43.VickersCHalesPKaushikVDickLGavinJTangJet alHydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxy-peptidaseJ Biol Chem20022771483843Search in Google Scholar

Bao H, Yang X, Huang Y, Qiu H, Huang G, Xiao H et al. The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage. Neurosci Lett 2016; 628: 219–24.BaoHYangXHuangYQiuHHuangGXiaoHet alThe neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhageNeurosci Lett201662821924Search in Google Scholar

Dong R, Chen M, Liu J, Kang J, Zhu S. Temporospatial effects of acyl-ghrelin on activation of astrocytes after ischaemic brain injury. J Neuroendocrinol 2019; 31: e12767.DongRChenMLiuJKangJZhuSTemporospatial effects of acyl-ghrelin on activation of astrocytes after ischaemic brain injuryJ Neuroendocrinol201931e12767Search in Google Scholar

Zheng H, Liang W, He W, Huang C, Chen Q, Yi H et al. Ghrelin attenuates sepsis-induced acute lung injury by inhibiting the NF-κB, iNOS, and Akt signaling in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2019; 317: L381–91.ZhengHLiangWHeWHuangCChenQYiHet alGhrelin attenuates sepsis-induced acute lung injury by inhibiting the NF-κB, iNOS, and Akt signaling in alveolar macrophagesAm J Physiol Lung Cell Mol Physiol2019317L38191Search in Google Scholar

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