1. bookVolume 67 (2021): Issue 2 (June 2021)
Journal Details
License
Format
Journal
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Attitude and awareness of medicinal plants in treatment of kidney lithiasis in eastern Morocco: a retrospective study

Published Online: 17 Jul 2021
Page range: 17 - 28
Received: 22 Nov 2020
Accepted: 07 May 2021
Journal Details
License
Format
Journal
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
Summary

Introduction: Kidney stone is a major public health problem. Over 5% of the population is affected by kidney stones, with causes a lifetime risk of transmitting renal lithiasis of about 8 to 10%.

Objective: The goal of our study is the attitude and awareness of lithiasis patients regarding the use of medicinal plants in eastern Morocco.

Methods: We carried out a study on lithiasis patients to retrospectively identify medicinal plants used in this disease, using a pre-established questionnaire. The study was carried out from 10 December 2017 to 28 February 2018.

Results: Our survey describes several medicinal plants used to treat renal lithiasis in eastern Morocco. Most patients used Herniaria hirsuta L., Zea mays L., Urtica dioica L., and Petroselinum crispum (Mill.) Fuss. This preliminary study showed that the first reason to use medicinal plants in half of lithiasis patients is to calm the pain and expel the stones. The primary source of plant use information is oral tradition. However 67% of lithiasis patients are unaware of the harmful and toxic effects that can appear.

Conclusion: Medicinal plants must, like medicines, comply with strict requirements and standard rules of use to which only the specialist in herbal medicine can respond and sensitize people to the dangers of irrational consumption of medicinal plants.

Keywords

1. Daudon M, Traxer O, Lechevallier E, Saussine C. Épidémiologie des lithiases urinaires. Progrès en Urol 2008; 18:802–14. doi: https://dx.doi.org/10.1016/j.purol.2008.09.029 Search in Google Scholar

2. Badalato GM, Cortes JAS, Gupta M. Treatment of upper urinary lithiasis in patients who have undergone urinary diversion. Curr Urol Rep 2011; 12(2):121-125. doi: https://dx.doi.org/10.1007/s11934-011-0175-3 Search in Google Scholar

3. Wasserstein AG. Epidemiology and natural history of nephrolithiasis. Clin Rev Bone Miner Metab 2011; 9(3-4):165-180. doi: https://dx.doi.org/10.1007/s12018-011-9097-3 Search in Google Scholar

4. Knoll T. Stone Disease. Eur Urol Suppl. 2007; 6:717-722. Search in Google Scholar

5. Davoudi-Kiakalayeh A, Mohammadi R, Pour-fathollah AA, Siery Z, Davoudi-Kiakalayeh S. Alloimmunization in thalassemia patients: new insight for healthcare. Int J Prev Med 2017; 8. doi: https://dx.doi.org/10.4103/ijpvm.IJPVM_246_16 Search in Google Scholar

6. Ramello A, Vitale C, Marangella M. Epidemiology of nephrolithiasis. J Nephrol 2000; 13:S45-50. Search in Google Scholar

7. Tabuti JRS, Lye KA, Dhillion SS. Traditional herbal drugs of Bulamogi, Uganda: plants use and administration. J Ethnopharmacol 2003; 88:19-44. doi: https://dx.doi.org/10.1016/S0378-8741(03)00161-2 Search in Google Scholar

8. Encyclopédie des plantes médicinales. Larousse, 2001. pdf, https://assomaleva.files.wordpress.com/2016/02/larousse-des-plantes-medicinales.pdf Search in Google Scholar

9. Bellakhdar J, Plantes médicinales au Maghreb et soins de bases. Précis de phytothérapie moderne. Casablanca. Éditions Le Fennec, 2019. Search in Google Scholar

10. George P. Concerns regarding the safety and toxicity of medicinal plants - An overview. J Appl Pharm Sci 2011; 01(06):40-44. Search in Google Scholar

11. Jamila F, Mostafa E. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J Ethnopharmacol 2014; 154(1):76-87. doi: https://dx.doi.org/10.1016/j.jep.2014.03.016. Search in Google Scholar

12. http://www.theplantlist.org. Search in Google Scholar

13. Guerrouj B El, Bouhrim M, Bentata Y, Daudon M, Melhaoui M, Kharchoufa L et al. Kidney stone disease (Urolithiasis): epidemiological study in the Eastern region of Morocco. Eur J Sci Res 2019; 155:40-57. Search in Google Scholar

14. El Guerrouj B, Bouhrim M, Bencheikh N, Im-tara H, Kharchoufa L, Ouassou H et al. Morphological and crystallographic analysis of kidney stones in Eastern. Mediterr J Chem 2020; 10(5):539-546. doi: http://dx.doi.org/10.13171/mjc10502005261409hi Search in Google Scholar

15. Bartoletti R, Cai T, Mondaini N, Melone F, Travaglini F, Carini M, Rizz M. Epidemiology and risk factors in urolithiasis. Urol Int 2007; 79(suppl. 1):3-7. 10.1159/000104434 Search in Google Scholar

16. Laziri F, Rhazifilali F, Amchhoud I. Etude rétrospective de la lithiase urinaire dans l’Hôpital Hassan II de la province de Settat (Maroc). African J Urol 2009; 15(2):117-123. [in French] Search in Google Scholar

17. Boumzaoued H, Laziri F, Lekhlifi Z El, Qarro A, Assyry A El. Prevalence of urinary lithiasis in the Moulay Ismail Military Hospital (Meknes-Morocco). J Mat Environ Sci 2015; 6(6):1578-1583. Search in Google Scholar

18. Bouatia M, Benramdane L, Idrissi MOB, Draoui M. An epidemiological study on the composition of urinary stones in Morocco in relation to age and sex. African J Urol 2015; 21(3):194-197. doi: https://dx.doi.org/10.1016/j.afju.2015.02.006 Search in Google Scholar

19. Muslumanoglu AY, Binbay M, Yuruk E, Akman T, Tepeler A, Esen T, Tefekli AH. Updated epidemiologic study of urolithiasis in Turkey. I : Changing characteristics of urolithiasis. Urol Res 2011; 39(4):309-314. doi: https://dx.doi.org/10.1007/s00240-010-0346-6 Search in Google Scholar

20. Ramirez CT, Morales EF, Gomez AZ, Alcaraz LG, Samper SDR. An epidemiological study of renal lithiasis in gypsies and others in Spain. J Urol 1984; 131(5):853-856. doi: https://dx.doi.org/10.1016/S0022-5347(17)50679-5 Search in Google Scholar

21. Johnson CM, Wilson DM, Fallon WMO, Malek RS, Kurland LT. Renal stone epidemiology: A 25-year study in Rochester, Minnesota. Kidney Int 1979; 16(5):624-631. doi: https://dx.doi.org/10.1038/ki.1979.173 Search in Google Scholar

22. Longtin Y, Sax H, Leape LL, Sheridan SE, Donaldson L, Pittet D. Patient Participation: Current knowledge and applicability to patient safety. Mayo Clin Proc 2010;85(1):53-62. doi: https://dx.doi.org/10.4065/mcp.2009.0248 Search in Google Scholar

23. World Health Organization. Topic 6: Understanding and managing clinical risk. Patient Saf Curr Guid 2015; 151-164. Search in Google Scholar

24. Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis : Alternative or complementary? Planta Med 2009; 75(10):1095-1103. doi: https://dx.doi.org/10.1055/s-0029-1185719 Search in Google Scholar

25. Nabi G, Downey P, Keeley F, Watson G, Mc-clinton S. Extra-corporeal shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi (review). Cochrane Database Syst Rev 2007; (4). doi: https://dx.doi.org/10.1002/14651858.CD006029 Search in Google Scholar

26. Dellabella M, Milanese G, Muzzonigro G. Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life. Urology 2005; 66(4):0-3. doi: https://dx.doi.org/10.1016/j.urology.2005.04.055 Search in Google Scholar

27. Barros ME, Schor N, Boim MA. Effects of an aqueous extract from Phyllanthus niruri on calcium oxalate crystallization in vitro. Urol Res 2003; 30:374-379. doi: https://dx.doi.org/10.1007/s00240-002-0285-y Search in Google Scholar

28. Atmani F, Farell G, Lieske JC. Extract from Herniaria hirsuta coats calcium oxalate monohydrate crystals and blocks their adhesion to renal epithelial cells. J Urol 2004; 172(4 Part 1):1510-1514. doi: https://dx.doi.org/10.1097/01.ju.0000131004.03795.c5 Search in Google Scholar

29. Oussama A, Touhami M, Mbarki M. In vitro and in vivo study of effect of lemon juice on urinary lithogenesis. Arch Esp Urol 2005; 58(10):1.087-1.092. doi: https://dx.doi.org/10.4321/S0004-06142005001000019 Search in Google Scholar

30. Ruth H, Laube N, Schneider A, Kessler T, Hesse A. Influence of grapefruit-, orange- and apple-juice consumption on urinary variables and risk of crystallization. Br J Nutr 2003; 90:295-300. doi: https://dx.doi.org/10.1079/BJN2003897 Search in Google Scholar

31. Jouad H, Haloui M, Rhiouani H, Hilaly J El, Eddouks M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez – Boulemane). J Ethnopharmacol 2001; 77:175-182. doi: https://dx.doi.org/10.1016/S0378-8741(01)00289-6 Search in Google Scholar

32. Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol 1997; 58(1):45-54. doi: https://dx.doi.org/10.1016/S0378-8741(97)00077-9 Search in Google Scholar

33. Eddouks M, Maghrani M, Lemhadri A, Ouahidi M, Jouad H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J Ethnopharmacol 2002; 82:97-103. doi: https://dx.doi.org/10.1016/S0378-8741(02)00164-2 Search in Google Scholar

34. Bellakhdar J, Claisse R, Fleurentin J, Younos C. Repertory of standard herbal drugs in the Moroccan pharmacopoea. J Ethnopharmacol 1991; 35:123-143. doi: https://dx.doi.org/10.1016/0378-8741(91)90064-K Search in Google Scholar

35. Nasri H, Shirzad H. Toxicity and safety of medicinal plants. J Herb Med Pharmacol 2013; 2:21-22. Search in Google Scholar

36. Asadbeigi M, Mohammadi T, Rafieian-Kopaei M, Saki K, Bahmani M, Delfan M. Traditional effects of medicinal plants in the treatment of respiratory diseases and disorders: an ethnobotanical study in the Urmia. Asian Pac J Trop Med 2014; 7(Suppl. 1):364-368. doi: https://dx.doi.org/10.1016/S1995-7645(14)60259-5 Search in Google Scholar

37. Farzaei MH, Abbasabadi Z, Ardekani MRS, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chinese Med 2013; 33(6):815-826. doi: https://dx.doi.org/10.1016/s0254-6272(14)60018-2 Search in Google Scholar

38. Zhang H, Chen F, Wang X, Yao H. Evaluation of antioxidant activity of parsley (Petroselinum crispum) essential oil and identification of its antioxidant constituents. Food Res Int 2006; 39:833-839. doi: https://dx.doi.org/10.1016/j.foodres.2006.03.007 Search in Google Scholar

39. Rezazad M, Farokhi F. Protective effect of Petroselinum crispum extract in abortion using pros-tadin-induced renal dysfunction in female rats. Avicenna J Phytomed 2014; 4(5):312-319. Search in Google Scholar

40. Kreydiyyeh SI, Usta J. Diuretic effect and mechanism of action of parsley. J Ethnopharmacol 2002; 79:353-357. doi: https://dx.doi.org/10.1016/S0378-8741(01)00408-1 Search in Google Scholar

41. Vamenta-Morris H, Dreisbach A, Shoemaker-Moyle M, Abdel-Rahman EM. Internet claims on dietary and herbal supplements in advanced nephropathy: Truth Myth Am J Nephrol 2014; 40(5):393-388. doi: https://dx.doi.org/10.1159/000368724 Search in Google Scholar

42. Al-yousofy F, Gumaih H, Ibrahim H, Alasbahy A. Parsley! Mechanism as antiurolithiasis remedy. J Clin Exp Urol 2017; 5(3):55-62. Search in Google Scholar

43. Atmani F, Khan S. Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. Bju Int 2000; 85(6):621-625. doi: https://dx.doi.org/10.1046/j.1464-410x.2000.00485.x Search in Google Scholar

44. Atmani F, Slimani Y, Mimouni M, Hacht B. Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats. Bju Int 2003; 92(1):137-140. doi: https://dx.doi.org/10.1046/j.1464-410X.2003.04289.x Search in Google Scholar

45. Atmani F, Slimani Y, Mimouni M, Aziz M, Hacht B, Ziyyat A. Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats. J Ethnopharmacol. 2004;95:87-93. doi: https://dx.doi.org/10.1016/j.jep.2004.06.028 Search in Google Scholar

46. Fouad A, Yamina S, Nait MA, Mohammed B, Abdlekrim R. In vitro and in vivo antilithiasic effect of saponin rich fraction isolated from Herniaria hirsuta. J Bras Nefrol 2006; 28(4):199-203. Search in Google Scholar

47. Prachi, Chauhan N, Kumar D, Kasana M. Medicinal plants of Muzaffarnagar district used in treatment of urinary tract and kidney stones. Indian J Trad Knowledge 2009; 8(2):191-195. Search in Google Scholar

48. Grases F, March J, Ramis M, Costa-Bauza A. Influence of Zea mays on urinary risk factors for kidney stones in rats. Phytother Res 1993; 7:146-149. doi: https://dx.doi.org/10.1002/ptr.2650070210 Search in Google Scholar

49. Velazquez DVO, Xavier HS, Batista JEM, Castro-chaves C De. Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats. Phytomedicine 2005; 12:363-369. doi: https://dx.doi.org/10.1016/j.phymed.2003.12.010 Search in Google Scholar

50. Zhang H, Li N, Li K, Li P. Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats. Mol Med Rep 2014; 10:3157-3162. doi: https://dx.doi.org/10.3892/mmr.2014.2610 Search in Google Scholar

51. Durak I, Biri H, Devrim E, Sözen S, Avci A. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther 2004; 3(9):855-857. doi: https://dx.doi.org/10.4161/cbt.3.9.1038 Search in Google Scholar

52. Ammor K, Mahjoubi F, Bousta D, Chaqroune A. Ethnobotanical survey of medicinal plants used in the treatment of kidney stones in region of Fez-Meknes, Morocco Kenza. Ethnobot Res Appl 2020; 19:1-12. Search in Google Scholar

53. Silambarasan R, Ayyanar M. An ethnobotanical study of medicinal plants in Palamalai region of Eastern Ghats, India. J Ethnopharmacol 2015; 172:162-178. doi: https://dx.doi.org/10.1016/j.jep.2015.05.046 Search in Google Scholar

54. Salhi S, Fadli M, Zidane L, Douira A. Etudes floristique et ethnobotanique des plantes médicinales de la ville de Kénitra (Maroc). LAZAROA 2010; 31:133-146. [in Frech] doi: https://dx.doi.org/10.5209/rev_LAZA.2010.v31.9 Search in Google Scholar

55. Benkhnigue O, Zidane L, Fadli M, Elyacoubi H, Rochdi A, Douira A. Etude ethnobotanique des plantes médicinales dans la région de Mechraâ Bel Ksiri (Région du Gharb du Maroc). Acta Bot Barcinonensia 2011; 53:191-216. [in French] Search in Google Scholar

56. El Hassani M, Douiri E., Bammi J, Zidane L, Badoc A, Douira A. Plantes médicinales de la Moyenne Moulouya (Nord-Est du Maroc). Ethnopharmacologia 2013; 50:39. Search in Google Scholar

57. Four treatises of Theophrastus von Hohenheim called Paracelsus. Sigerest H (ed.). Baltimore. Johns Hopkins University Press, 1996. Search in Google Scholar

58. Savithramma N, Sulochana C, Rao KN. Ethno-botanical survey of plants used to treat asthma in Andhra Pradesh, India. J Ethnopharmacol 2007; 113:54-61. doi: https://dx.doi.org/10.1016/j.jep.2007.04.004 Search in Google Scholar

59. Kharchoufa L, Merrouni IA, Yamani A, Elachouri M. Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns. Toxicon 2018; 154:90-113. doi: https://dx.doi.org/10.1016/j.toxicon.2018.09.003 Search in Google Scholar

60. Tülay AC. Potential genotoxic and cytotoxic effects of plant extracts. In: Bhattacharya A (ed.). A compendium of essays on alternative therapy. IntechOpen, 2012; 211-228. Search in Google Scholar

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