1. bookVolume 67 (2021): Issue 2 (June 2021)
Journal Details
License
Format
Journal
First Published
04 Apr 2014
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4 times per year
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English
access type Open Access

Nigerian polyherbal-based hydrotherapy: a panacea to infectious diseases

Published Online: 17 Jul 2021
Page range: 65 - 79
Received: 03 Jul 2020
Accepted: 04 Apr 2021
Journal Details
License
Format
Journal
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
Summary

A global society, including developed countries, continues to struggle with fatal diseases that are difficult to treat with Western medicine. A variety of infectious diseases have existed for ages, but in Africa they had been limited thanks to the Indigenous Knowledge System (IKS) prior to the introduction of cosmopolitan medicine. Influenza virus repression has been demonstrated by a number of herbal antivirals, yet the invaluable therapeutic potential of herbal medicine has been underestimated. Despite various reliable methods offered by Western medicine, the globally destructive COVID-19 pandemic requires a successful fight. The wisdom of African IKS used in tackling epidemics that have broken out in the past is brought to mind again. Pneumonia – a COVID-19 symptom, could be treated with polyherbal fomentation. Selected plants cultivated across Nigeria for hydrotherapy are under consideration to be used in proper doses. Given the potential associated with IKS, a multi-disciplinary approach involving experts in phytomedicine, ethnobotany, phytochemistry, plant physiology and ecology is necessary to unlock the therapeutic potential of traditional medicine.

Keywords

1. Romero-Daza N. Traditional medicine in Africa. Ann Am Acad Pol Soc Sci 2002; 583(1):173-176. doi: https://dx.doi.org/10.1177/000271620258300111 Search in Google Scholar

2. Abdullahi AA. Trends and challenges of traditional medicine in Africa. Afr J Trad Compl Alt Med 2011; 8(5 Suppl):115-123. Search in Google Scholar

3. Feierman S. Traditional medicine in Africa: colonial transformations. New York. Acad Med, 2002. Search in Google Scholar

4. Konadu K. Medicine and anthropology in twentieth century Africa: akan medicine and encounters with (medical) anthropology. Afr Stud Quart 2008; 2:45-69. https://www.researchgate.net/publication/286396045_Medicine_and_anthropology_in_twentieth_century_africa_Akan_medicine_and_encounters_with_medical_anthropology Accessed May 16, 2021. Search in Google Scholar

5. Millar D. Interfacing two knowledge systems: local knowledge and science in Africa. Paper for the Compas Panel in the Conference: Bridging Scales and Epistemologies: Linking Local Knowledge with Global Science in Multi-Scale Assessments. Alexandria 2004. Search in Google Scholar

6. Paul J. Medicine and imperialism in Morocco. MERIP Rep 1977; 60:3-12. Search in Google Scholar

7. Kshatriya RM, Khara NV, Ganjiwale J, Lote SD, Patel SN, et al. Lessons learnt from the Indian H1N1 (swine flu) epidemic: predictors of outcome based on epidemiological and clinical profile. J Fam Med Prim Care 2018; 7(6):1506-1509. Search in Google Scholar

8. How flu spreads. Centers for Disease Control and Prevention. https://www.cdc.gov/flu/about/disease/spread.htm Accessed April 4, 2020. Search in Google Scholar

9. Rewar S, Mirdha D, Rewar P. Treatment and prevention of pandemic H1N1 influenza. Ann Glob Health 2015; 81(5):645-53. Search in Google Scholar

10. Jilani TN, Jamil RT, Siddiqui AH. H1N1 influenza (swine flu). Stat Pearls 2020. Search in Google Scholar

11. Spreeuwenberg P, Kronman M, Paget J. Reassessing the global mortality burden of the 1918 influenza pandemic. Am J Epidemiol 2018; 187(12):2561-2567. doi: http://dx.doi.org/10.1093/aje/kwy191 Search in Google Scholar

12. World Health Organization. Ten things you need to know about pandemic influenza (update of 14 October 2005). Weekly Epidemiol Rec 2005; 80(49-50):428-31. https://apps.who.int/iris/handle/10665/232955 Search in Google Scholar

13. Moodie M. ‘World now at the start of 2009 influenza pandemic’ says World Health Organization; but no travel restrictions – 15/06/09. The Moodie Davitt Report Accessed May16, 2021. Search in Google Scholar

14. Fleming M. US flu cases reach 32 million, pediatric hospitalization rates hit record high. https://www.contagionlive.com/news/us-flu-cases-reach-32-million-pediatric-hospitalization-rates-hit-record-high Accessed April 14, 2020. Search in Google Scholar

15. Nobusawa E, Sato K. Comparison of the mutation rates of human influenza A and B viruses. J Virol 2006; 80:3675-3678. doi: http://dx.doi.org/10.1128/JVI.80.7.3675-3678 Search in Google Scholar

16. Ju-Young L, Michael EC, Abundo, Chang-Won L. Herbal medicines with antiviral activity against the influenza virus, a systematic review. Am J Chin Med 2018; 46(08). doi: https://dx.doi.org/10.1142/S0192415X18500854 Search in Google Scholar

17. Okuonzi S. Colonial masters brought infectious diseases to Africa. New Vision 2009. https://www.newvision.co.ug/new Accessed April 11, 2020. Search in Google Scholar

18. Bello RA. Integrating the traditional and modern health care system in Nigeria: a policy option for better access to health care delivery. In: Saliu H, Jimoh A, Arosanyin T, (eds.). The national question and some selected topical issues on Nigeria, Ibadan 2006. Search in Google Scholar

19. Erinosho OA. Health sociology for universities, colleges and health related institutions. Ibadan 1998. Search in Google Scholar

20. Jegede AS. Social epidemiology. In: Oke EA, Owumi, BE, (eds.). Readings in medical sociology. Ibadan 1996. Search in Google Scholar

21. Oke EA. Traditional health services: an investigation of providers and the level and pattern of utilization among the Yoruba’. Ibadan Sociol Series 1995; 1:2-5. Search in Google Scholar

22. Oyelakin RT. Yoruba traditional medicine and the challenge of integration. J Pan Afr Stud 2009; 3(3):73-90. Search in Google Scholar

23. Hassim A, Heywood M, Berger J. Health and democracy. http://www.alp.org.za Accessed January 12, 2010. Search in Google Scholar

24. WHO. Legal Status of Traditional Medicine and Complementary/Alternative Medicine: 2001. https://apps.who.int/iris/handle/10665/42452 Accessed May 5, 2021. Search in Google Scholar

25. Carpentier L, Prazuck T, Vincent-Ballereau F, Ouedraogo LT, Lafaix C. Choice of traditional of modern treatment in West Burkina Faso. World Health Forum 1995; 16:198-210. Search in Google Scholar

26. Amira OC, Okubadejo NU. Frequency of complementary and alternative medicine utilization in hypertensive patients. BMC Complement Altern Med 2007; 7:30. doi: https://dx.doi.org/10.1186/1472-6882-7-30 Search in Google Scholar

27. Roberts H. Accra: a way forward for mental health care in Ghana? Lancet 2001; 357(9271):1859. Search in Google Scholar

28. Lekotjolo N. Wits starts training of first 100 sangomas this year. The Times, July15, 2009:8. Search in Google Scholar

29. Mander M, Ntuli L, Diederichs N, Mavundla K. Economics of the traditional medicine trade in South Africa. South Afr Health Rev 2007. https://hdl.handle.net/10520/EJC35482 Accessed March 27, 2009. Search in Google Scholar

30. Corona Scanner 2020. Global Coronavirus Infections. https://corona-scanner.com/ Accessed June 30, 2020. Search in Google Scholar

31. Worldometer.2020. COVID-19 Coronavirus Pandemic. https://www.worldometers.info/coronavirus/ Accessed June 30, 2020. Search in Google Scholar

32. World Health Organization 2020. Coronavirus disease (COVID-19) advice for the public: Myth busters https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/myth-busters Accessed April 10, 2020. Search in Google Scholar

33. Kaseje N. Why Sub-Saharan Africa needs a unique response to COVID-19. World Economic Forum 2020. https://www.weforum.org/agenda/2020/03/why-sub-saharan-africa-needs-a-unique-response-to-covid-19/ Accessed April 10, 2020. Search in Google Scholar

34. National Health Commission of the People’s Republic of China. Notification of 2019-nCoV infection 2019. http://www.nhc.gov.cn/xcs/yqfkdt/202002/18546da875d74445bb537ab014e7a1c6.shtml Accessed February 17, 2020). (in Chinese). Search in Google Scholar

35. The Cable Nigeria 2020. https://news.google.com/articles/CBMiZGh0dHBzOi8vd3d3Ln-RoZWNhYmxlLm5nL21ha2luZGUtdGhlcmUtYXJlLWxvY2FsLXNvbHV0aW9ucy10by-1ib29zdC1pbW11bmUtc3lzdGVtLWFnYWluc3QtY29yb25hdmlydXPSAWhodHRwczovL3d3dy50aGVjYWJsZS5uZy9tYWtpbmR-lLXRoZXJlLWFyZS1sb2NhbC1zb2x1dGlvbnMtdG8tYm9vc3QtaW1tdW5lLXN5c3RlbS1hZ2F-pbnN0LWNvcm9uYXZpcnVzL2FtcA?hl=en-NG&gl=NG&ceid=NG%3Aen Accessed April 8, 2020. Search in Google Scholar

36. Nigerian Tribune Online 2020. https://tribuneonlineng.com/covid-19-ooni-urges-fg-state-govt-to-partner-herbal-medicine-practitioners-on-curative-measures/ Accessed April 3, 2020. Search in Google Scholar

37. Lawal IO, Grierson DS, Afolayan AJ. Phytotherapeutic information on plants used for the treatment of tuberculosis in Eastern Cape Province, South Africa. Evid-Based Compl Alt Med 2014; Article ID 735423, 11 pages. Search in Google Scholar

38. The Cable Nigeria, 2020. https://news.google.com/articles/CBMiZmh0dHBzOi8vd3d3Ln-RoZWNhYmxlLm5nL3dlbGwtY29uc2lkZXItdHJhZGl0aW9uYWwtbWVkaWNpb-mUtZm9yLWNvdmlkLTE5LXRyZWF0b-WVudC1zYXlzLWhlYWx0aC1taW5pc3R-lctIBamh0dHBzOi8vd3d3LnRoZWNhYmxlLm5nL3dlbGwtY29uc2lkZXItdHJhZG-l0aW9uYWwtbWVkaWNpbmUtZm9yLWN-vdmlkLTE5LXRyZWF0bWVudC1zYXlzLWhlYWx0aC1taW5pc3Rlci9hbXA?hl=en-NG&gl=NG&ceid=NG%3Aen Accessed April 8, 2020. Search in Google Scholar

39. Oliver BEP. Medicinal plants in Nigeria. Nig Arts, Sci Tech 1960; 6:74-89. Search in Google Scholar

40. Lawal IO, Grierson DS, Afolayan AJ. The antibacterial activity of Clausena anisata Hook, a South African medicinal plant. Afr J Trad Compl Alt Med 2015; 12(1):23-27. Search in Google Scholar

41. Ahmad I, Agil F, Owais M. Modern phytomedicine: turning medicinal plants into mixtures. John Wiley & Sons 2006. Search in Google Scholar

42. Subramani P, Gan ST, Sokkalingam AD. Polyherbal formulation: concept of ayurveda. Pharmacogn Rev 2014; 8(16):73-80. Search in Google Scholar

43. Butler David SO. A-Z of hydrotherapy. (5th ed.). Multijet 2005. Search in Google Scholar

44. Fleming SA, Gutknecht NC. Naturopathy and the primary care practice. Prim Care 2010; 37:119-136. Search in Google Scholar

45. Herz R S. Aromatherapy facts and fiction: a scientific analysis. Int J Neurosci 2009; 119(2):263-290. doi: https://dx.doi.org/10.1080/00207450802333953 Search in Google Scholar

46. Farooq S, Majeed A, Mohi-Ud-Din R, Ali Bhat Z. Treatment of various health ailments with herbal medicines: A review. Int J Info Comp Sci 2019; 6(3):0972-1347. Search in Google Scholar

47. Falodun A. Hebal medicine in Africa – distribution, standardization and prospects. Res J Phytochem 2010; 4(3):154-161. Search in Google Scholar

48. Murray MT, Pizzorno JE Jr. Botanical medicine - a modern perspective. In: Pizzorno JE Jr., Murray MT, (eds.). Textbook of natural medicine. Churchill Livingstone 2000; 1:267-79. Search in Google Scholar

49. Jianjun G, Zhenxue T, Xu Y. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of covid-19 associated pneumonia in clinical studies. Bio Sci Trends 2020; 14(1):72-73. doi: http://dx.doi.org/10.5582/bst.2020.01047 Search in Google Scholar

50. BBC News. Coronavirus and chloroquine: is there evidence it works? Accessed from https://www.bbc.com/news/51980731 Accessed April 15, 2020. Search in Google Scholar

51. Hay EM, Paterson SM, Lewis M, Hosie G, Roі P. Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. BJM 1999; 319:964. Search in Google Scholar

52. Lesko SM, Mitchell AA. An assessment of the safety of pediatric ibuprofen. JAMA 1995; 273:929-933. Search in Google Scholar

53. Mann JFE, Goering M, Brune K. Ibuprofen as an over-the-counter drug: Is there a risk for renal injury. Clin Nephrol 1993; 39:1-6. Search in Google Scholar

54. Moghal NE, Hegde S, Eastham KM. Ibuprofen and acute renal failure in a toddler. Arch Dis Child 2004; 89:276-277. Search in Google Scholar

55. Drugs.com. 2019. Chloroquine Side Effects. https://www.drugs.com/sfx/chloroquine-side-effects.html Accessed April 15, 2020. Search in Google Scholar

56. Haq I. Safety of medicinal plants. Pak J Med Res 2004; 43(4):203-210. Search in Google Scholar

57. Kazemipoor M, Radzi CW, Cordell GA, Yaze I. Safety, efficacy and metabolism of traditional medicinal plants in the management of obesity: a review. Int J Chem Eng Appl 2012; 3(4):288-292. Search in Google Scholar

58. Nasri H. Cisplatin therapy and the problem of gender-related nephrotoxicity. J Nephropharmacol 2013; 2(2):13-14. Search in Google Scholar

59. Philomena G. Concerns regarding the safety and toxicity of medicinal plants - An overview. J Appl Pharmac Sci 2011; 1(6):40-44. Search in Google Scholar

60. Kuete V. Health effects of alkaloids from African medicinal plants. Toxicol Survey African Med Plants. https://www.sciencedirect.com/topics/neuroscience/jatrorrhizine Accessed April 16, 2020. Search in Google Scholar

61. Pub Chem “Reserpine” National Centre for Bio-technology Information. https://pubchem.ncbi.nlm.nih.gov/compound/reserpine Accessed April 16, 2020. Search in Google Scholar

62. Moody JO, Robert VA, Connolly JD, Houghton PJ. Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae). J Ethnopharmacol 2006; 104(1-2):87-91. Search in Google Scholar

63. Ngnokam D, Ayafor JF, Connolly JD, Nuzillard JM. Nauclefolinine: a new alkaloid from the roots of Nauclea latifolia. Bull Chem Soc Ethiop 2003; 17(2):173-176. Search in Google Scholar

64. Al-Aamri MS, Al-Abousi NM, Al-Jabri SS, Alam T, Khan SA. Chemical composition and in vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. J Tai Univ Med Sci 2018; 13(2):108-112. doi: https://doi.org/10.1016/j.jtumed.2017.12.002 Search in Google Scholar

65. Ritchie E, Taylor WC. The constituents of Harungana madagascariensis Poir. Tetrahedron Letters 1964; 5(23):1431-1436. Search in Google Scholar

66. Devakumar C, Sukh D. Chemistry. Dev Soc Pestic Sci 1996:63-99. Search in Google Scholar

67. Adesegun SA, Coker HAB, Hamann MT. Anti-fungal triterpenoid saponin from Lecaniodiscus cupanioides. Res J Phytochem 2008; 2(2):93-98. Search in Google Scholar

68. Gonzalez-Coloma A, Fraga BM. Development & modification of bioactivity. In: Mander R., Hung-Wen L. (eds.). Comprehensive Natural Products II. 1st ed. 2010. Search in Google Scholar

69. Adotey JP, Adukpo GE, OpokuBoahen Y, Armah FA. A review of the ethnobotany and pharmacological importance of Alstonia boonei De Wild (Apocynaceae). ISRN Pharmacol 2012:587160. doi: https://dx.doi.org/10.5402/2012/587160 Search in Google Scholar

70. Igwe OU. Chemical constituents of the leaf essential oil of Carica papaya from South East Nigeria and its antimicrobial activity. Int J Res Pharm Chem 2015; 5(1):77-83. Search in Google Scholar

71. GeD-D, Zhang Y, Liu E-W, Hu L-M. Chemical constituents of Mangifera indica leaves (I). Chin Trad Herb Drug 2011; 42(3):428-431. Search in Google Scholar

72. Santas J, Almajano MP, Carbó R. Antimicrobial and antioxidant activity of crude onion (Allium cepa L.) extracts. Int J Food Sci Tech 2010; 45(2):403-409. Search in Google Scholar

73. Aladesanmi AJ. Tetrapleura tetraptera: molluscicidal activity and chemical constituents. Afr J Trad Compl Alt Med AJTCAM 2006; 4(1):23-36. Search in Google Scholar

74. Owolabi MS, Padilla-Camberos E, Ogundajo AL, Ogunwande IA, Flamini G, Yusuff OK et al. Insecticidal activity and chemical composition of the Morinda lucida essential oil against pulse beetle Callosobruchus maculatus. Sci World J 2014; 7. doi: https://dx.doi.org/10.1155/2014/784613 Search in Google Scholar

75. World Health Organization 2020. Updates on Novel Corona Virus (COVID-19). https://www.who.int/maldives/news/detail/31-01-2020-updates-on-novel-corona-virus-(COVID-19)#:~:text=The%20virus%20can%20cause%20a,sore%20throat%20and%20headaches Accessed June 28, 2020. Search in Google Scholar

76. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020; 323(13):1239-1242. Search in Google Scholar

77. Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Coronavirus (COVID-19) [Updated 2020 May 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776/. Search in Google Scholar

78. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77(6):683–690. doi: http://dx.doi.org/10.1001/jamaneurol.2020.1127 Search in Google Scholar

79. Agbaje EO, Onabanjo AO. Analgesic and antipyretic actions of Enantia chlorantha in some laboratory animals. Nig J Nat Prod Med 1998; 2:24–5. Search in Google Scholar

80. Agbaje EO, Tijani AY, Braimoh OO. Effects of Enantia chlorantha extracts in laboratory-induced convulsion and inflammation. Orient J Med 2003; 15(1):68–71. Search in Google Scholar

81. Fasola TR, Adeyemo FA, Adeniji JA, Akonko IO. Antiviral potentials of Enantia chlorantha on yellow fever virus. Nature and Science 2011; 9(9):99–105. Search in Google Scholar

82. Wafo P, Nyasse B, Fontaine C. 7,8-dihydro-8-hydroxy-palmitine from Enantia chlorantha. Phytochem 1999; 50:279–81. Search in Google Scholar

83. Olanlokun JO, Akomolafe SF. Antioxidant potentials of various solvent extracts from stem bark of Enantia chlorantha. J Biomed SciEng 2013; 6:877–84. Search in Google Scholar

84. Okwori AEJ, Okeke CI, Uzoechina A, Etukudoh NS, Amali MN, Adetunji JA, Olabode AO. The antibacterial potentials of Nauclea latifolia.Afr J Biotech 2008; 7(10):1394-1399. Search in Google Scholar

85. Abdullahi M, Amupitan JO, Oyawale AO, Okogun JI, Ibrahim K. An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State. Nig J Phytomedicine Therapeut 2007; 12:1-12. Search in Google Scholar

86. Manuela D, Nana HM, Ngane RAN, Gatsing D, Tchinda AT, Rovito R et al. In vitro anti-Herpes simplex virus activity of crude extract of the roots of Nauclea latifolia Smith (Rubiaceae). Complem Alt Med 2013; 13:266. Search in Google Scholar

87. Ademola OA, Oluwafemi OO, Nicole LB. In vitro study on the antioxidant potentials of the leaves and fruits of Nauclea latifolia. The Sci World J 2014; 23(4):23-33. Search in Google Scholar

88. Ngo Bum E, Taiwe GS, Moto FC, Ngoupaye GT, Nkantchoua GC, Pelanken MM, et al. Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. Epilepsy Behaviour 2009; 15(4):434-40. Search in Google Scholar

89. Taiwe GS, Ngo Bum E, Dimo T, Talla E, Weiss N, Dawe A, Moto FC, et al. Antidepressant, myorelaxant and anti-anxiety-like effects of Nauclea latifolia Smith (Rubiaceae) roots extract in murine models. Int J Pharm. 2010; 6(4):364-371. Search in Google Scholar

90. Abbah J, Amos S, Chindo B, Ngazali I, Vongtau HO, Adzu B et al. Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: Effects against nociception, inflammation, and pyrexia in rats and mice. J Ethnopharm 2010; 127(1):85-90. Search in Google Scholar

91. Scora RW. On the history and origin of citrus. Bulletin of the Torrey Botanical Club 102 1975; 6:369–375. Search in Google Scholar

92. SrinivasanD, Ramasamy S, Sengottuvelu S. Protective effect of polyherbal formulation on experimentally induced ulcer in rats. Pharm Online 2008; 1:331-350. Search in Google Scholar

93. Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H. Flavonoid composition of fruit tissues of citrus species. Biosci Biotech Biochem 2006; 70:178-192. Search in Google Scholar

94. Garg A, Garg S, Zaneveld LJD, Singla A. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 2001; 15(8):655-669. Search in Google Scholar

95. Cerletti C, Gianfagna F, Tamburrelli C, De Curtis A, D’Imperio M, Coletta W et al. Orange juice intake during a fatty meal consumption reduces the postprandial low-grade inflammatory response in healthy subjects. Thromb Res 2015; 135(2):255-259. Search in Google Scholar

96. Amandeep S, Bilal AR, Bevguni A. In vitro antibiotic activity of isolated volatile oil of Citrus sinensis. IJPRD 2009; 7:1-4. Search in Google Scholar

97. Sofidiya MO, Jimoh FO, Aliero AA, Afolayan AJ, Odukoya OA, Familoni OB. Antioxidant and antibacterial properties of Lecaniodiscus cupanioides. Res J Microbiol 2008; 3(2):91-98. doi: http://dx.doi.org/10.1055/s-2007-986993. Search in Google Scholar

98. Peer PA, Trivedi PC, Nigade PB, Ghaisas MM, Deshpande AD. Cardioprotective effect of Azadirachta indica A. Juss. onisoprenaline induced myocardial infarction in rats. Int J Cardiol 2008; 126:123-6. Search in Google Scholar

99. Sithisarn P, Supabphol R, Gritsanapan W. Anti-oxidant activity of Siamese Neem tree (VP1209). J Ethnopharmacol 2005; 99:109-12. Search in Google Scholar

100. Bhanwra S, Singh J, Khosla P. Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. Indian J Physiol Pharmacol 2000; 44:64-8. Search in Google Scholar

101. Abdel Moneim AE. Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats. Indian J Pharmacol 2014; 46:316-21. Search in Google Scholar

102. Abdel Moneim AE, Othman MS, Aref AM. Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. Biomed Res Int 2014; 2014:647131. Search in Google Scholar

103. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992; 14:1187-93. Search in Google Scholar

104. Dholi SK, Ramakrishna R, Mankala SK, Nagappan K. In vivo antidiabetic evaluation of neem leaf extract in alloxan induced rats. J Appl Pharmaceut Sci 2011; 7:100-5. Search in Google Scholar

105. Ghimeray AK, Jin C, Ghimine BK, Cho DH. Antioxidant activity and quantitative estimation of azadirachtin and nimbin in Azadirachta indica A. Juss grown in foothills of Nepal. Afr J Biotechnol 2009; 8:3084-91. Search in Google Scholar

106. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 2020; 105949. Search in Google Scholar

107. Lauricella M, Emanuele S, Calvaruso G, Giuliano M, D’Anneo A. Multifaceted health benefits of Mangifera indica L. (Mango): The inestimable value of orchards recently planted in sicilian rural areas. Nutrients 2017; 9(6):525 Search in Google Scholar

108. Adeyemi TOA, Ogboru RO, Idowu OD, Owoeye EA, Isese MO. Phytochemical screening and health potentials of Morinda lucida Benth. IJISR 2014; 11:515-519. Search in Google Scholar

109. Didunyemi MO, Adetuyi BO, Oyebanjo OO. Morinda lucida attenuates acetaminophen-induced oxidative damage and hepatotoxicity in rats. J Biomedical Sci 2019; 8(2):5. Search in Google Scholar

110. Panda A, Jena S, Sahu, PK, Nayak, S, Padhi P. Effect of polyherbal mixtures on the treatment of diabetes. ISRN Endocrinology 2013; 934797.https://dx.doi.org/10.1155/2013/934797 Search in Google Scholar

111. Adam AA, Omogbene TO. Phytochemical and phytomineral (macro and trace) compositions of the leaf, stem bark and root of Blighia sapida K.D. Koenig. J Med Plants Studies 2020; 8(5):20-24. https://dx.doi.org/10.22271/plants.2020.v8.i5a.1190 Search in Google Scholar

112. European Parkinson’s Disease Association (EPDA) 2021. Hydrotherapy. Accessed from https://www.epda.eu.com/living-well/therapies/complementary-therapies/hydrotherapy/#:~:text=Hydrotherapy%20is%20particularly%20helpful%20for,helps%20strengthen%20muscles%20and%20limbs on March 16, 2021. Search in Google Scholar

113. Lehrner J, Marwinski G, Lehr S, Johren P, Deecke L. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiology &Behavior 2005; 86: 92–95. Search in Google Scholar

114. Iwu, M. Handbook of African Medicinal Plants. Boca Raton. CRC Press, 1993. Search in Google Scholar

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