1. bookVolume 67 (2021): Issue 1 (March 2021)
Journal Details
License
Format
Journal
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells

Published Online: 21 May 2021
Page range: 35 - 45
Received: 15 Aug 2020
Accepted: 17 Mar 2021
Journal Details
License
Format
Journal
First Published
04 Apr 2014
Publication timeframe
4 times per year
Languages
English
Summary

Introduction: Psoriasis is an inflammatory skin disease characterized by hyper-proliferation, abnormal epidermal keratinocytes and inflammatory infiltration. It affects approximately 4% of the population globally. Herbal extracts have better results with less toxic effects than the synthetic drugs in the treatment of psoriasis.

Objective: Present study was aimed to access the anti-psoriatic effect of andrographolide extracted from Andrographis paniculate (A. paniculata).

Method: We extracted, characterized, and screened the extracted andrographolide for anti-proliferative characteristics using cultured cell model of human HaCaT keratinocyte.

Results: Andrographolide at 31.25 µg/mL (90 µM) demonstrated significant inhibitory effect on human HaCaT keratinocytes proliferation in cell culture. To our best knowledge, we reported the anti-proliferative potency of andrographolide extracted from A. paniculata for the first time.

Conclusion: The results suggest that the andrographolide extracted from A. paniculata plant may have potential to be used in the management of psoriasis.

Keywords

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