1. bookVolume 2 (2019): Issue 1 (April 2019)
Journal Details
License
Format
Journal
eISSN
2601-9388
First Published
30 Sep 2018
Publication timeframe
2 times per year
Languages
English
access type Open Access

The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

Published Online: 04 May 2019
Volume & Issue: Volume 2 (2019) - Issue 1 (April 2019)
Page range: 58 - 66
Received: 29 Nov 2018
Accepted: 05 Jan 2019
Journal Details
License
Format
Journal
eISSN
2601-9388
First Published
30 Sep 2018
Publication timeframe
2 times per year
Languages
English
Abstract

Red blood cell distribution width (RDW) is a hematological parameter usually measured with every complete blood count. Its place in daily practice is mainly in the differential diagnosis of anemia, but nowadays, researchers are focused on different approaches for the erythrocyte’s changes in function and morphology.

Sepsis and its most advanced form, septic shock, induces profound disturbances into organ system’s function and morphology. The red blood cells physiology and structure are directly and indirectly altered by these im balances produced in sepsis. RDW was studied in many diseases, like acute heart failure, acute stroke, inflammatory bowel diseases, chronic lung diseases and cancer, but also in sepsis. Its changes are seen to be mainly associated with prognosis. Higher values of RDW are correlated with mortality and severity of illnes in septic and all-cause critically ill patients. RDW was studied also as an independent variable in different predictive scores and some studies suggest it should be introduced in the scores use on a daily basis in critical care settings and emergency departments.

In this review we will focus on how RDW was associated with mortality and severity of illness in the recent literature, as an independent prognosis factor and as a component part in different predictive and severity scores.

Keywords

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