1. bookVolume 14 (2014): Issue 2 (April 2014)
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
access type Open Access

Acute-Phase Response in Monitoring Postoperative Recovery in Bitches After Ovariohysterectomy

Published Online: 25 Apr 2014
Volume & Issue: Volume 14 (2014) - Issue 2 (April 2014)
Page range: 287 - 295
Received: 20 Sep 2013
Accepted: 27 Jan 2014
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
Abstract

An ovariohysterectomy is one of the most common procedures performed on bitches in everyday veterinary practice. As with any other surgery, it leads to a local inflammatory reaction, which is usually accompanied by a systemic reaction called the acute-phase response (APR). The aim of the study was to assess the changes of serum CRP concentration, WBC and rectal temperature during the postoperative period in bitches undergoing ovariohysterectomy and to establish the usefulness of such determinations after surgical trauma. The results showed increased levels of all the measured parameters 24 hours after surgery. During the course of a normal postoperative period, WBC count and rectal temperature return to values that are considered physiological norms for dogs. The subsequent decline in CRP during the postoperative course indicates the gradual subsidence of the inflammatory reaction to surgical trauma. CRP concentrations higher than the physiological norm noted 10 days after surgery indicate a persistent, although less severe inflammatory process. The serum concentration of CRP is a more sensitive and reliable parameter for an evaluation of the postoperative period in bitches than WBC count and rectal temperature

Keywords

Baumann H., Gauldie J. (1994). The acute phase response. Immunol. Today, 15: 74-80. Search in Google Scholar

Buttenschoen K., Buttenschoen D.C., Berger D., Vasilescu C., Schafheutle S., Goeltenboth B., Seidelmann M. (2001). Endotoxemia and acute-phase proteins in major abdominal surgery. Am. J. Surg., 181: 36-43.Search in Google Scholar

Casella S., Fazio F., Russo C., Giudice E., Piccione G. (2013). Acute phase proteins response in hunting dogs. J. Vet. Diagn. Invest., 25: 577-580.Search in Google Scholar

Cerón J.J., Eackersall P.D., Martinez - Subiela S. (2005). Acute phase proteins in dogs and cats; current knowledge and future perspectives. Vet. Clin. Path., 34: 85-99.Search in Google Scholar

Cray C. (2012). Acute phase proteins in animals. Prog. Mol. Biol. Transl., 105: 113-150.Search in Google Scholar

Dąbrowski R., Kostro K., Lisiecka U., Szczubiał M., Krakowski L. (2009). Usefulness of C-reactive protein, serum amyloid Acomponent, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications. Theriogenology, 72: 471-479.Search in Google Scholar

Eckersall P.D. (2000). Recent advances and future prospects for the use of acute phase proteins as markers of disease in animals. Rev. de Medicina Veterinaria, 151: 577-584.Search in Google Scholar

Eckersall P.D., Bell R. (2010). Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet. J., 185: 23-27.Search in Google Scholar

Georgieva T.M., Zapryanova D., Nikiforo I., Denev S.A. (2013). Plasma C-reactive protein concentration in dogs with experimentally-induced Staphylococcus aureus infection. Rev. Méd. Vét., 164: 156-161.Search in Google Scholar

Gogo P.B., Schneider D.J., Terrien E.F., Watkins M.W., Sobel B.E., Dauerman H.L. (2005). Relation of leukocytosis to C-reactive protein and interleukin-6 among patients undergoing percutaneous coronary intervention. Am. J. Cardiol., 96: 538-542.Search in Google Scholar

Hayashi S., Jinbo T., Iguchi K., Shimizu M., Shimada T., Nomura M., Ishida Y., Yamamoto S. (2001). Acomparison of the concentrations of C-reactive protein and alpha1-acid glycoprotein in the serum of young and adult dogs with acute inflammation. Vet. Res. Commun., 25: 117-126.Search in Google Scholar

Ho Ch.S.K, Lόpez J.A., Vuckovic S., Pyke Ch.M., Hockey R.L., Hart D.N.J. (2001). Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts. Blood, 98: 140-145.Search in Google Scholar

Ito K., Asano T., Yoshii H., Satoh A., Sumitomo M., Hayakawa M. (2006). Impact of thrombocytosis and C-reactive protein elevation on the prognosis for patients with renal cell carcinoma. Int. J. Urol., 13: 1365-1370.Search in Google Scholar

Kajikawa T., Furuta A., Onishi T., Tajima T., Sugii S. (1999). Changes in concentrations of serum amyloid Aprotein, α1-acid glycoprotein, haptaglobin, and C-reactive protein in feline sera due to induced inflammation and surgery. Vet. Immunol. Immunop., 68: 91-98.Komar E. (1998). Anaesthesia of domestic and laboratory animals (in Polish), p. 17.Search in Google Scholar

Kostro K., Gliński Z., Wojcicka - Lorenowicz K., Krakowski L. (2001 a). Diagnostic usefulness of determining acute phase proteins in dogs and cats (in Polish). Mag. Wet., 10: 42-44.Search in Google Scholar

Kostro K., Gliński Z., Wójcicka - Lorenowicz K., Krakowski K. (2001 b). Acutephase proteins as indicators of diseases in animals. Med. Weter., 57: 539-542.Search in Google Scholar

Martinez - Subiela S., Tecles F., Parra M.D., Ceron J.J. (2003). Analytical validation of different methods for determination of main acute phase proteins in canine serum samples. Proc. 4th European Colloquium on Acute Phase Protein, 25-26.09.2003, Segovia, Spain, p. 142.Search in Google Scholar

Mattila- Vuori A., Salo M., Iisalo E., Pajulo O., Viljanto J. (2000). Local and systemic immune response to surgery under balanced anaesthesia in children. Pediatr. Anesth., 10: 381-388.Search in Google Scholar

Mold C., Rodriguez W., Rodic- Polic B., Du Clos T.W. (2002). C-reactive protein mediates protection from lipopolysaccharide through interactions with Fcγ R. J. Immunol., 169: 7019-7025.Search in Google Scholar

Murata H., Shimada N., Yoshioka M. (2004). Current research on acute phase proteins in veterinary diagnosis: an overview. Vet. J., 168: 28-40.Search in Google Scholar

Ozaka M., Ishii H., Yukisawa S. (2012). High C-reactive protein (CRP) level and leukocytosis asaprognostic factor for metastatic pancreatic cancer (MPC) patients with good performance status. American Society Clinical Oncology, J. Clin. Oncol., 30, (Suppl.; Abstr. no. e14677).10.1200/jco.2012.30.15_suppl.e14677Search in Google Scholar

Petersen L.H., Aalbaek B., Rontved C.M., Ingvartsen K.L., Sorensen N.S., Hee- gaard P.M., Jensen H.E. (2003). Early pathogenesis and inflammatory response in experimental bovine mastitis due to Streptococcus uberis. J. Comparat. Pathol., 128: 156-164.Search in Google Scholar

Planellas M., Bassols A., Siracusa C., Saco C., Giménez M., Pato R., Pastor J. (2009). Evaluation of serum haptoglobin and C-reactive protein in dogs with mammary tumors. Vet. Clin. Pathol., 38: 348-352.Search in Google Scholar

Póvoa P., Almeida E., Moreira P., Fernandes A., Mealha R., Aragao A., Sabino H. (1998). C-reactive protein as an indicator of sepsis. Intensive Care Medicine, 24: 1052-1056.Search in Google Scholar

Póvoa P. (2002). C-reactive protein:avaluable marker of sepsis. Intens. Care Med., 28: 235-243. Search in Google Scholar

Serin G., Ulutas P.A. (2010). Measurement of serum acute phase proteins to monitor postoperative recovery in anoestrous bitches after ovariohysterectomy. Vet. Rec., 166: 20-22.Search in Google Scholar

Shida T., Kuribayashi T., Seita T., Maruo T., Yamamoto S. (2011). Characteristic of C-reactive protein (CRP), α1-acid glycoprotein (AAG) and serum amyloid A (SAA) in dogs and cats with malignant cancer. J. Appl. Res. Vet. Med., 9: 376-381.Search in Google Scholar

Siracusa C., Manteca X., Cerón J., Martínez - Subiela S., Cuenca R., Lavín S., Garcia F., Pastor J. (2008). Perioperative stress response in dogs undergoing elective surgery: variations in behavioural, neuroendocrine, immune and acute phase responses. Anim. Welfare, 15: 259-273.Search in Google Scholar

Suffredi A.F., Fantuzzi G., Badolato R., Oppenheim J.J., O ’ Grady N.P. (1999). New insights into the biology of the acute phase response. J. Clin. Immunol., 19: 203-214.Search in Google Scholar

Tecles F., Tecles F., Caldín M., Zanella A., Membiela F., Tvarijonaviciute A., Subiela S.M., Cerón J.J. (2009). Serum acute phase protein concentrations in female dogs with mammary tumors. J. Vet. Diagn. Invest., 21: 214-219.Search in Google Scholar

Ulutas P.A., Musal B., Kiral F., Bildik A. (2009). Acute phase protein levels in pregnancy and oestrus cycle in bitches. Res. Vet. Sci., 86: 373-376.Search in Google Scholar

Yamamoto S., Shida T., Miyaji S., Santsuka H., Fujise H., Mukawa K., Furuka - wa E., Nagae T., Naiki M. (1993). Changes in serum C-reactive protein levels in dogs with various disorders and surgical trauma. Vet. Res. Commun., 17: 85-93.Search in Google Scholar

Zheng H., Fletcher D., Kozak W., Jiang M., Hofmann K.J., Corn C.A., Soszyń - ski D., Grabiec Ch., Trumbauer M.E., Shaw A., Kostura M.J., Stevens K., Ros- en H., Rosen H., North R.J., Chen H.Y., Tocci M.J., Kluger M.J., Vander Ploe g L.H.T. (1995). Resistance to fever induction and impaired acute-phase response in interleukin-1β- deficient mice. Immunity, 3: 9-19.Search in Google Scholar

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