The Journal of Croatian Pharmaceutical Society

Acta Pharmaceutica

<abstract><title style='display:none'>Abstract</title> Our previous reports showed that the cyclic-AMP-response element-binding protein (CREB) served as a proto-oncogene in the process of tumorigenesis and mediated the growth and metastatic activity of renal cancer cells. Our study, therefore, explored the role of CREB in sorafenib- -inhibited cell proliferation, migration and invasion. Renal cancer cells were cultured in medium containing sorafenib for 12, 24, 48 and 72 h. The MTT assay was used to study the cytotoxic effects of sorafenib. Cell invasion and migration were assayed in wound healing and transwell experiments, respectively. Protein expression levels were evaluated by western blotting. The results show that sorafenib treatment decreased cell viability in a dose- and time-dependent manner. Sorafenib inhibited cell migration and invasion and decreased the expression of MMP-2 and MMP-9. Moreover, addition of the recombinant plasmid pCI-neo/ CREB (PN) reversed the sorafenib-induced inhibition of cell proliferation, migration and invasion. These results show that CREB is associated with the sorafenib-induced inhibition of proliferation, migration and invasion.</abstract>

Abstract

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<article-title>The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion</article-title>

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

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Editor-in-Chief Svjetlana Luterotti, Zagreb, Croatia Managing Editor Maja Jakševac Mikša, Zagreb, Croatia Editorial Board Karmela Barišić (Zagreb), Jelena Filipović-Grčić (Zagreb), Mojca Kerec Kos (Ljubljana), Jasmina Lovrić (Zagreb), Svjetlana Luterotti (Zagreb), Željan Maleš (Zagreb), Izidor Sosič (Ljubljana), Željka Vanić (Zagreb), Donatella Verbanac (Zagreb), Branka Zorc (Zagreb), Alenka Zvonar Pobirk (Ljubljana) International Advisory Board Rudolf Bauer (Graz), Cristian-Catalin Gavat (Iasi), Atillâ Hincal (Ankara), Ivan Jalšenjak (Zagreb), Hans E. Junginger (Marburg), M. Zahirul I. Khan (Melbourne), Péter Mátyus (Budapest), Beatrice Perissutti (Trieste), Stane Srčič (Ljubljana) Technical Editor Branka Zorc, Zagreb, Croatia Contacts Professor Svjetlana Luterotti, PhD Editor-in-Chief Croatian Pharmaceutical Society, Masarykova 2, HR-10000 Zagreb, Croatia e-mail: <A href="mailto:svjetlana.luterotti@pharma.hr">svjetlana.luterotti@pharma.hr</A>; <A href="mailto:svjetlana.luterotti@gmail.com">svjetlana.luterotti@gmail.com</A> Professor Branka Zorc, PhD Technical Editor Faculty of Pharmacy and Biochemistry University of Zagreb, HR-10000 Zagreb, Ante Kovačića 1 e-mail: <A href="mailto:bzorc.AP@farmaceut.org">bzorc.AP@farmaceut.org</A> Maja Jakševac-Mikša, PhD Managing Editor Croatian Pharmaceutical Society, HR-10000 Zagreb, Masarykova 2 phone: +385 1 48 72 849; fax: +385 1 48 72 853 e-mail: <A href="mailto:maja.jaksevac-miksa@zg.t-com.hr">maja.jaksevac-miksa@zg.t-com.hr</A>; <A href="mailto:hfd-fg-ap@zg.t-com.hr">hfd-fg-ap@zg.t-com.hr</A>; <A href="mailto:info@farmaceut.org">info@farmaceut.org</A> Section Editors Karmela Barišić Mojca Kerec Kos Željka Vanić Donatella Verbanac Publisher De Gruyter Poland Bogumiła Zuga 32A Str. 01-811 Warsaw, Poland phone: +48 22 701 50 15

Acta Pharmaceutica

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

Shuaishuai Huang,
Shuaishuai Huang,
Pinger Cui,
Pinger Cui,
Shuangxia Lin,
Shuangxia Lin,
Xuping Yao,
Xuping Yao,
Xue Wang,
Xue Wang,
Yu Ren and
Yu Ren and
Guobin Weng
Guobin Weng

Published Online: 03 Oct 2018

Volume & Issue: Volume 68 (2018) - Issue 4 (December 2018)

Page range: 497 - 506

Received: 13 Jun 2018

Accepted: 16 Jul 2018

Journal & Issue Details

Acta Pharmaceutica

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Recent Articles

Acta Pharmaceutica

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

Shuaishuai Huang,Shuaishuai Huang,Pinger Cui,Pinger Cui,Shuangxia Lin,Shuangxia Lin,Xuping Yao,Xuping Yao,Xue Wang,Xue Wang,Yu Ren andYu Ren andGuobin WengGuobin Weng

Published Online: 03 Oct 2018

Volume & Issue: Volume 68 (2018) - Issue 4 (December 2018)

Page range: 497 - 506

Received: 13 Jun 2018

Accepted: 16 Jul 2018

Journal & Issue Details

Acta Pharmaceutica

PDF Preview

Recent Articles

Shuaishuai Huang,
Shuaishuai Huang,
Pinger Cui,
Pinger Cui,
Shuangxia Lin,
Shuangxia Lin,
Xuping Yao,
Xuping Yao,
Xue Wang,
Xue Wang,
Yu Ren and
Yu Ren and
Guobin Weng
Guobin Weng