1. bookVolume 127 (2017): Issue 4 (December 2017)
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First Published
23 Apr 2014
Publication timeframe
4 times per year
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English
access type Open Access

Effect of renalase (RNLS) gene polymorphisms (rs1088700 and rs2576178) on plasma RNLS level in hemodialyzed patients affected by arterial hypertension and coronary artery disease

Published Online: 25 Jul 2018
Page range: 147 - 150
Journal Details
License
Format
Journal
First Published
23 Apr 2014
Publication timeframe
4 times per year
Languages
English

Introduction. We have previously reported that rs10887800 and rs2576178 renalase (RNLS) single nucleotide polymorphisms (SNPs) are associated with the susceptibility to arterial hypertension (HY) and coronary artery disease (CAD) in hemodialyzed patients (HD). However, the underlying mechanism of this link remains undefined.

Keywords

1. Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296-305.Search in Google Scholar

2. Burmeister JE, Mosmann CB, Costa VB, et al. Prevalence of cardiovascular risk factors in hemodialysis patients – The CORDIAL Study. Arq Bras Cardiol. 2014;102:473-80.Search in Google Scholar

3. Weiner DE, Tabatabai S, Tighiouart H, et al. Cardiovascular outcomes and all-cause mortality: exploring the interaction between CKD and cardiovascular disease. Am J Kidney Dis. 2006;48:392-401.Search in Google Scholar

4. Longenecker JC, Coresh J, Powe NR, et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: The CHOICE Study. J Am Soc Nephrol. 2002;13:1918-27.Search in Google Scholar

5. Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney Int. 2009;76:366-70.Search in Google Scholar

6. Stec A, Semczuk A, Furmaga J, et al. Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension. Nephrol Dial Transplant. 2012;27:4162-6.Search in Google Scholar

7. Stec A, Ksiazek A, Buraczynska M. Rs10887800 renalase gene polymorphism is associated with an increased risk of coronary artery disease in hemodialyzed patients. Int Urol Nephrol. 2016;48:871-6.Search in Google Scholar

8. K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis. 2005;45(4 Suppl 3):S1-153.Search in Google Scholar

9. Stec A. Rs10887800 renalase gene polymorphism influences the level of circulating renalase in patients undergoing hemodialysis but not in healthy controls. BMC Nephrol. 2017;18:118.Search in Google Scholar

10. Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Curr Opin Nephrol Hypertens. 2008;17:181-5.Search in Google Scholar

11. Baraka A, El Ghotny S. Cardioprotective effect of renalase in 5/6 nephrectomized rats. J Cardiovasc Pharmacol Ther. 2012;17:412-6.Search in Google Scholar

12. Desir GV, Tang L, Wang P, et al. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. J Am Heart Assoc. 2012;1: e002634.Search in Google Scholar

13. Zbroch E, Malyszko J, Malyszko JS, et al. Renalase, a novel enzyme involved in blood pressure regulation, is related to kidney function but not to blood pressure in hemodialysis patients. Kidney Blood Press Res. 2012;35:395-9.Search in Google Scholar

14. Zbroch E, Malyszko J, Malyszko J, et al. Renalase in peritoneal dialysis patients is not related to blood pressure, but to Dialysis Vintage. Perit Dial Int. 2012;32:348-51.Search in Google Scholar

15. Oguz EG, Gursoy GK, Yayar O, et al. Increased serum renalase in hemodialysis patients: is it related to left ventricular hypertrophy? Ren Fail. 2016;38:1180-6.Search in Google Scholar

16. Dziedzic M, Petkowicz B, Bednarek-Skublewska A, et al. Relationship between renalase and N-terminal pro-B-type natriuretic peptide (NT pro-BNP) in haemodialysis patients. Ann Agric Environ Med. 2014;21:132-5.Search in Google Scholar

17. Shemin D, Bostom AG, Laliberty P, et al. Residual renal function and mortality risk in hemodialysis patients. Am J Kidney Dis 2001;38:85-90.Search in Google Scholar

18. Zbroch E, Musialowska D, Koc-Zorawska E, Malyszko J. Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis. Clin Interv Aging. 2016;11:1545-50.Search in Google Scholar

19. Manning AK, Hivert MF, Scott RA, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012;44:659-69.Search in Google Scholar

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