Methicillin antibiotic was first introduced in 1959. It is not long after its introduction, methicillin-resistant. Methicillin-resistant
Through horizontal gene transfer,
MRSA can cause a wide range of infections such as endocarditis, septicemia, osteomyelitis, and soft tissue infections . They could start with nasal colonization at hospital admission and subsequently became widespread and could be life-threatening . Therefore, it is essential that providers identify MRSA early so that prompt and timely treatment can be given to achieve desirable outcomes. Traditional methods used to process surveillance cultures take 48–72 h to yield results. However, newer techniques shorten the amount of time required to detect MRSA in surveillance cultures. There are a variety of chromogenic agars available that can detect MRSA stains within 24 h. One of these chromogenic selective agars contains cefoxitin and detects a majority of MRSA isolates within 24 h, while commercially available real-time PCR tests for
The gold standard for the detection of MRSA is PCR of the
The phenotypic methods commonly used for MRSA identification include oxacillin MIC (agar dilution/broth dilution) or E-strip, oxacillin disc diffusion, oxacillin agar screening plates, and the cefoxitin disc diffusion methods. Longanathan A et al. in this issue , report an evaluation of various phenotypic methods with genotypic screening for the detection of MRSA . They suggest that in routine disc diffusion tests, oxacillin can be replaced by cefoxitin for the detection of MRSA and that if PCR is too costly, many laboratories can routinely resort to the combination of simple phenotypic methods, such as cefoxitin disc diffusion and oxacillin MIC, for the detection of MRSA.
Clinicians may have to balance the test techniques available, given the seriousness of the problems of the patients at hand as well as the resources available at their disposal. Efforts to prevent
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