This paper deals with the British dystopian novel Never Let Me Go by Kazuo Ishiguro, in which human clones are forced to donate their organs in an alternate reality set in 1990s England. Through the characters of the novel, various manifestations of suffering are examined from the viewpoint of existentialism. The whole concept of donation might be understood as a metaphorical expression for human life, as well as the omnipresent consciousness of its finitude. Ishiguro has prepared the ground for disturbing discussion where two ostensibly different groups of people – clones, whose only purpose is to donate their vital organs, and “normal people” as the recipients – suddenly appear to be indistinguishable in terms of mortality and the general experience of human existence. This paper focuses on the concept of existential anguish in the context of the novel’s story. Using an unobtrusive science fiction narrative, Never Let Me Go encourages readers to contemplate the essence, meaning and purpose of human life, and it quietly points to topics that are usually treated as highly sensitive: the inevitability of death and apparent absurdity of human existence.